2021
DOI: 10.3390/cells10020342
|View full text |Cite
|
Sign up to set email alerts
|

Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer

Abstract: Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to cells with an abnormal number of chromosomes, also known as an aneuploid state. Induced aneuploidy is detrimental during development and in primary cells but aneuploidy is also a hallmark of cancer cells. It is therefore believed that premalignant cells need to overcome aneuploidy-imposed stresses to become tumorigenic. Over the past decade, some aneuploidy-tolerating pathways have been identified through small-sc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(2 citation statements)
references
References 124 publications
(178 reference statements)
0
2
0
Order By: Relevance
“…Gene mutations have implications in the occurrence and advancement of cancer., including its malignant transformation [32,33]. In the current investigation, we gured out the abnormal expression of CDCA7 in various tumors and used cBioPortal tools to investigate its mutation characteristics.…”
Section: Discussionmentioning
confidence: 99%
“…Gene mutations have implications in the occurrence and advancement of cancer., including its malignant transformation [32,33]. In the current investigation, we gured out the abnormal expression of CDCA7 in various tumors and used cBioPortal tools to investigate its mutation characteristics.…”
Section: Discussionmentioning
confidence: 99%
“…It is a very important genetic marker and the variation in sequence from normal can indicate the presence of a carcinogenic process. [57][58][59] As a powerful technique in molecular genetics, DNA sequencing provides analysis of genes at the nucleotide level. The main focus of DNA sequencing is to determine the sequence of small regions of interest (∼1 kilobase) using a PCR product as a template.…”
Section: Dna Mutationmentioning
confidence: 99%