Amide proton transfer imaging can predict tumor grade in rectal cancer

Comparison and combination of amide proton transfer magnetic resonance imaging and the apparent diffusion coefficient in differentiating the grades of prostate cancer

“…Takayama et al (14) reported that, as PCa differentiation decreased, the APT values first increased and then decreased, and the mean APT values in PCa with a Gleason score of 7 were higher than those for the other Gleason score groups. The APT values in Takayama et al's study did not show a significant rank correlation with the Gleason score groups, which differed from those studies involving APT imaging of other malignant tumors (19,(21)(22)(23). This trend was not found in our study because there were only 2 GGs, but our results still showed significant differences between GG ≤2 and GG ≥3.…”

Comparison and combination of amide proton transfer magnetic resonance imaging and the apparent diffusion coefficient in differentiating the grades of prostate cancer

“…Takayama et al (14) reported that, as PCa differentiation decreased, the APT values first increased and then decreased, and the mean APT values in PCa with a Gleason score of 7 were higher than those for the other Gleason score groups. The APT values in Takayama et al's study did not show a significant rank correlation with the Gleason score groups, which differed from those studies involving APT imaging of other malignant tumors (19,(21)(22)(23). This trend was not found in our study because there were only 2 GGs, but our results still showed significant differences between GG ≤2 and GG ≥3.…”

Breast Amide Proton Transfer Imaging at 3 T : Diagnostic Performance and Association With Pathologic Characteristics

“…As an independent prognostic factor, breast cancer with higher histologic grades have poorer differentiation and worse prognosis than those with lower histologic grades. 37 In this study, IBC-NST lesions with higher histologic grade showed significantly higher APTw contrast than that of lesions with lower histologic grade, accordant with previous tumor studies, 5,19,20,33,38,39 suggesting the ability of APTw signal in noninvasively evaluating the histologic malignancy grade. Similarly, IBC-NST patients in T2 stage and T3 stage No significant difference in APTw signals was shown between positive and negative lymph node metastasis groups in primary breast cancer patients, consistent with published results.…”

CEST‐MRI for body oncologic imaging: are we there yet?

“…The mean MTR asym was higher in benign lesions, contradicting previous studies in breast cancer, 39,53 as well as APT studies in other cancer types. 17,55,56 However, high-grade cancers had a higher MTR asym compared with low-grade cancers, which agrees with previous studies.…”

“…In addition, APT was also statistically significantly ( p < 0.001) different in tumors with low versus high Ki‐67 status (MTR asym = 1.7882 ± 0.11386 versus 2.3975 ± 0.41586). The observed correlation with Ki‐67 is analogous to the observations in breast 53 and brain tumors, 17 but contradictory to the study by Nishie et al in rectal cancer 55 . The authors speculate that the discrepancies in these observations may stem from differences in tumor types, sample size, and the APT implementation.…”

Comparison and combination of amide proton transfer magnetic resonance imaging and the apparent diffusion coefficient in differentiating the grades of prostate cancer

“…Takayama et al (14) reported that, as PCa differentiation decreased, the APT values first increased and then decreased, and the mean APT values in PCa with a Gleason score of 7 were higher than those for the other Gleason score groups. The APT values in Takayama et al's study did not show a significant rank correlation with the Gleason score groups, which differed from those studies involving APT imaging of other malignant tumors (19,(21)(22)(23). This trend was not found in our study because there were only 2 GGs, but our results still showed significant differences between GG ≤2 and GG ≥3.…”

Breast Amide Proton Transfer Imaging at 3 T : Diagnostic Performance and Association With Pathologic Characteristics

“…As an independent prognostic factor, breast cancer with higher histologic grades have poorer differentiation and worse prognosis than those with lower histologic grades. 37 In this study, IBC-NST lesions with higher histologic grade showed significantly higher APTw contrast than that of lesions with lower histologic grade, accordant with previous tumor studies, 5,19,20,33,38,39 suggesting the ability of APTw signal in noninvasively evaluating the histologic malignancy grade. Similarly, IBC-NST patients in T2 stage and T3 stage No significant difference in APTw signals was shown between positive and negative lymph node metastasis groups in primary breast cancer patients, consistent with published results.…”

CEST‐MRI for body oncologic imaging: are we there yet?

“…The mean MTR asym was higher in benign lesions, contradicting previous studies in breast cancer, 39,53 as well as APT studies in other cancer types. 17,55,56 However, high-grade cancers had a higher MTR asym compared with low-grade cancers, which agrees with previous studies.…”

“…In addition, APT was also statistically significantly ( p < 0.001) different in tumors with low versus high Ki‐67 status (MTR asym = 1.7882 ± 0.11386 versus 2.3975 ± 0.41586). The observed correlation with Ki‐67 is analogous to the observations in breast 53 and brain tumors, 17 but contradictory to the study by Nishie et al in rectal cancer 55 . The authors speculate that the discrepancies in these observations may stem from differences in tumor types, sample size, and the APT implementation.…”

Comparison and combination of amide proton transfer magnetic resonance imaging and the apparent diffusion coefficient in differentiating the grades of prostate cancer

“…Takayama et al (14) reported that, as PCa differentiation decreased, the APT values first increased and then decreased, and the mean APT values in PCa with a Gleason score of 7 were higher than those for the other Gleason score groups. The APT values in Takayama et al's study did not show a significant rank correlation with the Gleason score groups, which differed from those studies involving APT imaging of other malignant tumors (19,(21)(22)(23). This trend was not found in our study because there were only 2 GGs, but our results still showed significant differences between GG ≤2 and GG ≥3.…”

Breast Amide Proton Transfer Imaging at 3 T : Diagnostic Performance and Association With Pathologic Characteristics

“…As an independent prognostic factor, breast cancer with higher histologic grades have poorer differentiation and worse prognosis than those with lower histologic grades. 37 In this study, IBC-NST lesions with higher histologic grade showed significantly higher APTw contrast than that of lesions with lower histologic grade, accordant with previous tumor studies, 5,19,20,33,38,39 suggesting the ability of APTw signal in noninvasively evaluating the histologic malignancy grade. Similarly, IBC-NST patients in T2 stage and T3 stage No significant difference in APTw signals was shown between positive and negative lymph node metastasis groups in primary breast cancer patients, consistent with published results.…”

CEST‐MRI for body oncologic imaging: are we there yet?

“…The mean MTR asym was higher in benign lesions, contradicting previous studies in breast cancer, 39,53 as well as APT studies in other cancer types. 17,55,56 However, high-grade cancers had a higher MTR asym compared with low-grade cancers, which agrees with previous studies.…”

“…In addition, APT was also statistically significantly ( p < 0.001) different in tumors with low versus high Ki‐67 status (MTR asym = 1.7882 ± 0.11386 versus 2.3975 ± 0.41586). The observed correlation with Ki‐67 is analogous to the observations in breast 53 and brain tumors, 17 but contradictory to the study by Nishie et al in rectal cancer 55 . The authors speculate that the discrepancies in these observations may stem from differences in tumor types, sample size, and the APT implementation.…”