2016
DOI: 10.18632/aging.101022 View full text |Buy / Rent full text
|
|

Abstract: Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and directional deregulating events concerning DNA methylation controllers, which may underpin the age-related epigenetic changes. In this context, 5mC-hydroxylases (TET enzymes) are new potential play… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
0
28
1

Publication Types

Select...

Relationship

0
0

Authors

Journals