Bactericidal/permeability-increasing protein (BPI) in sepsis correlates with the severity of sepsis and the outcome

Abstract

The BPI and BPI/neutrophil ratios may serve as adjunctive tools to illustrate the severity of sepsis. However, their predictive power for sepsis-related death was not comparable to that of SAPS II scores and IL-8.

Noninfectious Pulmonary Complications after Stem Cell Transplantation and Induction of an Innate Immune Response

“…BPI also blocks the endotoxic effects of LPS and promotes phagocytosis of BPI-coated bacteria [21][22][23]. Previous reports also showed that very high plasma levels of BPI correlate with increased mortality [24,25], and that plasma concentrations of BPI are significantly higher among community-acquired pneumonia patients than among healthy control subjects [26]. These findings and our present results suggest that the mechanism of developing NIPC is associated with pulmonary infection by Gram-negative pathogens.…”

Noninfectious Pulmonary Complications after Stem Cell Transplantation and Induction of an Innate Immune Response

“…BPI also blocks the endotoxic effects of LPS and promotes phagocytosis of BPI-coated bacteria [21][22][23]. Previous reports also showed that very high plasma levels of BPI correlate with increased mortality [24,25], and that plasma concentrations of BPI are significantly higher among community-acquired pneumonia patients than among healthy control subjects [26]. These findings and our present results suggest that the mechanism of developing NIPC is associated with pulmonary infection by Gram-negative pathogens.…”

Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis

“…BPI is an antimicrobial protein selective for Gram-negative bacteria. The level of BPI correlated with mortality, with higher levels in patients not surviving 90 days after inclusion, confirming previous results by Rintala and collegues [9] as well as by Calvano et al [8] . The results suggest that BPI alone does not protect from death.…”

Bactericidal/permeability-increasing protein in lacrimal gland and in tears of healthy subjects

“…The first stage of BPI secreted by the basal layers of the ductal epithelium of the lacrimal gland may be modified The results of the present study showed that the mean concentration of BPI in tears of healthy subjects was 27.8± 29.5 μg/l (mean±SD). This concentration markedly exceeds the level found in normal plasma (7.3 μg/l) [21,25]. The mean concentration of BPI of the tear fluid showed a very high SD similarly as observed earlier in the mean content of lysozyme [27] and GIIAPLA 2 [26].…”

Noninfectious Pulmonary Complications after Stem Cell Transplantation and Induction of an Innate Immune Response

“…BPI also blocks the endotoxic effects of LPS and promotes phagocytosis of BPI-coated bacteria [21][22][23]. Previous reports also showed that very high plasma levels of BPI correlate with increased mortality [24,25], and that plasma concentrations of BPI are significantly higher among community-acquired pneumonia patients than among healthy control subjects [26]. These findings and our present results suggest that the mechanism of developing NIPC is associated with pulmonary infection by Gram-negative pathogens.…”

Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis

“…BPI is an antimicrobial protein selective for Gram-negative bacteria. The level of BPI correlated with mortality, with higher levels in patients not surviving 90 days after inclusion, confirming previous results by Rintala and collegues [9] as well as by Calvano et al [8] . The results suggest that BPI alone does not protect from death.…”

Bactericidal/permeability-increasing protein in lacrimal gland and in tears of healthy subjects

“…The first stage of BPI secreted by the basal layers of the ductal epithelium of the lacrimal gland may be modified The results of the present study showed that the mean concentration of BPI in tears of healthy subjects was 27.8± 29.5 μg/l (mean±SD). This concentration markedly exceeds the level found in normal plasma (7.3 μg/l) [21,25]. The mean concentration of BPI of the tear fluid showed a very high SD similarly as observed earlier in the mean content of lysozyme [27] and GIIAPLA 2 [26].…”

Noninfectious Pulmonary Complications after Stem Cell Transplantation and Induction of an Innate Immune Response

“…BPI also blocks the endotoxic effects of LPS and promotes phagocytosis of BPI-coated bacteria [21][22][23]. Previous reports also showed that very high plasma levels of BPI correlate with increased mortality [24,25], and that plasma concentrations of BPI are significantly higher among community-acquired pneumonia patients than among healthy control subjects [26]. These findings and our present results suggest that the mechanism of developing NIPC is associated with pulmonary infection by Gram-negative pathogens.…”

Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis

“…BPI is an antimicrobial protein selective for Gram-negative bacteria. The level of BPI correlated with mortality, with higher levels in patients not surviving 90 days after inclusion, confirming previous results by Rintala and collegues [9] as well as by Calvano et al [8] . The results suggest that BPI alone does not protect from death.…”

Bactericidal/permeability-increasing protein in lacrimal gland and in tears of healthy subjects

“…The first stage of BPI secreted by the basal layers of the ductal epithelium of the lacrimal gland may be modified The results of the present study showed that the mean concentration of BPI in tears of healthy subjects was 27.8± 29.5 μg/l (mean±SD). This concentration markedly exceeds the level found in normal plasma (7.3 μg/l) [21,25]. The mean concentration of BPI of the tear fluid showed a very high SD similarly as observed earlier in the mean content of lysozyme [27] and GIIAPLA 2 [26].…”