2015
DOI: 10.18632/aging.100818 View full text |Buy / Rent full text
|
|

Abstract: Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes with it in cytosolic inclusions. It was suggested HDAC4 interacts with MAP1S in a yeast two-hybrid screening. Here, we found that MAP1S interacts with HDAC4 via a HDAC4-binding domain (HBD). HDAC4 destabilizes MAP1S, supp… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
0
27
0

Publication Types

Select...

Relationship

0
0

Authors

Journals