Abstract:We have defined the histone acetylation pattern of the endogenous murine ␤-globin domain, which contains the erythroidspecific ␤-globin genes. The ␤-globin locus control region (LCR) and transcriptionally active promoters were enriched in acetylated histones in fetal liver relative to fetal brain, whereas the inactive promoters were hypoacetylated. In contrast, the LCR and both active and inactive promoters were hyperacetylated in yolk sac. Hypersensitive site two of the LCR was also hyperacetylated in murine … Show more
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