2000
DOI: 10.1073/pnas.97.26.14295 View full text |Buy / Rent full text
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Abstract: The mutation rates of cancer cells to drug and multidrug resistance are paradoxically high, i.e., 10 ؊3 to 10 ؊6 , compared with those altering phenotypes of recessive genes in normal diploid cells of about 10 ؊12 . Here the hypothesis was investigated that these mutations are due to chromosome reassortments that are catalyzed by aneuploidy. Aneuploidy, an abnormal number of chromosomes, is the most common genetic abnormality of cancer cells and is known to change phenotypes (e.g., Down's syndrome). Moreover, … Show more

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