1996
DOI: 10.2220/biomedres.17.293 View full text |Buy / Rent full text
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Abstract: The role played by endogenous bradykinin (BK) on the hypothalamo-pituitary-adrenal (HPA) axis was investigated in the rat. Normal and ether-stressed (2 min ether-vapor inhalation) or cold-stressed (20 min at 4°C) animals were given a bolus subcutaneous injection of 20 nmol of D-Arg,[Hyp3, D-P1167]-BK, an antagonist of B2 subtype of BK receptors (BKA); the blood concentrations of ACTH, aldosterone (ALDO) and corticosterone (B) were measured by specific RIA, 1, 2 or 4h after the injection. BKA did not evoke sign… Show more

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