Abstract:This paper describes our recent investigations on the construction of synthetic cells. By following a bottom-up synthetic biology approach, we aim at constructing minimal synthetic cells based on the encapsulation of DNA, RNA and proteins within liposomes. We will firstly comment on the physics of solute entrapment inside liposomes, giving emphasis on a remarkable self-concentration effect discovered by us (Luisi et al. 2010, Souza et al. 2011, 2012). Next we will show how it is possible to exploit this phenom… Show more
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