2016
DOI: 10.1177/0962280216664759 View full text |Buy / Rent full text
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Abstract: Multi-arm clinical trials assessing multiple experimental treatments against a shared control group can offer efficiency advantages over independent trials through assessing an increased number of hypotheses. Published opinion is divided on the requirement for multiple testing adjustment to control the familywise type-I error rate (FWER). The probability of a false positive error in multiarm trials compared to equivalent independent trials is affected by the correlation between comparisons due to sharing contr… Show more

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