2017
DOI: 10.18632/aging.101307 View full text |Buy / Rent full text
Has erratum 2018-9-28Comment 2018-1-8Has correction 2018-9-28
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Abstract: The stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD+-dependent manner and is implicated in cellular senescence and aging. Here we reveal a novel function of SIRT4 in mitochondrial morphology/quality control and regulation of mitophagy. We report that moderate overexpression of SIRT4, but not its enzymatically inactive mutant H161Y, sensitized cells to mitochondrial stress. CCCP-triggered dissipation of the mitochondrial membrane potential resulted in increased mitocho… Show more

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