Stimulatory Effects of Monoacetyldiglycerides on Hematopoiesis

PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2

“…This compound can be synthesized from glycerol, palmitic acid, and linoleic acid. We have previously confirmed that our synthetic PLAG is chemically identical to the naturally isolated form [24,25]. We recently confirmed its pharmacological activity against hepatic injury and its ability to augment the effect of pegfilgrastim on gemcitabine-induced neutropenia and oral mucositis.…”

PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2

“…This compound can be synthesized from glycerol, palmitic acid, and linoleic acid. We have previously confirmed that our synthetic PLAG is chemically identical to the naturally isolated form [24,25]. We recently confirmed its pharmacological activity against hepatic injury and its ability to augment the effect of pegfilgrastim on gemcitabine-induced neutropenia and oral mucositis.…”

1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol (PLAG) reduces hepatic injury in concanavalin A‐treated mice

“…We chemically synthesized PLAG from glycerol, palmitic acid, and linoleic acid and confirmed that the synthetic PLAG was chemically identical to its naturally isolated form . Recently, evidence has indicated that PLAG from deer antlers possesses pharmacological activities, such as anti‐tumor, immunomodulatory, anti‐allergic, anti‐metastatic, and hematopoiesis effects in in vitro and in vivo experiments. However, the effect of PLAG on liver injury, including leukocyte infiltration caused by Con A, has not been carefully examined.…”

“…1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol (PLAG) exists in natural resources such as seed oils, the bovine udder, milk fat, and the antler of Sika deer . We chemically synthesized PLAG from glycerol, palmitic acid, and linoleic acid and confirmed that the synthetic PLAG was chemically identical to its naturally isolated form . Recently, evidence has indicated that PLAG from deer antlers possesses pharmacological activities, such as anti‐tumor, immunomodulatory, anti‐allergic, anti‐metastatic, and hematopoiesis effects in in vitro and in vivo experiments.…”

EC-18, a Synthetic Monoacetyldiacylglyceride, Inhibits Hematogenous Metastasis of KIGB-5 Biliary Cancer Cell in Hamster Model

“…We previously reported that the water extracts from deer antler, Cervus nippon , had a stimulating effects on hematopoiesis in vitro and in vivo (4, 5), and we subsequently demonstrated that monoacetyldiglyceride (EC-18) was the component with the most potent stimulatory activity on the bone marrow stem cells, bone marrow stromal cells and immune cells.…”

PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2

“…This compound can be synthesized from glycerol, palmitic acid, and linoleic acid. We have previously confirmed that our synthetic PLAG is chemically identical to the naturally isolated form [24,25]. We recently confirmed its pharmacological activity against hepatic injury and its ability to augment the effect of pegfilgrastim on gemcitabine-induced neutropenia and oral mucositis.…”

1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol (PLAG) reduces hepatic injury in concanavalin A‐treated mice

“…We chemically synthesized PLAG from glycerol, palmitic acid, and linoleic acid and confirmed that the synthetic PLAG was chemically identical to its naturally isolated form . Recently, evidence has indicated that PLAG from deer antlers possesses pharmacological activities, such as anti‐tumor, immunomodulatory, anti‐allergic, anti‐metastatic, and hematopoiesis effects in in vitro and in vivo experiments. However, the effect of PLAG on liver injury, including leukocyte infiltration caused by Con A, has not been carefully examined.…”

“…1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol (PLAG) exists in natural resources such as seed oils, the bovine udder, milk fat, and the antler of Sika deer . We chemically synthesized PLAG from glycerol, palmitic acid, and linoleic acid and confirmed that the synthetic PLAG was chemically identical to its naturally isolated form . Recently, evidence has indicated that PLAG from deer antlers possesses pharmacological activities, such as anti‐tumor, immunomodulatory, anti‐allergic, anti‐metastatic, and hematopoiesis effects in in vitro and in vivo experiments.…”

EC-18, a Synthetic Monoacetyldiacylglyceride, Inhibits Hematogenous Metastasis of KIGB-5 Biliary Cancer Cell in Hamster Model

“…We previously reported that the water extracts from deer antler, Cervus nippon , had a stimulating effects on hematopoiesis in vitro and in vivo (4, 5), and we subsequently demonstrated that monoacetyldiglyceride (EC-18) was the component with the most potent stimulatory activity on the bone marrow stem cells, bone marrow stromal cells and immune cells.…”

PLAG enhances macrophage mobility for efferocytosis of apoptotic neutrophils via membrane redistribution of P2Y2

“…This compound can be synthesized from glycerol, palmitic acid, and linoleic acid. We have previously confirmed that our synthetic PLAG is chemically identical to the naturally isolated form [24,25]. We recently confirmed its pharmacological activity against hepatic injury and its ability to augment the effect of pegfilgrastim on gemcitabine-induced neutropenia and oral mucositis.…”

1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol (PLAG) reduces hepatic injury in concanavalin A‐treated mice

“…We chemically synthesized PLAG from glycerol, palmitic acid, and linoleic acid and confirmed that the synthetic PLAG was chemically identical to its naturally isolated form . Recently, evidence has indicated that PLAG from deer antlers possesses pharmacological activities, such as anti‐tumor, immunomodulatory, anti‐allergic, anti‐metastatic, and hematopoiesis effects in in vitro and in vivo experiments. However, the effect of PLAG on liver injury, including leukocyte infiltration caused by Con A, has not been carefully examined.…”

“…1‐palmitoyl‐2‐linoleoyl‐3‐acetyl‐rac‐glycerol (PLAG) exists in natural resources such as seed oils, the bovine udder, milk fat, and the antler of Sika deer . We chemically synthesized PLAG from glycerol, palmitic acid, and linoleic acid and confirmed that the synthetic PLAG was chemically identical to its naturally isolated form . Recently, evidence has indicated that PLAG from deer antlers possesses pharmacological activities, such as anti‐tumor, immunomodulatory, anti‐allergic, anti‐metastatic, and hematopoiesis effects in in vitro and in vivo experiments.…”

EC-18, a Synthetic Monoacetyldiacylglyceride, Inhibits Hematogenous Metastasis of KIGB-5 Biliary Cancer Cell in Hamster Model

“…We previously reported that the water extracts from deer antler, Cervus nippon , had a stimulating effects on hematopoiesis in vitro and in vivo (4, 5), and we subsequently demonstrated that monoacetyldiglyceride (EC-18) was the component with the most potent stimulatory activity on the bone marrow stem cells, bone marrow stromal cells and immune cells.…”