Abstract:The earliest cytological abnormalities to be recognized in pernicious anaemia were, of course, those of the blood. Apart from the various changes seen in the mature red cells, circulating nucleated precursors showed sufficiently striking alterations for Ehrlich to give them the separate name of megaloblast (Ehrlich, 1880 The enlargement of the nuclei of the buccal cells can best be studied in smears of saliva, and one of us (M. M. B.) began to measure these cells in order to determine whether the changes are s… Show more
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