2014
DOI: 10.18632/aging.100706 View full text |Buy / Rent full text
|
|

Abstract: Aging is associated with severe thermogenic impairment, which contributes to obesity and diabetes in aging. We previously reported that ablation of the ghrelin receptor, growth hormone secretagogue receptor (GHS-R), attenuates age-associated obesity and insulin resistance. Ghrelin and obestatin are derived from the same preproghrelin gene. Here we showed that in brown adipocytes, ghrelin decreases the expression of thermogenic regulator but obestatin increases it, thus showing the opposite effects. We also fou… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
4
67
0

Publication Types

Select...

Relationship

0
0

Authors

Journals