A Quantitative Comparison of Simultaneous BOLD fMRI and NIRS Recordings during Functional Brain Activation

Strangman, Gary E.; Culver, Joseph P.; Thompson, John H.; Boas, David A.

doi:10.1006/nimg.2002.1227

Cited by 1,114 publications

(701 citation statements)

References 67 publications

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“…HHb concentration increases or decreases after stimulus onset. Similar discrepancies have been described further as partial volume effect (Boas et al, 2001, Strangman et al, 2002b, Huppert et al, 2006, Xu et al, 2007. Partial volume effect is the effect wherein insufficient image resolution leads to a mixing of different tissue types.…”

Section: Partial Volume Effectsupporting

confidence: 55%

Task complexity relates to activation of cortical motor areas during uni- and bimanual performance: A functional NIRS study

Holper

Biallas²,

Wolf³

2009

NeuroImage

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Task complexity relates to activation of cortical motor areas during uni-and bimanual performance: a functional NIRS study Holper, L; Biallas, M; Wolf, M Holper, L; Biallas, M; Wolf, M (2009 AbstractHand motor tasks are frequently used to assess impaired motor function in neurology and neurorehabilitation. Assessments can be varied by means of hand laterality, i.e. unimanual or bimanual performance, as well as by means of task complexity, i.e. different degrees ranging from simple to complex sequence tasks. The resulting functional activation in human primary motor cortex (M1) has been studied intensively by traditional neuroimaging methods.Previous studies using functional near-infrared spectroscopy (fNIRS) investigated simple hand motor tasks. However, it is unknown whether fNIRS can also detect changes in response to increasing task complexity. Our hypothesis was to show that fNIRS could detect activation changes in relation to task complexity in uni-and bimanual tasks.Sixteen healthy right-handed subjects performed five finger-tapping tasks: unimanual left and right, simple and complex tasks as well as bimanual complex tasks. We found significant We report for the first time that fNIRS detects oxygenation changes in relation to task complexity during finger-tapping. The study aims to contribute to the establishment of fNIRS as a neuroimaging method to assess hand motor function in clinical settings where traditional neuroimaging methods cannot be applied.

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Section: Partial Volume Effectsupporting

confidence: 55%

Task complexity relates to activation of cortical motor areas during uni- and bimanual performance: A functional NIRS study

Holper

Biallas²,

Wolf³

2009

NeuroImage

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“…The instrument is described in more detail elsewhere Strangman et al, 2002). The 18 laser diodes (nine emitting light at 690 nm, and nine at 830 nm) were frequencyencoded by steps of approximately 200 Hz between 4.0 kHz and 7.4 kHz, so their signals could be acquired simultaneously by the 16 parallel detectors.…”

Section: Doi Instrumentmentioning

confidence: 99%

Coupling between somatosensory evoked potentials and hemodynamic response in the rat

Franceschini

Nissilä

et al. 2008

NeuroImage

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We studied the relationship between somatosensory evoked potentials (SEP) recorded with scalp electroencephalography (EEG) and hemoglobin responses recorded non-invasively with diffuse optical imaging (DOI) during parametrically varied electrical forepaw stimulation in rats. Using these macroscopic techniques we verified that the hemodynamic response is not linearly coupled to the somatosensory evoked potentials, and that a power or threshold law best describes the coupling between SEP and the hemoglobin response, in agreement with the results of most invasive studies. We decompose the SEP response in three components (P1, N1, and P2) to determine which best predicts the hemoglobin response. We found that N1 and P2 predict the hemoglobin response significantly better than P1 and the input stimuli (S). Previous electrophysiology studies reported in the literature show that P1 originates in layer IV directly from thalamocortical afferents, while N1 and P2 originate in layers I and II and reflect the majority of local cortico-cortical interactions. Our results suggest that the evoked hemoglobin response is driven by the cortical synaptic activity and not by direct thalamic input. The N1 and P2 components, and not P1, need to be considered to correctly interpret neurovascular coupling.

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“…Several recent studies compared the hemodynamic response to brain activation as measured by functional near-infrared spectroscopy (fNIRS) with another imaging method, such as functional magnetic resonance imaging (fMRI) (Hoge et al, 2005;Kennan et al, 2002;Kleinschmidt et al, 1996;Mehagnoul-Schipper et al, 2002;Obrig et al, 2000b;Seiyama et al, 2004;Siegel et al, 2003;Strangman et al, 2002;Toronov et al, 2001aToronov et al, ,b, 2003Wenzel et al, 2000) or positron emission tomography (PET) . While optical measurements are poorer in spatial resolution and depth penetration than fMRI, they are biochemical specific and, consequently, provide information about changes in oxy-, deoxy-, and total hemoglobin (Hb) with a high temporal resolution (Hoshi, 2003;Villringer and Chance, 1997).…”

Section: Introductionmentioning

confidence: 99%

Investigating the post-stimulus undershoot of the BOLD signal—a simultaneous fMRI and fNIRS study

et al. 2006

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Measuring the hemodynamic response with functional magnetic resonance imaging (fMRI) together with functional near-infrared spectroscopy (fNIRS) may overcome limitations of single-method approaches. Accordingly, we measured the event-related hemodynamic response with both imaging methods simultaneously in young subjects during visual stimulation. An intertrial interval of 60 s was chosen to include the prolonged post-stimulus undershoot of the blood oxygenation level dependent (BOLD) signal. During visual stimulation, the BOLD signal, oxy-, and total hemoglobin (Hb) increased, whereas deoxy-Hb decreased. The post-stimulus period was characterized by an undershoot of the BOLD signal, oxy-Hb, and an overshoot of deoxy-Hb. Total Hb as measured by fNIRS returned to baseline immediately after the end of stimulation. Results suggest that the post-stimulus events as measured by fNIRS are dominated by a prolonged high-level oxygen consumption in the microvasculature. The contribution of a delayed return of blood volume to the BOLD post-stimulus undershoot in post-capillary veins as suggested by the Balloon and Windkessel models remains ambiguous. Temporal changes in the BOLD signal were highly correlated with deoxy-Hb, with lower correlation values for oxy-and total Hb. Furthermore, data show that fNIRS covers the outer 1 cm of the brain cortex. These results were confirmed by simultaneous fMRI/fNIRS measurements during rest. In conclusion, multimodal imaging approaches may contribute to the understanding of neurovascular coupling. D

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A Quantitative Comparison of Simultaneous BOLD fMRI and NIRS Recordings during Functional Brain Activation

Cited by 1,114 publications

References 67 publications

Task complexity relates to activation of cortical motor areas during uni- and bimanual performance: A functional NIRS study

Task complexity relates to activation of cortical motor areas during uni- and bimanual performance: A functional NIRS study

Coupling between somatosensory evoked potentials and hemodynamic response in the rat

Investigating the post-stimulus undershoot of the BOLD signal—a simultaneous fMRI and fNIRS study

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