A Review of Psychoactive Substance Use and Abuse in Schizophrenia

Schneier, Franklin R.; Siris, Samuel G.

doi:10.1097/00005053-198711000-00001

Cited by 313 publications

(191 citation statements)

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“…Patients with schizophrenia show alarmingly high rates of substance use disorders (20-65%) [308][309][310][311][312][313], as well as a considerably greater risk of developing a drug addiction disorder than individuals in the general population [314]. As reviewed in detail elsewhere [315], dually diagnosed schizophrenia patients typically present with more severe symptoms [308,309,[316][317][318][319], exhibit increased suicidal ideation [320,321], require more frequent hospitalizations [310,322], and experience more frequent relapses than patients without co-occurring substance abuse [323][324][325].…”

Section: Homers Addiction and Schizophrenia Co-morbiditymentioning

confidence: 99%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

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Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state.

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Section: Homers Addiction and Schizophrenia Co-morbiditymentioning

confidence: 99%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

View full text Add to dashboard Cite

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“…Schneier and Siris (1987) and Mueser et al (1990) provided methodologically sophisticated and exhaustive reviews of studies that compared the use of illicit drugs and alcohol by schizophrenic patients with normal and psychiatric control groups. Both reviews concluded that schizophrenic patients choose substances for abuse in a nonrandom manner.…”

mentioning

confidence: 99%

A longitudinal study of drug and alcohol use by psychosis-prone and impulsive-nonconforming individuals.

Kwapil¹

1996

Journal of Abnormal Psychology

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The rates of substance use and abuse are higher among psychotic patients and antisocial individuals than in the general population. In a 10-year longitudinal study, psychosis-prone individuals identified by the Perceptual Aberration (L. J. Chapman, J. P. Chapman, M. L. Raulin, 1976) and Magical Ideation (Per-Mag) scales (M. Eckblad & L. J. Chapman, 1983), and individuals with antisocial traits, identified by the Impulsive Nonconformity (Noncon) scale (L. J. Chapman et al., 1984), exceeded a control group on rates of substance use disorders. As hypothesized, the Per-Mag group demonstrated preferential patterns of substance use similar to those reported for schizophrenic patients. Participants who scored deviantly on both the Per-Mag and Noncon scales were at especially heightened risk for substance use disorders. Psychosis proneness at the initial screening predicted substance abuse at the follow-up evaluation, but substance abuse at the initial interview did not predict later clinical psychosis or psychoticlike experiences.

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“…28 Some stimulant drugs produce improved functioning and reduced symptoms in some patients and interestingly some schizophrenic patients may preferentially abuse stimulant. 29 They are taken as they counteract distressing negative symptoms or neuroleptic-induced akathisia. 30,31 Cocaine has been reported to reduce negative symptoms while cannabis increased positive symptoms of schizophrenia.…”

Section: The Vulnerability Model Hypothesizes That Drug Abusementioning

confidence: 99%