Abdominal Visceral Fat is Associated with a <i>Bcl</i>I Restriction Fragment Length Polymorphism at the Glucocorticoid Receptor Gene Locus

Buemann, B; Vohl, Marie‐Claude; Chagnon, Monique; Chagnon, Yvon C.; Gagnon, Jacques; Pérusse, Louis; Dionne, F. T.; Després, Jean‐Pierre; Tremblay, Angelo; Nadeau, André; Bouchard, Claude

doi:10.1002/j.1550-8528.1997.tb00292.x

Cited by 177 publications

(135 citation statements)

References 25 publications

(27 reference statements)

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…7 The present study, based on a larger QFS sample, shows that the association of the 4.5 kb allele with a higher AVF area is true for any level of body FM since AVF data were adjusted for the latter. The association of the GRL variant with AVF is therefore independent of total FM and it explains why the heterozygotes who had the highest BMI and FM did not present the highest accumulation of AVF.…”

Section: Discussionmentioning

confidence: 51%

“…Gene interactions and obesity phenotypes O Ukkola et al influencing steroid metabolism has been postulated 7,28 and could also contribute to the observed associations. In addition to the effects of the GRL locus, the data of the present study show that several interactions between the GRL, LPL and ADR genes are associated with variations in regional fat distribution phenotypes.…”

Section: Gene Interactions and Obesity Phenotypesmentioning

confidence: 99%

“…However, earlier studies have failed to consistently demonstrate any major effect of these genes on regional fat distribution. 6,7 One possible explanation is that the contribution of these genes is primarily through genegene interactions, which are likely to be ubiquitous in the genetic determinants of obesity. 8 This is a topic that has received little attention thus far.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study

et al. 2001

View full text Add to dashboard Cite

OBJECTIVE:To investigate whether interactions between glucocorticoid receptor (GRL), lipoprotein lipase (LPL) and adrenergic receptor (ADR) gene markers contribute to individual differences in indicators of adiposity and abdominal obesity, including visceral fat level. DESIGN AND SUBJECTS: Cross-sectional study; 742 individuals from the phase 2 of the Québec Family Study cohort. MEASUREMENTS: Total body fat assessed by hydrodensitometry and the sum of six skinfolds. Abdominal fat areas measured by computed tomography and adjusted for age, sex and total fat mass in all analyses. GRL Bcl I, a2A-ADR Dra I and b2-ADR Ban I markers were typed by Southern blot, and other markers by polymerase chain reaction technique. RESULTS: It is confirmed that the 4.5 kb allele of the GRL BclI polymorphism is associated with a higher amount of abdominal visceral fat (AVF) depot (P for trend < 0.001) independent of the level of total body fat. Furthermore, the a2-ADR Dra I variant is associated with lower cross-sectional areas of abdominal total (P ¼ 0.003) and subcutaneous (P ¼ 0.012) adipose tissue. Genegene interactions between GRL and a2-ADR genes affecting overall adiposity (P ¼ 0.016) as well as between GRL and b2-ADR genes (P ¼ 0.049) having influence on total abdominal fat levels were observed. When the three genes were considered together in the same analysis, significant interactions having influence on overall adiposity (P ¼ 0.017), abdominal total (P ¼ 0.032) and visceral fat (P ¼ 0.002) were observed. About 1 -2% of the total variation in total fatness and abdominal fat was explained by these gene -gene interactions. CONCLUSION: There is an association between the GRL BclI polymorphism and increased AVF levels independent of the level of total body fat. The a2-ADR DraI variant is associated with a lower cross-sectional area of abdominal total fat. Numerous interactions between GRL and ADR markers on overall adiposity and total abdominal fat as well as between GRL, LPL and ADR genes on overall adiposity, abdominal total and visceral fat suggest that the genetic architecture of body fat content and adipose tissue distribution is complex although some genes, like GRL, may have ubiquitous effects.

show abstract

Section: Discussionmentioning

confidence: 51%

Section: Gene Interactions and Obesity Phenotypesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study

et al. 2001

View full text Add to dashboard Cite

show abstract

“…In these subjects, the polymorphism was found to account for 41 and 35%, in men and women, respectively, of the total variance in AVF area. 51 In a general population of non-Cushingoid middle-aged Swedish men, the 4.5-kb fragment was associated with elevated BMI, WHR, and abdominal sagittal diameter. 52 In a randomly selected subgroup of the Newcastle Heart Project, a polymorphism of the NR3C1 resulting in an asparagine-to-serine substitution at codon 363, previously described, tested, and proven to lack any functional effects in vitro, 97 was found to be associated with WHR in Caucasian men.…”

Section: Leptin Receptor Gene (Lepr)mentioning

confidence: 95%

“…97 In the QFS cohort, two studies have reported that a biallelic (4.5-and 2.3-kb alleles) polymorphism is associated with a higher abdominal visceral fat (AVF) area in both men and women, independently of total body fat mass. 19,51 However, the association with AVF was seen only in subjects of the lower tertile of the percent body fat level. In these subjects, the polymorphism was found to account for 41 and 35%, in men and women, respectively, of the total variance in AVF area.…”

Section: Leptin Receptor Gene (Lepr)mentioning

confidence: 96%

Association studies of genetic polymorphisms in central obesity: a critical review

Rosmond

2003

Int J Obes

View full text Add to dashboard Cite

During the past decade, mutations affecting liability to central obesity have been discovered at a phenomenal rate, and despite few consistently replicated findings, a number of intriguing results have emerged in the literature. Association studies have been proposed to identify the genetic determinants of complex traits such as central obesity. The advantages of the association method include its relative robustness to genetic heterogeneity and the ability to detect much smaller effect sizes than is detectable using feasible sample sizes in linkage studies. However, the current literature linking central obesity to genetic variants is teeming with reports of associations that either cannot be replicated or for which corroboration by linkage has been impossible to find. Explanations for this lack of reproducibility are well rehearsed, and typically include poor study design, incorrect assumptions about the underlying genetic architecture, and simple overinterpretation of data. These limitations create concern about the validity of association studies and cause problems in establishing robust criteria for undertaking association studies. In this article, the current status of the literature of association studies for genetic dissection of central obesity is critically reviewed.

show abstract

Genetics of abdominal visceral fat levels

1999

Self Cite

View full text Add to dashboard Cite

Abdominal Visceral Fat is Associated with a BclI Restriction Fragment Length Polymorphism at the Glucocorticoid Receptor Gene Locus

Cited by 177 publications

References 25 publications

Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study

Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study

Association studies of genetic polymorphisms in central obesity: a critical review

Genetics of abdominal visceral fat levels

Contact Info

Product

Resources

About