Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis

Toulis, Konstantinos; Goulis, Dimitrios G.; Farmakiotis, Dimitrios; Georgopoulos, Neoklis A.; Katsikis, Ilias; Tarlatzis, Basil C.; Papadimas, Ioannis; Panidis, Dimitrios

doi:10.1093/humupd/dmp006

Cited by 214 publications

(156 citation statements)

References 67 publications

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“…The direct effect of adiponectin in human ovarian function remains unclear; in animal models, adiponectin has been observed to influence follicular remodelling and folliculogenesis and to modulate sex steroid secretion via activation of its own receptor (adiponectin R1 and R2) and via modulation of the insulin/IGF system (Ledoux et al 2006, Chabrolle et al 2007, Campos et al 2008, Pierre et al 2009). Women with PCOS appear to have lower levels of adiponectin than non-PCO controls, and obese anovulatory women with PCOS have lower levels still, although this is not a consistent finding in the literature (Carmina et al 2005, Toulis et al 2009). It has been proposed that hypoadiponectinaemia in patients with PCOS or women with central obesity may contribute to worsening insulin resistance and its negative effect upon normal folliculogenesis (Escobar-Morreale et al 2006).…”

Section: Other Adipokinesmentioning

confidence: 88%

The adverse effects of obesity on conception and implantation

Brewer¹,

Balen²

2010

Reproduction

397

268

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Whilst many multiparous women are obese (body mass index O30 kg/m 2 ), obesity has been associated with impaired fecundity; however, the mechanism which links obesity to reduced fertility remains to be fully elucidated. Obese women, particularly those with central obesity, are less likely to conceive per cycle. Obese women suffer perturbations to the hypothalamic-pituitary-ovarian axis, menstrual cycle disturbance and are up to three times more likely to suffer oligo-/anovulation. A fine hormonal balance regulates follicular development and oocyte maturation, and it has been observed that obesity can alter the hormonal milieu. Leptin, a hormone produced by adipocytes, is elevated in obese women, and raised leptin has been associated with impaired fecundity. Obesity impairs ovulation but has also been observed to detrimentally affect endometrial development and implantation. The expression of polycystic ovary syndrome (PCOS) is regulated, in part, by weight, and so obese women with PCOS often have a more severe phenotype and experience more subfertility. Obesity also impairs the response of women to assisted conception treatments. Weight loss through lifestyle modification or bariatric surgery has been demonstrated to restore menstrual cyclicity and ovulation and improve the likelihood of conception. In this article, we will discuss the effect of obesity upon key reproductive mechanisms and its relation to fertility treatments.

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Section: Other Adipokinesmentioning

confidence: 88%

The adverse effects of obesity on conception and implantation

Brewer¹,

Balen²

2010

Reproduction

397

268

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show abstract

“…A meta-analysis revealed that serum APN levels are lower in women with PCOS compared with BMI-matched healthy controls (Toulis et al 2009). In addition, it was found that obese PCOS patients have lower APN levels than non-obese PCOS patients.…”

Section: Adiponectinmentioning

confidence: 99%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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“…This syndrome presents defects in primary cellular control mechanisms that result in the expression of chronic anovulation, hyperandrogenism, and polycystic ovaries [2,3].…”

Section: Introductionmentioning

confidence: 99%

Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation

Resende

Vireque

Santana

et al. 2012

J Assist Reprod Genet

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Purpose To detect expression of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) in oocytes, and their receptor type 2 receptor for BMPs (BMPR2) in cumulus cells in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF), and determine if BMPR2, BMP15, and GDF9 expression correlate with hyperandrogenism in FF of PCOS patients. Methods Prospective case-control study. Eighteen MIIoocytes and their respective cumulus cells were obtained from 18 patients with PCOS, and 48 MII-oocytes and cumulus cells (CCs) from 35 controls, both subjected to controlled ovarian hyperstimulation (COH), and follicular fluid (FF) was collected from small (10-14 mm) and large (>18 mm) follicles. RNeasy Micro Kit (Qiagen ® ) was used for RNA extraction and gene expression was quantified in each oocyte individually and in microdissected cumulus cells from cumulus-oocyte complexes retrieved from preovulatory follicles using qRT-PCR. Chemiluminescence and RIA assays were used for hormone assays. Results BMP15 and GDF9 expression per oocyte was higher among women with PCOS than the control group. A positive correlation was found between BMPR2 transcripts and hyperandrogenism in FF of PCOS patients. Progesterone values in FF were lower in the PCOS group. Conclusion We inferred that BMP15 and GDF9 transcript levels increase in mature PCOS oocytes after COH, and might inhibit the progesterone secretion by follicular cells in PCOS follicles, preventing premature luteinization in cumulus cells. BMPR2 expression in PCOS cumulus cells might be regulated by androgens.

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Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis

Cited by 214 publications

References 67 publications

The adverse effects of obesity on conception and implantation

The adverse effects of obesity on conception and implantation

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation

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