An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial

Zilaee, Marzie; Hosseini, Seyed Ahmad; Jafarirad, Sima; Abolnezhadian, Farhad; Cheraghian, Bahman; Namjoyan, Foroogh; Ghadiri, Ataollah

doi:10.1186/s12931-019-0998-x

Cited by 39 publications

(37 citation statements)

References 20 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of our clinical trial showed that saffron supplementation (100 mg of dried saffron stigma in capsules) for 8 weeks in mild and moderate allergic asthmatic patients improved the lung function by increasing the forced expiratory volume in 1 second (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC ratio, and forced expiratory flow (FEF) 25-75 and decreased some inflammatory factors (anti-HSP 70 and hs-CRP) in comparison to placebo [8]. In this trial the clinical symptoms of patients (including frequency of the shortness of breath during day-and nighttime, use of salbutamol spray, waking up due to asthma symptoms, and activity limitation) improved after saffron supplementation [9].…”

Section: Saffron and Asthmamentioning

confidence: 78%

Nutritional Recommendations in Asthmatic Patients

Zilaee¹,

Hosseini²

2019

Asthma - Biological Evidences

Self Cite

View full text Add to dashboard Cite

Asthma is a heterogeneous disease, and airway inflammation has an important role in its pathogenesis. Some nutritional factors can influence the process of asthma. It is reported that saffron has anti-inflammatory, antioxidant, and muscle relaxant effects, and some animal and human studies showed that saffron and its active components (safranal and crocin) improved the asthma biomarkers and clinical symptoms. Some other nutritional factors also affect asthma; for example, magnesium can relax the muscles and thus has bronchodilatory effects. Curcumin is the major active component of turmeric which has a potent antioxidant, anti-inflammatory, and anti-allergic effects. Because some researchers suggested that intestinal microbial flora has an important role in allergy, probiotics can be a complementary supplement for asthmatic patients. Generally nutritional factors could be advised for asthmatic patients with the goal of reducing the needs for chemical drugs.

show abstract

Section: Saffron and Asthmamentioning

confidence: 78%

Nutritional Recommendations in Asthmatic Patients

Zilaee¹,

Hosseini²

2019

Asthma - Biological Evidences

Self Cite

View full text Add to dashboard Cite

show abstract

“…In traditional medicine, Crocus sativus L, which is more commonly known as saffron, has been used as a treatment for heart disease, depression, stress, and sleep disorders [ 5 ]. C sativus L possesses antioxidant [ 6 ] and anti-inflammatory properties [ 7 ]. Its active components—safranal and crocin—have demonstrated beneficial anti-inflammatory and antioxidant effects [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies [ 6 , 8 , 9 ] have reported the effects of C sativus L on asthmatic patients. Zilaee et al [ 6 ] studied, in a randomized clinical trial, the effects of C sativus L supplements on clinical symptoms, Asthma Severity Score, blood pressure, and lipid profiles of patients with mild or moderate persistent allergic asthma. Although these studies showed aggregate effects, it was not possible to predict rare and serious effects for individuals.…”

Section: Introductionmentioning

confidence: 99%

Neural Network–Based Clinical Prediction System for Identifying the Clinical Effects of Saffron (Crocus sativus L) Supplement Therapy on Allergic Asthma: Model Evaluation Study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background Asthma is commonly associated with chronic airway inflammation and is the underlying cause of over a million deaths each year. Crocus sativus L, commonly known as saffron, when used in the form of traditional medicines, has demonstrated anti-inflammatory effects which may be beneficial to individuals with asthma. Objective The objective of this study was to develop a clinical prediction system using an artificial neural network to detect the effects of C sativus L supplements on patients with allergic asthma. Methods A genetic algorithm–modified neural network predictor system was developed to detect the level of effectiveness of C sativus L using features extracted from the clinical, immunologic, hematologic, and demographic information of patients with asthma. The study included data from men (n=40) and women (n=40) individuals with mild or moderate allergic asthma from 18 to 65 years of age. The aim of the model was to estimate and predict the level of effect of C sativus L supplements on each asthma risk factor and to predict the level of alleviation in patients with asthma. A genetic algorithm was used to extract input features for the clinical prediction system to improve its predictive performance. Moreover, an optimization model was developed for the artificial neural network component that classifies the patients with asthma using C sativus L supplement therapy. Results The best overall performance of the clinical prediction system was an accuracy greater than 99% for training and testing data. The genetic algorithm–modified neural network predicted the level of effect with high accuracy for anti–heat shock protein (anti-HSP), high sensitivity C-reactive protein (hs-CRP), forced expiratory volume in the first second of expiration (FEV1), forced vital capacity (FVC), the ratio of FEV1/FVC, and forced expiratory flow (FEF25%-75%) for testing data (anti-HSP: 96.5%; hs-CRP: 98.9%; FEV1: 98.1%; FVC: 97.5%; FEV1/FVC ratio: 97%; and FEF25%-75%: 96.7%, respectively). Conclusions The clinical prediction system developed in this study was effective in predicting the effect of C sativus L supplements on patients with allergic asthma. This clinical prediction system may help clinicians to identify early on which clinical factors in asthma will improve over the course of treatment and, in doing so, help clinicians to develop effective treatment plans for patients with asthma.

show abstract

“…Moderate-to-severe asthma involves activation of interferon (IFN)-γ-producing Th1/Th17 cells 8 , monocytes 9 , neutrophils, airway inflammation 7,10 , elevated lung lavage and serum IgE levels 11,12,13 , and systemic and airway accumulation of inflammatory cytokines 7,8,12 14,15 . Clinical symptoms of asthma include wheezing, shortness of breath, cough 8 , tightness in chest 16 , sputum production, and limited ability to expire air 17 .…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol

Kent¹,

Obi²,

Jeyaraman³

et al. 2020

Preprint

View full text Add to dashboard Cite

Asthma is the most common chronic disease in children. It is characterized by difficulty in breathing and chronic airway inflammation associated with narrowing of the airways, and airway hyperresponsiveness. If left untreated, asthma can lead to respiratory distress and even death. A number of medications are available and prescribed to manage asthma. Yet despite that, only half of the asthmatic patients are able to control their condition. Extracellular vesicles (EVs) play an important role in transporting contents such as nucleic acids, proteins, and lipids to other cells. While EVs have been extensively studied as biomarkers of various pathological states, evidence indicates that they can play protective and therapeutic roles in mitigating diseases such as cancer, cardiovascular disease and asthma. Here we propose to conduct a systematic review that provides a detailed analysis of the therapeutic effect of EVs in mitigating the primary (inflammation, airway hyperresponsiveness) and secondary outcomes (airway remodelling, molecular indices of cellular signalling, and inflammatory mediators in serum) associated with asthma in preclinical studies.

show abstract

An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial

Cited by 39 publications

References 20 publications

Nutritional Recommendations in Asthmatic Patients

Nutritional Recommendations in Asthmatic Patients

Neural Network–Based Clinical Prediction System for Identifying the Clinical Effects of Saffron (Crocus sativus L) Supplement Therapy on Allergic Asthma: Model Evaluation Study

The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol

Contact Info

Product

Resources

About