Antioxidants: Scientific Literature Landscape Analysis

Yeung, Andy Wai Kan; Tzvetkov, Nikolay; El-Tawil, Osama S.; Bungău, Simona; Abdel-Daim, Mohamed M.; Atanasov, Atanas G.

doi:10.1155/2019/8278454

Cited by 148 publications

(102 citation statements)

References 26 publications

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“…The current literature analysis on lignan publications revealed the large publication shares from Asian countries, which were consistent with related bodies of literature such as antioxidants and curcumin (Yeung et al, 2019b;Yeung et al, 2019c). Examples of some highly cited original research papers recently published by Asian teams in the 2010s, without international collaborations, are discussed here.…”

Section: Discussionsupporting

confidence: 84%

Lignans: Quantitative Analysis of the Research Literature

et al. 2020

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The current study provides a comprehensive overview and analysis of the lignan literature. Data for the current study were extracted from the electronic Web of Science Core Collection database via the search string TOPIC = ("lignan*") and processed by the VOSviewer software. The search yielded 10,742 publications. The ratio of original articles to reviews was 14.6:1. Over 80% of the analyzed papers have been published since the year 2000 and nearly 50% since the year 2010. Many of the publications were focused on pharmacology, chemistry, and plant sciences. The United States and Asian countries, such as China, Japan, South Korea, and India, were the most productive producers of lignan publications. Among the 5 most productive institutions was the University of Helsinki in Finland, the country that ranked 9 th . Nineteen journals collectively published 3,607 lignan publications and were considered as core journals. Their impact factor did not correlate with the proportion of uncited papers. Highly cited publications usually mentioned phytoestrogen, isoflavone, daidzein, enterodiol, enterolactone, equol, genistein, and isoflavonoid. Cancer (e.g., breast cancer), cardiovascular disease, and antioxidation were the major themes. Clinical trials were estimated to contribute to 0.2-1.1% of the analyzed body of literature, so more of them should be conducted in the future to substantiate the beneficial effects and optimal dose of lignan intake in humans. Moreover, researchers can refer to these findings for future research directions and collaborations.

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Section: Discussionsupporting

confidence: 84%

Lignans: Quantitative Analysis of the Research Literature

et al. 2020

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“…Nitric oxide (NO) is considered to actively regulate several vital physiological functions including germination, growth, enzyme activity, responses to stresses and stress signaling [15,16]. Exogenous application of NO prevents the salinity-induced photosynthetic inhibition by neutralizing the accumulated ROS [17][18][19]. However, the excess can be toxic due to its radical nature.…”

Section: Introductionmentioning

confidence: 99%

Exogenous Nitric Oxide Mitigates Nickel-Induced Oxidative Damage in Eggplant by Upregulating Antioxidants, Osmolyte Metabolism, and Glyoxalase Systems

Soliman

Alhaithloul

Hakeem

et al. 2019

Plants

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Nitric oxide (NO) at optimal levels is considered beneficial to plant functioning. The present study was carried out to investigate the role of exogenously applied NO (100 and 150 µM sodium nitropurusside, SNP) in amelioration of nickel (Ni)-mediated oxidative effects in eggplant. Ni stress declined growth and biomass production, relative water content (RWC), and chlorophyll pigment synthesis, thereby affecting the photosynthetic efficiency. Exogenously applied SNP proved beneficial in mitigating the Ni-mediated growth restrictions. NO-treated seedlings exhibited improved photosynthesis, stomatal conductance, and chlorophyll content with the effect of being apparent at lower concentration (100 µM SNP). SNP upregulated the antioxidant system mitigating the oxidative damage on membranes due to Ni stress. The activity of superoxide dismutase, catalase, glutathione S-transferase, ascorbate peroxidase, and glutathione reductase was upregulated due to SNP which also increased the ascorbate and reduced glutathione content. SNP-supplied seedlings also showed higher proline and glycine betaine accumulation, thereby improving RWC and antioxidant system. Glyoxalase I activity was induced due to SNP application declining the accumulation of methylglyoxal. NO-mediated mitigation of Ni toxicity was confirmed using NO scavenger (PTIO,4,5,, which reversed the influence of SNP almost entirely on the parameters studied. Uptake of nitrogen (N), potassium (K), and calcium (Ca) was increased due to SNP application and Ni was reduced significantly. Therefore, this study revealed the efficiency of exogenous SNP in enhancing Ni stress tolerance through upregulating antioxidant and glyoxalase systems.

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“…Antioxidants are substances capable of retarding or inhibiting the oxidation processes of various atmospheric oxygen systems or reactive chemical species derived therefrom. Due to oxidative stress, the cell is damaged and the human body begins to age and face a number of serious diseases such as: diabetes, cancer, cardiovascular diseases [13][14][15][16][17][18]. The increased interest in the replacement of synthetic antioxidants from food with the natural ones has supported the search of plant sources and the choice of raw materials for new antioxidants identification.…”

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confidence: 99%

Statistical Analysis of the Relationship Between Antioxidant Activity and the Structure of Flavonoid Compounds

Glevitzky¹,

Dumitrel²,

Glevitzky³

et al. 2019

Rev. Chim.

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Using different methods of statistics, this paper aims to highlight the potential link between the antioxidant activity of flavonoids and the corresponding molecular descriptors. By calculating the descriptors (van der Waals surface (A), molar volume (V), partition coefficient (LogP), refractivity (R), polarizability (a), forming heat (Hformation), hydration energy (Ehidr), the dipole moment (mt)), together with antioxidant activities (RSA) calculated or taken from the literature, number of phenolic -OH groups and the presence (2) or absence (1) of C2=C3 double bond) for 29 flavonoid compounds and by intercorrelation between the studied parameters, the link between the number of phenolic groups grafted to the basic structure of flavonoids and their antioxidant activity was confirmed. Simultaneously, by using the chi-squared test and the intercorrelations matrix, a satisfactorily correlation coefficient (r2=0.5678; r=0.7536) between the structure of the flavonoids and their activity was obtained, fact that confirms the correlation of the antioxidant activity with the number of -OH phenolic groups.

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Antioxidants: Scientific Literature Landscape Analysis

Cited by 148 publications

References 26 publications

Lignans: Quantitative Analysis of the Research Literature

Lignans: Quantitative Analysis of the Research Literature

Exogenous Nitric Oxide Mitigates Nickel-Induced Oxidative Damage in Eggplant by Upregulating Antioxidants, Osmolyte Metabolism, and Glyoxalase Systems

Statistical Analysis of the Relationship Between Antioxidant Activity and the Structure of Flavonoid Compounds

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