Argus II retinal prosthesis system: An update

Rachitskaya, Aleksandra; Yuan, Alex

doi:10.3109/13816810.2015.1130152

Cited by 24 publications

(27 citation statements)

References 41 publications

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“…The first retinal prosthesis to enter clinical trials was a 5000-electrode microphotodiode chip (Artificial Silicon Retina [ASR], subretinal approach; Optobionics, Glen Ellyn, Ill, 2000, see [5–7]), and it produced successful results. At present, two devices have been approved as commercial products with clinical trials: the subretinal visual implants Alpha IMS (Retina Implant AG, Reutlingen, Germany, see [8,9]), which induce excitation of the internal plexiform layer, and the Argus II implants (Second Sight, Sylmar, CA, see [10–12]), which induce excitation of the ganglion cell axons with an epiretinal implant, requiring simpler and less invasive surgery.…”

Section: Introductionmentioning

confidence: 99%

Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis

et al. 2016

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Retinal prosthesis technologies require that the visual system downstream of the retinal circuitry be capable of transmitting and elaborating visual signals. We studied the capability of plastic remodeling in late blind subjects implanted with the Argus II Retinal Prosthesis with psychophysics and functional MRI (fMRI). After surgery, six out of seven retinitis pigmentosa (RP) blind subjects were able to detect high-contrast stimuli using the prosthetic implant. However, direction discrimination to contrast modulated stimuli remained at chance level in all of them. No subject showed any improvement of contrast sensitivity in either eye when not using the Argus II. Before the implant, the Blood Oxygenation Level Dependent (BOLD) activity in V1 and the lateral geniculate nucleus (LGN) was very weak or absent. Surprisingly, after prolonged use of Argus II, BOLD responses to visual input were enhanced. This is, to our knowledge, the first study tracking the neural changes of visual areas in patients after retinal implant, revealing a capacity to respond to restored visual input even after years of deprivation.

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Section: Introductionmentioning

confidence: 99%

Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis

et al. 2016

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“…The Argus II retinal prosthesis system is marked for "European Conformity" (Conformité Européene -CE) and has been available in the European Economic Area since 2011. In addition, the system is accepted as a humanitarian device with authorization by the Food and Drug Administration of the United States [6]. The Argus II RPS has been implanted in patients from various countries who have totally lost their central vision [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The Argus II project is a well-known RPS that provides electrical stimulation of the retina to induce visual perception in blind individuals [6]. The block diagram of the system is illustrated in Figure 1, which appears courtesy of Prof Dr Mark S Humayun and Second Sight Medical Products.…”

Section: Introductionmentioning

confidence: 99%

“…These pulses stimulate the retina's healthy cells while avoiding the damaged photoreceptors. This could enhance the transmission of visual information along the optic nerve to the brain in order to create the perception of patterns of light [6]. The Argus II retinal prosthesis system is marked for "European Conformity" (Conformité Européene -CE) and has been available in the European Economic Area since 2011.…”

Section: Introductionmentioning

confidence: 99%

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Circularly polarized implantable antenna characterization for retinal prosthesis systems

Kaka¹,

Toycan²,

Walker³

2018

Turk J Elec Eng & Comp Sci

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Abstract:We describe a miniaturized antenna design for retinal prosthesis applications that enhances data transfer between the implant and external camera. The circularly polarized and conformal 2.4-2.48 GHz microstrip patch antenna was simulated inside the vitreous humor and is intended for biomedical applications. Modified Hilbert and serpentine geometries were used for the proposed implant antenna design. Capacitive radiator loading offered miniaturized dimensions of 5.8 × 6.5 × 2 mm 3 (width × height × thickness mm 3 ) . A truncated design enhanced the intrinsic circular polarization characteristics to > 3 dB axial ratio. Polydimethylsiloxane substrate and superstrate materials were used to achieve an S 11 value below -15 dB across the frequency range with biocompatible characteristics. The simulated peak gains for left-hand circular polarization and right-hand circular polarization at 2.45 GHz were -50 dBi and -60 dBi, respectively. These relatively small values were due to the high conductivity of the vitreous humor ( σ = 1.53 S/m), which imposed significant losses. Overall, the proposed antenna had an omnidirectional radiation pattern and + 8.45 dBm input to meet the specific absorption rate regulation limit.

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“…Regarding vision assistance, there is a prosthetic system for the most severe cases with none or almost no light perception. The Argus II device provides a sort of artificial vision by sidestepping the photoreceptors and supplying the electric stimuli directly to the residual retina (Rachitskaya and Yuan 2016). This retinal prosthesis is composed of a set of glasses, an external video processing unit, and an on-globe surface implant coil that connects through cables to the last component, an electrode in the retina.…”

Section: Prosthetic Systemsmentioning

confidence: 99%

Therapeutic approaches and development of genomic diagnostic tools for Usher syndrome

García¹

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Gracias también a todo mi grupillo de Philly que tan rápida y cálidamente me recibieron en su cuadrilla. En especial a Berta y Álvaro, por allanarme tanto el camino; y a Alba y Vicky, que desde el primer minuto os desvivisteis por que aprovechara al máximo mi estancia. Many thanks to Dr. Hakonarson and all the CAG members for allowing me the opportunity to learn from such a proficient and nice team during those six months. No me olvido tampoco del resto de amigos que, sólo con interesarse por mi trabajo o darme apoyo moral, también me ayudado durante estos años. Y, por supuesto, gracias a mi familia. A mis abuelos, porque sé que muchas de mis capacidades las he heredado de ellos, y porque sé la enorme ilusión que les habría hecho ser partícipes de este momento. En especial, a mi abuelo Jesús, quien sembró mi interés por la investigación y a quien le hubiese entusiasmado saber que finalmente desarrollé su profesión platónica. A Adrián, mil gracias (y me quedo corta). Es una gran suerte poder compartir las ilusiones e inquietudes del gremio con mi compañero de vida y de vocación. Gracias por sacarme de tantos apuros, porque literalmente sin ti me habría estancado. Gracias por escucharme cuando he necesitado desahogarme, por animarme y aconsejarme, y por disfrutar con mis éxitos. Gracias, en suma, por ser mi cómplice en todo. Gracias, de manera muy profunda, a mis padres, a quienes dedico esta tesis. Por innumerables motivos que, a fin de cuentas y de forma desvirtuada, se reducen a una esencia: por apoyarme siempre en todo, por las oportunidades que me habéis dado, por educarme como lo habéis hecho, y por vuestro desmedido cariño. Porque si he llegado hasta aquí, ha sido por vosotros, y porque si soy quien soy, es por vosotros. Gracias papá, gracias mamá, por ser como sois. Finalmente, mi más sincera gratitud a todos los pacientes y sus familiares que han participado en los estudios. Al fin y al cabo, todo esto es por vosotros. Gracias por vuestra confianza. Quiero creer que nuestro empeño, si no el de otros, acabará traduciéndose en una solución.

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Argus II retinal prosthesis system: An update

Cited by 24 publications

References 41 publications

Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis

Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis

Circularly polarized implantable antenna characterization for retinal prosthesis systems

Therapeutic approaches and development of genomic diagnostic tools for Usher syndrome

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