Associations of social networks with cancer mortality: A meta-analysis

Pinquart, Martin; Duberstein, Paul R.

doi:10.1016/j.critrevonc.2009.06.003

Cited by 353 publications

(321 citation statements)

References 123 publications

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“…Moreover, chronic psychosocial stress increases cancer mortality across a diverse array of cancer types (e.g., breast, lung, head and neck, hepatobiliary, lymphoid, and hematopoietic cancers) 105,106 . A possible behavioral explanation implies the fact that psychological stress exerts detrimental effects on sleep architecture integrity and increases fatigue.…”

Section: Stress As a Modulator Of Immune Response In Depression And Cmentioning

confidence: 99%

Depression in cancer: The many biobehavioral pathways driving tumor progression

Bortolato

Hyphantis

Valpione

et al. 2017

Cancer Treatment Reviews

219

172

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Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote:(1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitary-adrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioural pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed.

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Section: Stress As a Modulator Of Immune Response In Depression And Cmentioning

confidence: 99%

Depression in cancer: The many biobehavioral pathways driving tumor progression

Bortolato

Hyphantis

Valpione

et al. 2017

Cancer Treatment Reviews

219

172

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“…Similar to our findings, Manzoli et al (Manzoli et al 2007) found that separated/divorced cancer patients had the worst survival of any marital status group. Conversely, a number of other study have found that never-married patients have worse survival than both widowed and separated/ divorced patients (Pinquart & Duberstein 2010;Kravdal & Syse 2011;Kravdal 2013;Kravdal 2001), at least for some categories of patients. Early data from Norway (women diagnosed with cancer between 1996 and 1990 (Kvikstad et al 1995)) showed that divorced women had an overall increased hazard ratio of 1.17 (95% CI = 1.07-1.27) for cancers including lung cancer compared to married women, whereas widows had no increased risk.…”

Section: Discussionmentioning

confidence: 96%

“…Previous studies on marriage and survival focused on the social support benefits that married couples have compared with never married or divorced/separated. For example, Pinquart (Pinquart & Duberstein 2010) posited that social networks, which would include marriage, would have effects on: biological pathways (neuroendocrine or neuro-immune pathways), health behaviors, access to health care systems and assistance with navigating its complexities, the likelihood of receiving vigorous and aggressive, active cancer treatment, and psychological consequences. All of these could have direct and/or indirect effects on survival.…”

Section: Discussionmentioning

confidence: 99%

“…Recent and growing literature suggests that psychological factors and the presence or absence of social support may be an important factor influencing the course of cancer (Ikeda et al 2013;Pinquart & Duberstein 2010;Cassileth et al 1988;Rendall et al 2011); this has been shown to be especially strong for breast cancer (Falagas et al 2007;Nausheen et al 2009). There have been mixed results in the literature regarding the specific association of lung cancer survival and marital status.…”

Section: Introductionmentioning

confidence: 99%

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Marital status and its effect on lung cancer survival

Wang¹,

Koru‐Sengul²,

Tannenbaum³

et al. 2013

PsycEXTRA Dataset

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Purpose: The purpose of this study was to determine if marital status, including specific types of single status categories, is associated with length of survival in lung cancer patients.Methods: Data from the 1996-2007 Florida Cancer Data System were linked with Agency for Health Care Administration data and U.S. Census data. Patients with both small cell and non-small cell lung cancer were identified (n = 161,228). Marital status was characterized by married, widowed, separated/divorced, and never married. We compared median survival time and 1, 3, and 5-year post diagnosis survival rates. Results: Overall, 54.6% were married, 19.1% were widowed, 13.5% were separated/divorced, and 12.7% had never married. Median survival in months was longest for married (9.9) and widowed (7.7) patients, and shortest for never married (4.9) and separated/divorced (4.1) patients. Five-year survival rates were 14.2% for married, 10.7% for widowed, 8.9% for separated/divorced, and 8.4% for never married. In univariate Cox regression, marital status was a significant predictor of better survival for married (HR = 0.70; p < 0.001) and widowed (HR = 0.81; p < 0.001) patients compared with never married patients, but worse for separated/divorced patients (HR = 1.03; p = 0.003). Multivariate models demonstrated sustained survival benefits for married (HR = 0.86; p < 0.001) and widowed (HR = 0.88; p < 0.001) patients, and detriments for separated/divorced patients (HR = 1.05; p < 0.001) after adjusting for extensive confounders including demographics; tumor stage, grade, and morphology; comorbidities; treatment; and smoking status.Conclusions: Our study demonstrated that married or widowed lung cancer patients have better survival compared to patients who were never married or separated/divorced. Research to understand the mechanism of this effect, and how the beneficial effect can be extended to those who have never married or have had the marital relationship severed through divorce or separation is needed.

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“…An individual's social environment can have an impact on their quality of life; social support can have a positive effect both on mortality (Pinquart & Duberstein, 2010) and psychological health (Godding et al, 1995;Griffiths et al, 2009). Some authors have suggested that group-based interventions may produce added social benefits, through providing social interaction with, and emotional support from, other cancer survivors who have a similar understanding of the problems and experiences associated with the cancer journey.…”

Section: Individual Versus Group Basedmentioning

confidence: 99%

Physical Activity and Cancer

Bk¹,

Ih²,

Rohde³

2013

Encyclopedia of Behavioral Medicine

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It is widely accepted that physical activity is important for physical functioning and well-being, and as such the promotion of active lifestyles is becoming increasingly significant in public health policy both in the UK and worldwide. Sedentary lifestyles have been associated with increased risk of obesity and preventable disease including diabetes, coronary heart disease and some cancers. With regards cancer specifically, this chapter will provide a brief overview on current opinions on the link between physical activity and cancer prevention.The published evidence focuses both on primary and secondary prevention. More recent evidence has investigated the use of physical activity in secondary prevention for those who have been diagnosed with cancer and proposed a link between physical activity, morbidity and mortality in those with cancer. The evidence-base for secondary prevention is more limited. Nevertheless, studies to date have indicated that physical activity can improve both physical functioning and psychological outcomes in cancer survivors, and significantly improve quality of life.The exact nature of those interventions which confer the most positive effects is less well-established, and there is a current lack of consensus on the most appropriate type, intensity and duration of activity for people with cancer. It has not yet been wellestablished as to which stage of the treatment programme physical activity should be encouraged (during or following treatment) or the most appropriate length of time during which structured physical activity interventions should be delivered to achieve beneficial results.These factors will be discussed in this chapter, and barriers to engaging in physical activity for those with a diagnosis of cancer will be considered. The chapter will conclude with a summary of key findings and the potential for further research.

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Associations of social networks with cancer mortality: A meta-analysis

Cited by 353 publications

References 123 publications

Depression in cancer: The many biobehavioral pathways driving tumor progression

Depression in cancer: The many biobehavioral pathways driving tumor progression

Marital status and its effect on lung cancer survival

Physical Activity and Cancer

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