Associations of subclinical autistic-like traits with brain structural variation using diffusion tensor imaging and voxel-based morphometry

Schröder, Yvonne; Hohmann, Daniela Michelle; Meller, Tina; Evermann, Ulrika; Pfarr, Julia‐Katharina; Jansen, Andreas; Kamp‐Becker, Inge; Grezellschak, Sarah; Nenadić, Igor

doi:10.1192/j.eurpsy.2021.15

Cited by 3 publications

(4 citation statements)

References 63 publications

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“…To the best of our knowledge, this is the first study that has exploited Granger causality analysis to investigate the brain organization connected to autistic features in a resting-state electroencephalographic study. Although there is abundant evidence of abnormal brain connectivity in clinical forms of autism, there are limited studies investigating whether such abnormalities are also traceable in the general population with high autistic traits [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, although autistic traits are distributed to varying degrees in the general population, it remains unclear whether the peculiarities in brain organization found in ASD patients are also present to a lesser degree in non-clinical individuals with high autistic traits. The first studies conducted analyzing this subclinical population showed that higher levels of autism features are related to decreased white matter integrity in tracts associated with visual processing and increased cortical volume in areas related to working memory [ 30 ]. Other studies showed that having higher autistic traits was correlated with white matter alteration in the inferior fronto-occipital fasciculus [ 31 ] and a negative correlation was found between individual autistic traits and the efficiency of brain networks in an EEG study [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

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The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits

et al. 2021

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Altered patterns of brain connectivity have been found in autism spectrum disorder (ASD) and associated with specific symptoms and behavioral features. Growing evidence suggests that the autistic peculiarities are not confined to the clinical population but extend along a continuum between healthy and maladaptive conditions. The aim of this study was to investigate whether a differentiated connectivity pattern could also be tracked along the continuum of autistic traits in a non-clinical population. A Granger causality analysis conducted on a resting-state EEG recording showed that connectivity along the posterior-frontal gradient is sensitive to the magnitude of individual autistic traits and mostly conveyed through fast oscillatory activity. Specifically, participants with higher autistic traits were characterized by a prevalence of ascending connections starting from posterior regions ramping the cortical hierarchy. These findings point to the presence of a tendency within the neural mapping of individuals with higher autistic features in conveying proportionally more bottom-up information. This pattern of findings mimics those found in clinical forms of autism, supporting the idea of a neurobiological continuum between autistic traits and ASD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits

et al. 2021

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“…Further, autistic traits are found to be associated with the clinical features of autism and are also suggested to share a common aetiology with these features (Ronald et al, 2006). Additional support for a dimensional approach to autistic traits and autism comes from research finding that alterations in brain structures in typical individuals with a high number of autistic traits resemble alterations previously found in individuals with a clinical diagnosis of autism (Schröder et al, 2021). Therefore, examining the broader autism phenotype provides insight into autism.…”

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confidence: 96%

Autistic Traits are Associated with Less Precise Perceptual Integration of Face Identity

Turbett

Jeffery

Bell

et al. 2021

J Autism Dev Disord

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Face recognition difficulties are common in autism and could be a consequence of perceptual atypicalities that disrupt the ability to integrate current and prior information. We tested this theory by measuring the strength of serial dependence for faces (i.e., how likely is it that current perception of a face is biased towards a previously seen face) across the broader autism phenotype. Though serial dependence was not weaker in individuals with more autistic traits, more autistic traits were associated with greater integration of less similar faces. These results suggest that serial dependence is less specialised, and may not operate optimally, in individuals with more autistic traits and could therefore be a contributing factor to autism-linked face recognition difficulties.

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“…The AQ is proven to have adequate construct validity, convergent validity with related measures and can differentiate people with and without autistic traits [70][71][72]. The AQ score is also associated with differences in structural [73,74] and functional brain patterns [75,76].…”

Section: Psychopathic and Autistic Trait Assessmentmentioning

confidence: 99%

Psychopathic and autistic traits differentially influence the neural mechanisms of social cognition from communication signals

et al. 2022

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Psychopathy is associated with severe deviations in social behavior and cognition. While previous research described such cognitive and neural alterations in the processing of rather specific social information from human expressions, some open questions remain concerning central and differential neurocognitive deficits underlying psychopathic behavior. Here we investigated three rather unexplored factors to explain these deficits, first, by assessing psychopathy subtypes in social cognition, second, by investigating the discrimination of social communication sounds (speech, non-speech) from other non-social sounds, and third, by determining the neural overlap in social cognition impairments with autistic traits, given potential common deficits in the processing of communicative voice signals. The study was exploratory with a focus on how psychopathic and autistic traits differentially influence the function of social cognitive and affective brain networks in response to social voice stimuli. We used a parametric data analysis approach from a sample of 113 participants (47 male, 66 female) with ages ranging between 18 and 40 years (mean 25.59, SD 4.79). Our data revealed four important findings. First, we found a phenotypical overlap between secondary but not primary psychopathy with autistic traits. Second, primary psychopathy showed various neural deficits in neural voice processing nodes (speech, non-speech voices) and in brain systems for social cognition (mirroring, mentalizing, empathy, emotional contagion). Primary psychopathy also showed deficits in the basal ganglia (BG) system that seems specific to the social decoding of communicative voice signals. Third, neural deviations in secondary psychopathy were restricted to social mirroring and mentalizing impairments, but with additional and so far undescribed deficits at the level of auditory sensory processing, potentially concerning deficits in ventral auditory stream mechanisms (auditory object identification). Fourth, high autistic traits also revealed neural deviations in sensory cortices, but rather in the dorsal auditory processing streams (communicative context encoding). Taken together, social cognition of voice signals shows considerable deviations in psychopathy, with differential and newly described deficits in the BG system in primary psychopathy and at the neural level of sensory processing in secondary psychopathy. These deficits seem especially triggered during the social cognition from vocal communication signals.

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Associations of subclinical autistic-like traits with brain structural variation using diffusion tensor imaging and voxel-based morphometry

Cited by 3 publications

References 63 publications

The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits

The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits

Autistic Traits are Associated with Less Precise Perceptual Integration of Face Identity

Psychopathic and autistic traits differentially influence the neural mechanisms of social cognition from communication signals

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