Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives

Popov, Alexander; Krivoshapko, O. N.; Климович, А. А.; Artyukov, A. A.

doi:10.18097/pbmc20166201022

Cited by 8 publications

(5 citation statements)

References 43 publications

(55 reference statements)

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“…When used for therapeutic purposes, RA, LT and DSL have unique features regarding the mechanism of their anti-inflammatory and antioxidant activity; of note, PPC exerted a more pronounced pharmacological effect than its major components, RA, LT and DSL, applied separately. For this reason, the use of combined pharmaceutical agents as PPC (5,26), acting on several different targets in cells, appears to be a promising approach for development of remedies of complementary therapy for preventing and treating multifactorial metabolic diseases. This approach may overcome the abovementioned problems regarding undesirable side effects of potent synthetic PPAR agonists.…”

Section: Discussionmentioning

confidence: 99%

“…These pathological constituents subsequently lead to changes in the structural and functional organization of the membranes and the formation of various pathological processes. Therefore, due to their anti-inflammatory and antioxidant actions, the major components of PPC, RA, LT and its sulfated derivatives, may be utilized for the treatment of MS and T2D (26,27). PPC and its main components showed a high degree of safety and lack of side effects (8,26).…”

Section: Antiinflammatory and Antioxidant Activity Of Ra Lt And Its mentioning

confidence: 99%

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Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action

Styshova

Popov

Artyukov

et al. 2017

Experimental and Therapeutic Medicine

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The present review analyzed the recent experimental studies of the alleviating activity of main constituents of the polyphenol complex from seagrasses of the genus , namely rosmarinic acid, luteolin and its sulfated derivatives, on carbohydrate and lipid metabolism disorders. A number of studies by our group and others, in which various experimental models of diabetes and hyperlipidemia were used, show a therapeutic action of the polyphenol complex and the abovementioned phenolic constituents, when applied separately and in combination. Based on the analysis of the results of these studies, the probable mechanisms of the therapeutic action of these compounds in diabetes and hyperlipidemia were proposed.

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Section: Discussionmentioning

confidence: 99%

Section: Antiinflammatory and Antioxidant Activity Of Ra Lt And Its mentioning

confidence: 99%

Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action

Styshova

Popov

Artyukov

et al. 2017

Experimental and Therapeutic Medicine

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“…SAA has protective effects on acute kidney injury induced by ischemia-reperfusion injury [ 14 ] and can greatly attenuate monocrotaline-induced hypertrophic damage of the myocardium, parenchymal injury, and collagen deposition in the lungs [ 15 ]. RA reportedly has a therapeutic effect on type 2 diabetes and hyperlipidaemia [ 16 ]. Studies have shown that CAA ameliorates cardiac damage in isoproterenol-induced myocardial infarction by maintaining lipid peroxide metabolism because of its free radical scavenging and antioxidant effects [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Distribution Analysis of Salvianolic Acids in Myocardial Ischemic Pig Tissues by Automated Liquid Extraction Surface Analysis Coupled with Tandem Mass Spectrometry

Qiu

Cao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The distribution of active compounds of traditional Chinese medicine Salvia miltiorrhiza Bunge (Chinese name: Danshen) in vivo was determined by establishing a liquid extraction surface analysis coupled with the tandem mass spectrometry (LESA-MS/MS) method. Stability analysis and distribution analysis were designed in the present study using normal animals or a myocardial ischemia model. The model assessment was performed four weeks after surgery, and then three groups were created: a normal-dose group, a model-blank group, and a model-dose group. Meanwhile, Danshen decoction administration began in dose groups and lasted for four weeks. In stability analysis, four salvianolic acids—Danshensu (DSS), caffeic acid (CAA), rosmarinic acid (RA), and salvianolic acid A (SAA)—in kidney tissues from the normal-dose group were detected by LESA-MS/MS under four conditions, and then distribution analysis was conducted in different tissues using the same method. Ejection fraction (EF) and fractional shortening (FS) in animals from two model groups decreased significantly four weeks after surgery (P < 0.01) and were improved after four weeks of Danshen decoction administration (P < 0.01). Results of stability analysis demonstrated that this method was basically stable since there were no significant differences in signal intensities of DSS, CAA, and SAA under four conditions (P > 0.05). Distribution analysis showed the signal intensities of DSS in the liver and kidney and SAA in the heart were higher in the model-dose group than in the normal-dose group (P < 0.05 or P < 0.01). Signal intensities of RA in the liver and kidney, and SAA in the liver were lower in the model-dose group compared with the normal-dose group (P < 0.05 or P < 0.01). In conclusion, Danshen decoction has the effect of improving the ischemic condition in a chronic myocardial ischemia model, and the content of two active compounds increased in the targets. These findings contribute to an understanding of the therapeutic role of Danshen in cardiovascular disease.

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“…Zosteracea species have been found to be widely distributed along different regions, such as temperate North Atlantic, temperate North Pacific, temperate Southern Ocean and Mediterranean [123]. Polyphenol complex from Zosteraceae mainly consists of rosmarinic acid, luteolin, and luteolin disulfate [133]. The polyphenol complex was tested against highly pathogenic strain of the Tick-borne encephalitis (TBE) virus of the Far-Eastern subtype Dalinegorsk (Dal), on porcine embryo kidney (SPEV) cells.…”

Section: Seagrassesmentioning

confidence: 99%

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

et al. 2020

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Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.

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Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives

Cited by 8 publications

References 43 publications

Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action

Main constituents of polyphenol complex from seagrasses of the genus Zostera, their antidiabetic properties and mechanisms of action

Distribution Analysis of Salvianolic Acids in Myocardial Ischemic Pig Tissues by Automated Liquid Extraction Surface Analysis Coupled with Tandem Mass Spectrometry

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

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