Biorefineries for the production of top building block chemicals and their derivatives

Choi, Sangdun; Song, Chul-Hwa; Shin, Jae Ho; Lee, Sang Yup

doi:10.1016/j.ymben.2014.12.007

Cited by 431 publications

(232 citation statements)

References 81 publications

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“…Kraft mills are well suited to provide a wide range of low cost feedstocks to an integrated biorefinery for production of certain bulk chemicals. Choi et al 2015;Taylor et al 2015). For processes that can utilize commodity sugars such as corn dextrose, the use of lignocellulose as a source of sugars may not currently be cost competitive.…”

Section: Bio-advantaged Platform Chemicals From Woodmentioning

confidence: 99%

Integrating a Biorefinery into an Operating Kraft Mill

Johnson¹,

Hart²

2016

BioResources

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Kraft pulp and paper mills have several advantages for serving the emerging biorefinery industry as a source of raw materials. This review examines technologies for producing liquid biofuels, chemicals, and advanced materials from woody feedstocks to generate new sources of revenue. Market pull comes in part from government policies that drive substitution of petroleum-based products with biobased equivalents. Kraft mills have ample networks to supply feedstocks, whether these are forest residues or byproduct side streams. Pulp mills are well suited to expand sufficiently to accommodate production of value added platform chemicals that are in demand because of brand owner sustainability commitments.

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Section: Bio-advantaged Platform Chemicals From Woodmentioning

confidence: 99%

Integrating a Biorefinery into an Operating Kraft Mill

Johnson¹,

Hart²

2016

BioResources

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“…Microbial cell factories are becoming a norm for commercially viable production of chemicals for pharmaceutical, biotechnology, food and beverage industries (Borodina et al, 2015;Chen and Nielsen, 2013;Choi et al, 2015;Lee et al, 2012;Pfleger et al, 2015). However, engineering of microbial cell factories requires a simultaneous optimization of several criteria such as productivity, yield, titer, stress tolerance, all the while retaining the efficient, cost-effective and robust process.…”

Section: Introductionmentioning

confidence: 99%

Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Andreozzi

Chakrabarti

Soh

et al. 2016

Metabolic Engineering

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Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using largescale kinetic models, Metabolic Engineering, http://dx.doi.org/10. 1016/j.ymben.2016.01.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Entities) to analyze the physiology of recombinant E. coli producing 1,4-butanediol (BDO) and to identify potential strategies for improved production of BDO. The framework allowed us to integrate data across multiple levels and to construct a population of large-scale kinetic models despite the lack of available information about kinetic properties of every enzyme in the metabolic pathways. We analyzed these models and we found that the enzymes that primarily control the fluxes leading to BDO production are part of central glycolysis, the lower branch of tricarboxylic acid (TCA) cycle and the novel BDO production route. Interestingly, among the enzymes between the glucose uptake and the BDO pathway, the enzymes belonging to the lower branch of TCA cycle have been identified as the most important for improving BDO production and yield. We also quantified the effects of changes of the target enzymes on other intracellular states like energy charge, cofactor levels, redox state, cellular growth, and byproduct formation.Independent earlier experiments on this strain confirmed that the computationally 3 obtained conclusions are consistent with the experimentally tested designs, and the findings of the present studies can provide guidance for future work on strain improvement. Overall, these studies demonstrate the potential and effectiveness of ORACLE for the accelerated design of microbial cell factories.

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“…F, a commercial product with a favourable market forecast (Dalin Yebo 2015), was considered as one of the top 12 platform chemicals derived from biomass in a report from the U.S. Department of Energy (Werpy et al 2004), which was updated 6 years later (Bozell and Petersen, 2010;De Jong et al 2012). F is an intermediate for manufacturing other chemicals (such as methylfuran, furfuryl alcohol, tetrahydrofurfuryl alcohol, tetrahydrofuran, methyltetrahydrofuran, or furoic acid), and has a potential for further conversion into fuel or fuel additives (Lange et al 2012;Yan et al 2014;Choi et al 2015). The current technology for F production, based on the acid hydrolysis of native xylan-containing raw materials, can be significantly improved in terms of yield and energy efficiency (Lange et al 2012;Cai et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Furfural production from birch hemicelluloses by two-step processing: a potential technology for biorefineries

et al. 2016

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Birch samples were subjected to non-isothermal autohydrolysis to obtain a solution of hemicellulosic saccharides and a solid phase mainly made up of cellulose and lignin. Based on kinetic modeling, operational conditions were identified which give rise to soluble saccharides and furfural derived from xylan in a yield of 80.5%. The soluble mixture was supplemented with 1% sulfuric acid and heated (directly or in the presence of methyl isobutyl ketone, MIBK) for furfural production. MIBK is used as an extraction agent to limit furfural consumption by side reactions. Operating in single phase at 170°C, up to 44.8% of the potential substrates were converted into furfural. In experiments performed in biphasic media, the effects of MIBK were assessed by empirical modeling and about 75% of the potential substrates were converted under selected conditions.

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Biorefineries for the production of top building block chemicals and their derivatives

Cited by 431 publications

References 81 publications

Integrating a Biorefinery into an Operating Kraft Mill

Integrating a Biorefinery into an Operating Kraft Mill

Identification of metabolic engineering targets for the enhancement of 1,4-butanediol production in recombinant E. coli using large-scale kinetic models

Furfural production from birch hemicelluloses by two-step processing: a potential technology for biorefineries

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