Bog blueberry anthocyanins alleviate photoaging in ultraviolet‐B irradiation‐induced human dermal fibroblasts

Bae, Ji‐Young; Lim, Soon Sung; Kim, Sun-Ju; Choi, Jung‐Suk; Park, Jinseu; Ju, Sung Mi; Han, Seoung Jun; Kang, Il‐Jun; Kang, Young‐Hee

doi:10.1002/mnfr.200800245

Cited by 89 publications

(62 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[77] Fruits of Vaccinium uliginosum (bog blueberry) reduces ROS production and act as an antioxidant. [78] Plants with their chemical constituents and possible molecular mechanisms are listed in Table 1.…”

Section: Plant Inhibitorsmentioning

confidence: 99%

Untitled

Garg

2017

IJGP

View full text Add to dashboard Cite

Skin ageing is a complex multifactorial process occurring in all living beings. It generally comprises two independent and distinct processes, i.e., intrinsic, age-dependent or chronological aging and premature aging, or photoaging which is the result of undue exposure of the skin to ultraviolet (UV) radiations. Photoaging can be prevented or the effects of photoaging can be reduced by the use of certain anti-aging and anti-wrinkle agents. The extracellular matrix (ECM) which forms the outermost part of skin comprises fibroblasts and proteins such as collagen and elastin. Degradation of ECM is directly linked to skin aging and is responsible for the increase in activity of certain enzymes such as collagenase, elastase, and hyaluronidase (HYAL) that are involved in skin aging. With aging there is decrease in the levels of elastin, collagen, and hyaluronic acid which leads to loss of strength and flexibility of skin and appear as wrinkles on the skin. Further, the increase in the activity of collagenase, elastase, and HYAL is triggered by the high levels of reactive oxygen species produced when the skin is exposed to excessive UV radiations leading to skin aging. Today, in the age of modern science and advanced technology, although many techniques such as laser rejuvenation, plastic surgery, and lots of synthetic products such as sunscreen lotions, creams are available yet, there is a place for natural, herbal anti-aging cosmetics. Various botanical extracts have the power to reduce the appearance of skin aging and enhance the beauty of the skin. Medicinal plants have several phytoconstituents such as polyphenols, alkaloids, tannins, saponins, carotenoids, and terpenoids which possess antioxidant properties and can be used in treating the signs of aging. Some plants contain phenolic compounds which have free-radical scavenging property and can suppress aging. Some plants or their extracts possess several other constituents that may have the capability of inhibiting various enzyme such as HYAL, elastase, and matrix metalloproteinases enzyme that play a major role in skin aging. Some of them may possess the free radical scavenging or antioxidant property to fight against the signs of aging. This review focuses on the compilation of medicinal plants and natural compounds as anti-aging and anti-wrinkling agents along with their chemical constituents based on their possible molecular mechanism of action. The present review will facilitate the scientists working in this area for the development of new anti-aging and anti-wrinkle formulations with better efficiency and safety.

show abstract

Section: Plant Inhibitorsmentioning

confidence: 99%

Untitled

Garg

2017

IJGP

View full text Add to dashboard Cite

show abstract

“…Bog blueberry (Vaccinium uliginosum L.) extract consists of cyanidin-3-glucoside, petunidin-3-glucoside, malvidin-3-glucoside, and delphinidin-3-glucoside as the major anthocyanins (Figure 7). Bog blueberry anthocyanins showed the protected against UVB-induced skin photoaging by blocking collagen destruction and inflammatory responses via transcriptional mechanisms of NF-κB and MAPK signaling (Bae et al, 2009).…”

Section: Anthocyaninsmentioning

confidence: 99%

Photoprotection of natural flavonoids

Saewan

Jimtaisong²

2013

J App Pharm Sci

View full text Add to dashboard Cite

Overexposure to ultraviolet (UV) radiation can cause a number of skin disorders such as erythema, edema, hyperpigmentation, immunosuppression, photoaging, and skin cancer. Since the level of UV radiation is increasing as a result of depletion of the stratospheric ozone and climate change, the protection of human skin against the harmful effects of UV radiation is an urgent need. Topical application of sunscreens is a strategy to protect the deleterious effect of UV radiation on the skin. Sunscreens today contain one or several synthetic UV filter molecules which protect the UV radiation exposed on the epidermis. These molecules are broadly divided into physical and chemical agents. Physical sunscreens reflect and scatter UVB, UVA and visible radiation. Chemical sunscreens act by absorbing ultraviolet radiation and re-emitting chemical energy as heat or light. Several synthetic UV filter molecules are available in the market but they have limited use because these active molecules may create adverse effects on human skin. Some information on possible photon induced reaction such as photoirritation, photosensitization and contact dermatitis by sunscreen products containing synthetic organic sunscreen agents. To overcome these side effects, naturally occurring compounds have gained considerable attention as photoprotective agents. Flavonoids, a group of natural occurring compounds, act as catalysts in the light phase of photosynthesis and as stress protectants in plant cells by scavenging reactive oxygen species (ROS). Natural flavonoids have the potential photoprotection because of their UV absorbing, their ability to act as direct and indirect antioxidants as well as anti-inflammatory and immunomodulatory agents which provide exciting platforms for the development of photoprotection. This review summarizes the structure and potential photoprotection activity of several natural flavonoids.

show abstract

“…Flavonoids and phenolic acids also exhibit anti-inflammatory, antihistamine, antiviral and vasodilatory properties. It is suggested that the high level of phenylopropanoid compounds strengthens wound tissue defenses against biotic and abiotic stresses (Afaq et al, 2007;Chiang et al, 2005;Bae et al, 2009). The simultaneous use of fibres, oil emulsion and seedcake extract from genetically modified flax plants promoted the healing of chronic skin ulcerations (Skórkowska-Telichowska et al, 2010).…”

Section: Fig 5 Scheme Of Flax Dressingmentioning

confidence: 99%