Booster dose vaccination for preventing hepatitis B

Comparison between two population-based hepatitis B serosurveys with an 8-year interval in Shandong Province, China

“…In this study, 65.59% of students in the 2014 survey were born after universal infant hepatitis B vaccination and 76.34% had received the hepatitis B vaccination. The necessity of hepatitis B vaccine booster doses among healthy individuals remains controversial (Poorolajal and Hooshmand, 2016). However, according to the present results, it may be necessary to provide hepatitis B vaccination to students over 18 years of age who have not completed three doses of hepatitis B vaccine and to conduct studies on the booster dose among those who have completed a full course of hepatitis B vaccine in infancy.…”

Seroprevalence of anti-HBs antibodies at young adulthood, before and after a booster vaccine dose, among medical personnel vaccinated in infancy

“…Thus, revaccination policies remain controversial and suboptimally informed by evidence, and practices vary from country to country [11,32]. In light of the lack of randomized clinical trials evaluating the anamnestic response to booster doses, a recent Cochrane Review concluded that there is no scientific evidence to support or reject the need for booster doses of HBV vaccine in healthy individuals with normal immune status [33]. Thus, the UK recommends a single booster dose 5 years after primary vaccination [34], while the US-CDC recommends that no routine booster is necessary [35].…”

Efficacy of antigen dosage on the hepatitis B vaccine response in infants born to hepatitis B-uninfected and hepatitis B-infected mothers

“…The necessity of HB vaccine boosters has been debated; in one report from the Viral Hepatitis Prevention Board, summarizing 27 studies, which followed-up subjects from 4 to 15 years of age, booster vaccination was shown to be unnecessary [18]. Other researchers have suggested the need for more clinical trials to test the necessity of boosters [19,20]. Most previous studies on recombinant HB vaccines have demonstrated long-term immunity against HB [21].…”