Brachial‐ankle pulse wave velocity and cardiovascular risk factors in the non‐diabetic and newly diagnosed diabetic Chinese: Guangzhou Biobank Cohort Study‐CVD

Xu, Lin; Jiang, Chao Qiang; Lam, Tai Hing; Xiao, Yue; Cheng, Kar Keung; Liu, Bin; Jin, Ya Li; Zhang, Wei Sen; Thomas, G. Neil

doi:10.1002/dmrr.1059

Cited by 21 publications

(18 citation statements)

References 31 publications

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“…With regard to lipid metabolism, we found that TG and HDL levels were related to baPWV in individuals without hypertension. Only TG levels remained associated with baPWV in the hypertensive group, a finding consistent with that of previous reports [43, 44]. …”

Section: Discussionsupporting

confidence: 92%

Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension

Meng

Sun

Wang

et al. 2013

Journal of Diabetes Research

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Aim. We investigated the relationship between brachial-ankle pulse wave velocity (baPWV) and glucose levels, insulin sensitivity, and beta-cell function in Chinese individuals with or without hypertension. Methods. We recruited 3137 nondiabetic individuals whose age, body mass index (BMI), glucose levels, blood pressure (BP), lipids, hemoglobin A1C (HbA1c), baPWV, and insulin levels were measured. Results. In normotensive group, 2 h glucose levels (β = 0.046, P < 0.001) associated with baPWV, showed a significant increase in patients with NG as compared to those with DM (P = 0.032). The hypertensive group showed no such differences. The Matsuda index (β = 0.114, P < 0.001) and HOMA-β (β = 0.045, P < 0.001) were negatively correlated with baPWV while lnHOMA-IR (β = 0.196, P = 0.076) and the Quantitative Insulin Sensitivity Check Index (QUICKI) (β = 0.226, P = 0.046) showed a borderline negative correlation. BaPWV significantly decreased (P = 0.032) with an increase in insulin sensitivity in individuals with both normal BP and glucose tolerance. Conclusions. BaPWV was significantly associated with 2 h glucose levels, insulin sensitivity and beta-cell function in normotensive population, whereas in hypertensive individuals, BP was the dominant factor influencing arterial stiffness. Individuals with abnormal insulin sensitivity in the absence of diabetes and hypertension are also at an increased risk of arterial stiffness.

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Section: Discussionsupporting

confidence: 92%

Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension

Meng

Sun

Wang

et al. 2013

Journal of Diabetes Research

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“…We found that, in T2DM patients, male gender (in T2DM patients with HT), duration of DM (in T2DM patients with HT) and MBP (in T2DM patients with and without HT) were independently, significantly and positively correlated with PWV, while BMI (in T2DM patients with and without HT) and eGFR (in T2DM patients with HT) were independently, significantly and inversely correlated with PWV. The correlation between these variables and arterial stiffness, as indicated by our results, were also seen in previous studies -male gender, (41,42) BP, (43,44) duration of DM, (45) eGFR (46) and BMI (47,48) -although the characteristics of the various study populations were different.…”

Section: Discussionsupporting

confidence: 88%

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Kotani

Yamada²

2014

smedj

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The Asia-Pacific region is facing an epidemic of type 2 diabetes mellitus (T2DM), paralleled by high rates of cardiovascular disease (CVD).(1,2) Hypertension (HT) remains a major risk factor for CVD in the region. On DNA oxidation, a hydroxyl group is added to the guanine molecule to form 8-hydroxyguanine, which on oxidative modification yields the product, 8-hydroxy-2'-deoxyguanosine (8-OHdG). (7,8) Hyperglycaemia promotes glucose oxidation and protein glycation, impairs DNA repair with resultant DNA cleavage, and generates reactive oxygen species, thereby leading to increased oxidative stress. (4,7,8) Similarly, HT is accompanied by the formation of advanced glycation end products, and thereby increased oxidative stress and DNA damage. (9,10) For these reasons, the measurement of 8-OHdG has been used by various researchers to evaluate the DNA oxidation associated with the pathophysiology of T2DM and HT. (4,(11)(12)(13)(14)(15)(16) A study by Nishikawa et al found that urinary 8-OHdG levels were increased in T2DM patients with poor glycaemic control, (4) while a study by Espinosa et al reported that urinary 8-OHdG levels were increased in patients with HT.However, Roselló-Lletí et al demonstrated that patients with HT and DM do not exhibit any differences with regard to 8-OHdG levels when compared to patients with HT but no DM.Espinosa et al also reported that 8-OHdG levels were reduced following antihypertensive treatment in patients with HT.(13) Studies suggest lowered urinary 8-OHdG levels upon intervention with antidiabetic agents in T2DM patients, Barengo and Tuomilehto reported that the presence of HT as a comorbidity in the hyperglycaemic state increased CVD

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“…The results we obtained in this study of subjects with intermediate cardiovascular risk factors and normal blood glucose metabolism do not agree with the majority of previously published studies; however, the study population characteristics and adjustment variables were different. In general, there is a positive association of the dysglycaemia indices used, HbA1c [7–9, 36–38], FPG [5, 36, 37] and PG [6], with parameters of arterial stiffness such as baPWV [7, 36], central artery PWV [37, 38], cfPWV [9] or CAVI [6]. Some studies have shown that the association of HbA1c with arterial stiffness is greater than that observed with FPG and PG [9, 37].…”

Section: Discussionmentioning

confidence: 99%

Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study

et al. 2017

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BackgroundEffect of prediabetes and normal glucose on arterial stiffness remains controversial. The primary aim of this study was to investigate the relationship of fasting plasma glucose (FPG), postprandial glucose (PG) and glycosylated haemoglobin (HbA1c) with brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) in Caucasian adults. The secondary aim was to analyse this relationship by glycaemic status.MethodsCross-sectional study. Setting: Primary care. Participants: 2,233 subjects, 35–74 years. Measures: FPG (mg/dL) and HbA1c (%) of all subjects were measured using standard automated enzymatic methods. PG (mg/dL) was self-measured at home two hours after meals (breakfast, lunch and dinner) for one day using an Accu-chek ® glucometer. CAVI was measured using a VaSera VS-1500® device (Fukuda Denshi), and baPWV was calculated using a validated equation.ResultsCAVI and baPWV values were significantly higher in subjects with diabetes mellitus than in glucose normal and prediabetes groups (p<0.001). FPG, PG and HbA1c were positively associated with CAVI and baPWV. The β regression coefficient for: HbA1c was 0.112 (CI 95% 0.068 to 0.155) with CAVI, 0.266 (CI 95% 0.172 to 0.359) with baPWV; for PG was 0.006 (CI 95% 0.004 to 0.009 and for FPG was 0.005 (CI 95% 0.002 to 0.008) with baPWV; and for PG was 0.002 (CI 95% 0.001 to 0.003) and 0.003 (CI 95% 0.002 to 0.004) with CAVI (p<0.01 in all cases). When analysing by hyperglycaemic status, FPG, PG and HbA1c were positively associated with CAVI and baPWV in subjects with type 2 diabetes mellitus.ConclusionFPG, PG and HbA1c show a positive association with CAVI and baPWV, in Caucasian adults with intermediate cardiovascular risk factors. When analysing by hyperglycaemic status, the association is only maintained in subjects with type 2 diabetes mellitus.Trial registrationClinical Trials.gov Identifier: NCT01428934. Registered 2 September 2011. Retrospectively registered. Last updated September 8, 2016.

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Brachial‐ankle pulse wave velocity and cardiovascular risk factors in the non‐diabetic and newly diagnosed diabetic Chinese: Guangzhou Biobank Cohort Study‐CVD

Abstract: In the normoglycaemic and IGM subjects, after adjusting for age, blood pressure and other confounders, increasing HbA(1c) was associated with increased baPWV, suggesting a pathophysiological role of chronic glycaemia that can contribute to vascular disease risk in persons without diabetes.

Cited by 21 publications

References 31 publications

Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension

Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study

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