Cardiovascular risk profile of patients with psoriatic arthritis compared to controls--the role of inflammation

Abstract

These data support the hypothesis that PsA may be associated with obesity, hypertension, dyslipidaemia and insulin resistance because of the shared inflammatory pathway.

Prevalence of metabolic syndrome and degree of cardiovascular disease risk in patients with Psoriatic Arthritis

“…Regardless of the applied criteria for MetS, significant between-group differences existed. A limited number of previous studies have indicated that the prevalence of MetS in patients with PsA is between 23.5% and 58.1% (21)(22)(23)(24). There is one study that investigated the prevalance of MetS in a small number of patients with PsA in Turkey (9).…”

Cardiovascular risk and inflammatory rheumatic diseases

“…There is an increased prevalence of obesity, hypertension and diabetes mellitus in patients with PsA when compared to healthy controls. 15 The inflammatory process may also increase the risk of CVD in PsA; one report found that levels of CRP and ESR were associated with increased carotid intima medial thickness and endothelial dysfunction. 16 As is the case for PsA, no conclusive studies have been published on CVD risk factors in AS.…”

Management of patients with psoriatic arthritis

“…В целом следует принимать во внимание особо отмеченные в рекомендациях гепатоток-сичность МТ и риск развития инфекций при лечении ГИБП. При ПсА указано наличие риска развития кардио-васкулярной патологии, причем заболевания сердечно-сосудистой системы встречаются у больных ПсА чаще, чем в популяции [58]. На течение заболевания и перено-симость лечения влияют потребление алкоголя, СД 2-го типа, ожирение и стеатогепатоз.…”