Cohort Profile: The Guangzhou Biobank Cohort Study, a Guangzhou–Hong Kong–Birmingham collaboration

Jiang, Chaoqiang; Thomas, G. Neil; Lam, Tai Hing; Schooling, CM; Zhang, Weisen; Lao, Xiang Qian; Adab, Peymané; Liu, Bin; Leung, Gabriel M.; Cheng, Kar Keung

doi:10.1093/ije/dyl131

Cited by 215 publications

(244 citation statements)

References 35 publications

(10 reference statements)

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“…Movement sensors such as accelerometers have grown in popularity recently as a measure of physical activity [9], not only due to their objective measurements, but also due to their relatively small and unobtrusive size. Nevertheless, due to their high costs, accelerometers are not usually practical in large-scale cohort studies and instead questionnaires are frequently used to obtain physical activity data [10,11]. …”

Section: Introductionmentioning

confidence: 99%

Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic review

Lee

Macfarlane

Lam

et al. 2011

Int J Behav Nutr Phys Act

2,058

1,419

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BackgroundThe International Physical Activity Questionnaire - Short Form (IPAQ-SF) has been recommended as a cost-effective method to assess physical activity. Several studies validating the IPAQ-SF have been conducted with differing results, but no systematic review of these studies has been reported.MethodsThe keywords "IPAQ", "validation", and "validity" were searched in PubMed and Scopus. Studies published in English that validated the IPAQ-SF against an objective physical activity measuring device, doubly labeled water, or an objective fitness measure were included.ResultsTwenty-three validation studies were included in this review. There was a great deal of variability in the methods used across studies, but the results were largely similar. Correlations between the total physical activity level measured by the IPAQ-SF and objective standards ranged from 0.09 to 0.39; none reached the minimal acceptable standard in the literature (0.50 for objective activity measuring devices, 0.40 for fitness measures). Correlations between sections of the IPAQ-SF for vigorous activity or moderate activity level/walking and an objective standard showed even greater variability (-0.18 to 0.76), yet several reached the minimal acceptable standard. Only six studies provided comparisons between physical activity levels derived from the IPAQ-SF and those obtained from objective criterion. In most studies the IPAQ-SF overestimated physical activity level by 36 to 173 percent; one study underestimated by 28 percent.ConclusionsThe correlation between the IPAQ-SF and objective measures of activity or fitness in the large majority of studies was lower than the acceptable standard. Furthermore, the IPAQ-SF typically overestimated physical activity as measured by objective criterion by an average of 84 percent. Hence, the evidence to support the use of the IPAQ-SF as an indicator of relative or absolute physical activity is weak.

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Section: Introductionmentioning

confidence: 99%

Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic review

Lee

Macfarlane

Lam

et al. 2011

Int J Behav Nutr Phys Act

2,058

1,419

View full text Add to dashboard Cite

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“…To prevent contamination, all subjects received a unique identifier, which was used to barcode all items including the questionnaires, blood tubes and cryovials. The 1996 volunteers received a full medical checkup including measurement of blood pressure, obesity indices (body mass index (BMI), waist and hip circumferences, percentage body fat), 1 lung function (forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), 6 physical function measures (2.5 m get-up-and-go, left and right hand grip strength), chest X-ray and a range of vascular disease surrogate markers as described in Table 1.…”

Section: Physical Examinationmentioning

confidence: 99%

“…An outline of this cohort has been published previously. 1 Recruitment of 30 000 older Chinese subjects aged over 50 years for the study began in September 2003 and was completed in early 2008. We are currently initiating the first follow-up of the subjects to collect data on morbidity and mortality, and are also recalling them to the hospital for a repeat of the measures taken 5 years earlier.…”

Section: Introductionmentioning

confidence: 99%

“…1 Guangzhou is the provincial capital of Guangdong Province which has a population of 83 million permanent residents and 30 million migrants. 2 Guangdong, and in particular Guangzhou, is undergoing massive economic development.…”

Section: Introductionmentioning

confidence: 99%

“…These include lifestyle factors such as the maintenance of traditional cuisine and minimal consumption of tobacco products and alcohol in women, and psychosocial factors such as traditional belief in the need for a diet that balances Yin (cold/dark) and Yang (hot/bright) foods and offsets such imbalance in the body or the health benefits of obesity, which in developing countries is advantageous to help overcome childhood infections, including diarrhoeal disease. 1,6 Such a legacy means this population is an ideal setting to assess, both crosssectionally and longitudinally, the impact of rapid economic development on health determinants.…”

Section: Introductionmentioning

confidence: 99%

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An overview of the Guangzhou Biobank Cohort Study–Cardiovascular Disease Subcohort (GBCS-CVD): a platform for multidisciplinary collaboration

et al. 2009

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The Guangzhou Biobank Cohort Study (GBCS, n ¼ 30 519, age X50 years) was established to examine the effects of genetic and environmental influences on health problems and chronic disease development. Guangzhou is undergoing massive economic development, but from a baseline that had remained unchanged for millennia. The Cardiovascular Disease Subcohort (GBCS-CVD) consists of 2000 participants who have been intensively phenotyped including a range of surrogate markers of vascular disease, including carotid artery intima-media thickness, cerebral artery stenoses, arterial stiffness, ankle-to-brachial blood pressure index and albuminuria, as well as coagulatory and inflammatory markers. Plasma and leukocytes are stored in liquid nitrogen for future studies. Preliminary demographic data show the female volunteers are younger than the male ones, but present with greater levels of adiposity including central obesity (31 vs 16%). Women had more body fat (33 vs 24%) and associated levels of adipokines. Despite this, body mass index and hip circumferences were similar, which contrasts with Caucasian populations. Men had more physician-diagnosed vascular disease (6.1 vs 2.5%), hypertension (42 vs 34%) and hyperglycaemia (36.6 vs 29.6%) than the women, but were less insulin resistant. In men, smoking (40 vs 2%) and drinking alcohol (67 vs 50%) was more common and they also had lower energy expenditures. The genotype distributions of the 15 typed single nucleotide polymorphisms were all in HardyWeinberg equilibrium. This article describes the rationale and methodology for the study. Given the comprehensive characterization of demographic and psychosocial determinants and biochemistry, the study provides a unique platform for multidisciplinary collaboration in a highly dynamic setting.

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DNA Bank

Sivakumaran¹,

Iyengar²

2005

Encyclopedia of Statistical Sciences

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Most diseases are multifactorial and are caused by a combination of genetic and environmental factors. Similarly, the way a person responds to a drug is also a complex trait that is influenced by many different genes. Paradigms to identify causative genetic variants responsible for disease or response to drugs are well described in the literature, and the following essential elements are required for successful completion of such studies: ( 1 ) rapid detection of genetic variation; ( 2 ) large number of samples of high quality with well‐characterized clinical data from participants, which includes longitudinal follow‐up for effect of treatment; ( 3 ) advanced informatics for storage and retrieval of samples and data; and ( 4 ) establishment of correlation between clinical and genetic data through modern statistical techniques. Although the basic conventions for sample collection in gene mapping were already established, it was only after completion of Human Genome Project and the initiation of the International HapMap Project that the need for large databases of well‐phenotyped study participants collected under unified protocols with DNA available was expressed. These endeavors resulted in the establishment of national and international DNA banks aimed initially at mapping specific disease entities, but later encompassing more global undertakings. Establishment of these DNA biobanks has not been without ethical, legal, and personal controversies, although their value to the biomedical research community is indisputable. The overall outcome of these initiatives is that the promise of personalized medicine is nearby, particularly for identification of the genetic variations responsible for drug response. We anticipate that clinical trials could perform genetic prescreening to exclude people who are unresponsive to treatment, which reduces side effects and increases the effectiveness of the drug for particular subgroups. This model is already being implemented for the P450 class of drugs, with the hope of more to come.

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Cohort Profile: The Guangzhou Biobank Cohort Study, a Guangzhou–Hong Kong–Birmingham collaboration

Cited by 215 publications

References 35 publications

Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic review

Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic review

An overview of the Guangzhou Biobank Cohort Study–Cardiovascular Disease Subcohort (GBCS-CVD): a platform for multidisciplinary collaboration

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