Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation

Yang, Hong; Liu, Yuexia; Liu, Xuanchen; Gu, Huihui; Zhang, Jing; Sun, Cheng

doi:10.1155/2020/7618506

Cited by 7 publications

(5 citation statements)

References 125 publications

(130 reference statements)

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“…The classical "three-zone" theory emphasizes the significance that the optimal survival of fat graft depends largely on adipose tissue regeneration after fat grafting 43 . It is noteworthy that mesenchymal stem cells (MSCs), such as ADSCs and BMSCs, are probably the seed cells for adipogenesis, attributing to their directional differentiation to a wide variety of cell lineages by adjusting cultivating methods 44 . As a critical MSC-specific property, differentiation potential fate is synergistically influenced by the transcriptome, proteome, immunophenotype, and immunomodulatory activities 45 .…”

Section: Adscs Adipogenic Differentiationmentioning

confidence: 99%

Deciphering the Emerging Roles of Adipocytes and Adipose-Derived Stem Cells in Fat Transplantation

Zhao

et al. 2021

Cell Transplant

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Autologous fat transplantation is widely regarded as an increasingly popular method for augmentation or reshaping applications in soft tissue defects. Although the fat transplantation is of simple applicability, low donor site morbidity and excellent biocompatibility, the clinical unpredictability and high resorption rates of the fat grafts remain an inevitable problem. In the sites of fat transplantation, the most essential components are the adipocyte and adipose-derived stem cells (ADSCs). The survival of adipocytes is the direct factor determining fat retention. The efficacy of fat transplantation is reduced by fat absorption and fibrosis due to the inadequate blood flow, adipocyte apoptosis and fat necrosis. ADSCs, a heterogeneous mixture of cells in adipose tissue, are closely related to tissue survival. ADSCs exhibit the ability of multilineage differentiation and remarkable paracrine activity, which is crucial for graft survival. This article will review the recent existing research on the mechanisms of adipocytes and ADSCs in fat transplantation, especially including adipocyte apoptosis, mature adipocyte dedifferentiation, adipocyte browning, ADSCs adipogenic differentiation and ADSCs angiogenesis. The in-depth understanding of the survival mechanism will be extremely valuable for achieving the desired filling effects.

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Section: Adscs Adipogenic Differentiationmentioning

confidence: 99%

Deciphering the Emerging Roles of Adipocytes and Adipose-Derived Stem Cells in Fat Transplantation

Zhao

et al. 2021

Cell Transplant

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“…The Cancer Genome Atlas (TCGA) database contains the largest number of publicly available pan-digestive cancer samples and serves as a cornerstone for research. To date, 13 classical HATs and 18 HDACs have been documented in the human proteome [ 19 ], each of which is involved to varying degrees in the key steps of human physiological and pathological processes. However, the role of the HAT and HDAC gene families in the development of pan-digestive cancers remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Genetic and Molecular Characterization Revealed the Prognosis Efficiency of Histone Acetylation in Pan-Digestive Cancers

Zhang

Wang

et al. 2022

Journal of Oncology

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The imbalance between acetylation and deacetylation of histone proteins, important for epigenetic modifications, is closely associated with various diseases, including cancer. However, knowledge regarding the modification of histones across the different types of digestive cancers is still lacking. The purpose of this research was to analyze the role of histone acetylation and deacetylation in pan-digestive cancers. We systematically characterized the molecular alterations and clinical relevance of 13 histone acetyltransferase (HAT) and 18 histone deacetylase (HDAC) genes in five types of digestive cancers, including esophageal carcinoma, gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. Recurrent mutations and copy number variation (CNV) were extensively found in acetylation-associated genes across pan-digestive cancers. HDAC9 and KAT6A showed widespread copy number amplification across five pan-digestive cancers, while ESCO2, EP300, and HDAC10 had prevalent copy number deletions. Accordingly, we found that HAT and HDAC genes correlated with multiple cancer hallmark-related pathways, especially the histone modification-related pathway, PRC2 complex pathway. Furthermore, the expression pattern of HAT and HDAC genes stratified patients with clinical benefit in hepatocellular carcinoma and pancreatic cancer. These results indicated that acetylation acts as a key molecular regulation of pan-digestive tumor progression.

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“…Over the past few years, significant progress has been made in determining the role of epigenetics in chondrocyte fate decision and in the pathogenesis of multiple chondropathies. Several excellent reviews have highlighted the functions of DNA methylation, histone modifications, and non-coding RNAs in regulating the biological behavior of chondrocytes (Furumatsu and Ozaki, 2010;Barter et al, 2012;Duan et al, 2015;Hata, 2015;Kim et al, 2015;Bhonde et al, 2016;Ramos and Meulenbelt, 2017;Haq et al, 2018;Allas et al, 2019;Ren et al, 2020;Yang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

Wan

Zhang

Yao

et al. 2021

Front. Cell Dev. Biol.

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The involvement of histone modifications in cartilage development, pathology and regeneration is becoming increasingly evident. Understanding the molecular mechanisms and consequences of histone modification enzymes in cartilage development, homeostasis and pathology provides fundamental and precise perspectives to interpret the biological behavior of chondrocytes during skeletal development and the pathogenesis of various cartilage related diseases. Candidate molecules or drugs that target histone modifying proteins have shown promising therapeutic potential in the treatment of cartilage lesions associated with joint degeneration and other chondropathies. In this review, we summarized the advances in the understanding of histone modifications in the regulation of chondrocyte fate, cartilage development and pathology, particularly the molecular writers, erasers and readers involved. In addition, we have highlighted recent studies on the use of small molecules and drugs to manipulate histone signals to regulate chondrocyte functions or treat cartilage lesions, in particular osteoarthritis (OA), and discussed their potential therapeutic benefits and limitations in preventing articular cartilage degeneration or promoting its repair or regeneration.

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Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation

Cited by 7 publications

References 125 publications

Deciphering the Emerging Roles of Adipocytes and Adipose-Derived Stem Cells in Fat Transplantation

Deciphering the Emerging Roles of Adipocytes and Adipose-Derived Stem Cells in Fat Transplantation

Genetic and Molecular Characterization Revealed the Prognosis Efficiency of Histone Acetylation in Pan-Digestive Cancers

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

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