Curcumin-Induced Apoptosis in Human Hepatocellular Carcinoma J5 Cells: Critical Role of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>Ca</mml:mtext><mml:mrow><mml:mtext>+2</mml:mtext></mml:mrow></mml:msup></mml:math>-Dependent Pathway

Wang, Wei‐Hsun; Chiang, I-Tsang; Ding, Kun; Chung, Jing‐Gung; Lin, Wuu-Jyh; Lin, Song-Shei; Hwang, Jeng-Jong

doi:10.1155/2012/512907

Cited by 36 publications

(30 citation statements)

References 25 publications

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“…The protein expressions of VEGF, MMP-2, MMP-9, IL-1β, IL-6, TNF-α, pNF-κB, and NF-κB were evaluated with western blotting assays as described by Wang et al (20). The protein expression was quantified by densitometry using ImageJ software version 1.50 (National Institutes of Health, Bethesda, MD, USA) in order to determine the density of regions of interest.…”

Section: Western Blotting a Total Of 2x10mentioning

confidence: 99%

Regorafenib diminishes the expression and secretion of angiogenesis and metastasis associated proteins and inhibits cell invasion via NF-κB inactivation in SK-Hep1 cells

Liu

Wang³

2017

Oncology Letters

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Abstract. The aim of the present study was to investigate the effects of regorafenib on the nuclear factor κ-light-chain-enhancer of activated B cells (NF)-κB-modulated expression of angiogenesis-and metastasis-associated proteins and cell invasion in human hepatocellular carcinoma SK-Hep1 cells. The SK-Hep1 cells were treated with different concentrations of NF-κB inhibitor 4-N-[2-(4-phenoxyphenyl) ethyl] quinazoline-4,6-diamine (QNZ) or regorafenib for 24 or 48 h. The effects of QNZ and regorafenib on cell viability, NF-κB activation, expression and secretion levels of angiogenesis-and metastasis-associated proteins and cell invasion were evaluated with MTT assays, western blotting, ELISA, gelatin zymography and cell invasion assays. The results demonstrated that QNZ and regorafenib significantly reduced the expression and secretion levels of the angiogenesis-and metastasis-associated proteins vascular endothelial growth factor, tumor necrosis factor-α, interleukin (IL)-1β, IL-6, matrix metalloproteinase (MMP)-2 and MMP-9, NF-κB activation and cell invasion. In conclusion, the inhibition of NF-κB activation induces anti-angiogenic and antimetastatic effects in SK-Hep1 cells. Regorafenib reduces the level of expression and secretion of angiogenesis-and metastasis-associated proteins and cell invasion through the suppression of NF-κB activation in SK-Hep1 cells.

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Section: Western Blotting a Total Of 2x10mentioning

confidence: 99%

Regorafenib diminishes the expression and secretion of angiogenesis and metastasis associated proteins and inhibits cell invasion via NF-κB inactivation in SK-Hep1 cells

Liu

Wang³

2017

Oncology Letters

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“…In the present study, curcumin significantly decreased the calcium ion accumulation in the sciatic nerve which could be a reason for protective effect of curcumin against vincristine-induced CIPN. Previous findings also indicate that curcumin possesses calcium inhibitory action (Wang et al, 2012).…”

Section: Discussionmentioning

confidence: 92%

Effect of curcumin in mice model of vincristine-induced neuropathy

Babu¹,

Prasanth²,

Bhaskar³

2014

Pharmaceutical Biology

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Context: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity. Objective: The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model. Materials and methods: Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. Results: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p50.001) and allodynia (p50.001); mechanical hyperalgesia (p50.001); functional loss (p50.001); and in the delayed phase of formalin test (p50.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p50.001) in antioxidant levels and in total calcium levels in vincristine-injected mice. Conclusion: Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristineinduced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.

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“…TMZ not only induces apoptosis but also triggers NF-ĸB activity in glioblastoma cells. Therapeutic efficacy of TMZ is limited because of overexpression of NF-ĸB-modulated anti-apoptotic proteins; inhibition of NF-ĸB activation sensitizes glioblastoma cells to TMZ (21,22). Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a potential anticancer agent because it induces apoptosis leading to tumor growth inhibition in cancer (23).…”

Section: Discussionmentioning

confidence: 99%

Amentoflavone Induces Apoptosis and Inhibits NF-ĸBmodulated Anti-apoptotic Signaling in Glioblastoma Cells

Yen

Hsieh

Liu

et al. 2018

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Curcumin-Induced Apoptosis in Human Hepatocellular Carcinoma J5 Cells: Critical Role ofCa+2-Dependent Pathway

Cited by 36 publications

References 25 publications

Regorafenib diminishes the expression and secretion of angiogenesis and metastasis associated proteins and inhibits cell invasion via NF-κB inactivation in SK-Hep1 cells

Regorafenib diminishes the expression and secretion of angiogenesis and metastasis associated proteins and inhibits cell invasion via NF-κB inactivation in SK-Hep1 cells

Effect of curcumin in mice model of vincristine-induced neuropathy

Amentoflavone Induces Apoptosis and Inhibits NF-ĸBmodulated Anti-apoptotic Signaling in Glioblastoma Cells

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