Cutaneous angiosarcoma: a current update

Shustef, Elina; Kazlouskaya, Viktoryia; Prieto, Víctor G.; Ivan, Doina; Aung, Phyu P.

doi:10.1136/jclinpath-2017-204601

Cited by 102 publications

(120 citation statements)

References 105 publications

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“…Angiosarcomas are rare soft‐tissue sarcomas and account for 12% of radiotherapy‐induced neoplasia . CA shows an extremely poor prognosis, and the reported overall 5‐year survival rate is low, ranging from 12% to 34% (median survival 18–28 months) .…”

Section: Discussionmentioning

confidence: 99%

“…CA shows an extremely poor prognosis, and the reported overall 5‐year survival rate is low, ranging from 12% to 34% (median survival 18–28 months) . Radiation‐associated CAs are a common complication of radiotherapy in breast and gynecologic cancer patients . The mean latency time between radiotherapy and the development of sarcoma is 10 years on average, and the incidence rate tends to increase with radiotherapy doses above 60 Gy .…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis of CAs can be made by history and skin biopsy, but early recognition is difficult due to the long latency period of 10 years on average and slow, progressive development . Despite aggressive treatment, such as a combination of surgery and radiotherapy, CAs have an extremely poor prognosis and high local recurrence and metastatic tendencies . Therefore, patients treated with radiotherapy should be followed up for extended periods, and it is important to provide appropriate treatment through early diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Radiation‐induced cutaneous angiosarcoma of the abdomen in a patient with cervical cancer: A case report

Shin

Choi

2019

J of Obstet and Gynaecol

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Cutaneous angiosarcoma (CA) is a rare and aggressive malignant tumor that develops from vascular endothelium. Secondary CAs are often caused by radiotherapy and chronic lymphedema. Most radiation-induced CAs are associated with breast or gynecologic cancer. The prognosis of CA is extremely poor, with a 5-year survival rate ranging from 12% to 34%. Therapeutic options are limited, and surgical excision with negative margins remains the mainstay of treatment. We report a case of a 63-year-old woman who developed secondary CA at an irradiated site 7 years after receiving radiotherapy for cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radiation‐induced cutaneous angiosarcoma of the abdomen in a patient with cervical cancer: A case report

Shin

Choi

2019

J of Obstet and Gynaecol

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“…Well-differentiated morphology has been traditionally thought to contribute to the better outcomes of eyelid angiosarcoma [8]. However, the current body of evidence suggests that angiosarcoma grading is not prognostic for cutaneous angiosarcoma [17]. …”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Angiosarcoma of the Eyelid: A Diagnostic and Therapeutic Challenge

et al. 2018

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Primary cutaneous angiosarcoma is a rare vasoformative malignant neoplasm that can present a diagnostic and therapeutic challenge. We describe a 76-year-old Caucasian man with right upper eyelid swelling and nodularity, initially suspected clinically to represent either ocular adnexal lymphoma or basal cell carcinoma. Incisional biopsy and wide resection of the mass with frozen section control of margins were interpreted as compatible with hobnail (Dabska-retiform) hemangioendothelioma. Foci of atypia were noted in the tumor, raising speculation of evolution into a more aggressive neoplasm, such as conventional angiosarcoma. The patient subsequently underwent two additional wide resections with frozen section control of margins in an attempt to obtain complete excision of residual tumor, which demonstrated histopathologic features favoring angiosarcoma. The histologic material from the original and subsequent resections was sent in consultation to several soft tissue pathology experts and the final diagnosis of low-grade cutaneous angiosarcoma was established. Despite repeated surgical interventions, there was continued persistence of the tumor in the deep orbital tissues. Various management options, including adjuvant radiotherapy/chemotherapy with and without orbital exenteration, were discussed. The patient decided against further surgical intervention and is currently undergoing adjuvant radiotherapy/chemotherapy. This case illustrates the diagnostic and management difficulties of ocular adnexal angiosarcoma.

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“…Chemotherapy can improve the outcome in metastatic disease . Furthermore, clinical trials employing targeted therapies such as tyrosine kinase inhibitors (pazopanib, sorafenib, axitinib), VEGFR inhibitor (bevacizumab), monoclonal antibody to endoglin (cartuximab), and a dual inhibitor of VEGFR2‐TIE2 tyrosine kinase (regorafenib) are currently underway …”

Section: Introductionmentioning

confidence: 99%

Post‐radiation vascular lesions of the breast

et al. 2018

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Post‐radiation vascular lesions are a rare complication most commonly seen in patients previously treated for breast cancer. The main two entities include angiosarcoma (AS), which are malignant tumors that have a poor prognosis, and atypical vascular lesions (AVL), which typically behave in a benign manner and only rarely progress to angiosarcoma. The overall incidence of these lesions is low, but it appears to be increasing. Histopathologic distinction of AVL and AS is essential due to different clinical outcomes and treatment. However, due to the occasional existence of overlapping clinical and histopathologic features, it may be sometimes difficult to render a definite diagnosis, particularly in small biopsies. Ancillary techniques are, in general, of little help for separating the borderland cases but, in some instances, immunohistochemical study (IHC) for Ki67 and IHC or fluorescence in situ hybridization analysis for MYC may help in the diagnosis of angiosarcoma. Herein we discuss the clinical characteristics, histopathologic features, management strategies, and outcome of these lesions, with special emphasis on their differential diagnosis.

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Cutaneous angiosarcoma: a current update

Cited by 102 publications

References 105 publications

Radiation‐induced cutaneous angiosarcoma of the abdomen in a patient with cervical cancer: A case report

Radiation‐induced cutaneous angiosarcoma of the abdomen in a patient with cervical cancer: A case report

Primary Cutaneous Angiosarcoma of the Eyelid: A Diagnostic and Therapeutic Challenge

Post‐radiation vascular lesions of the breast

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