Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment

Carpenter, Linda L.; Carvalho, John; Tyrka, Audrey R.; Wier, Lauren M; Mello, Andréa F.; Mello, Marcelo Feijó de; Anderson, George M.; Wilkinson, Charles W.; Price, Lawrence H.

doi:10.1016/j.biopsych.2007.05.002

Cited by 479 publications

(406 citation statements)

References 75 publications

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“…This prediction was particularly significant in T-allele carriers (N = 77, AUC = 0.76). The relevance of inclusion of childhood trauma in this model is in line with previous studies showing the effects of childhood trauma on HPA-axis activity (Yehuda et al, 1991;Carpenter et al, 2007;Lovallo et al, 2012;Heim et al, 2000). A new predictor rule derived from the baseline SKA2 methylation that again included childhood trauma, also predicted PTSD symptoms with fairly good accuracy (AUC = 0.85, po0.001).…”

Section: Discussionsupporting

confidence: 84%

SKA2 Methylation is Involved in Cortisol Stress Reactivity and Predicts the Development of Post-Traumatic Stress Disorder (PTSD) After Military Deployment

Boks

Rutten

Geuze

et al. 2015

Neuropsychopharmacol

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Genomic variation in the SKA2 gene has recently been identified as a promising suicide biomarker. In light of its role in glucocorticoid receptor transactivation, we investigated whether SKA2 DNA methylation influences cortisol stress reactivity and is involved in the development of post-traumatic stress disorder (PTSD). Increased SKA2 methylation was significantly associated with lower cortisol stress reactivity in 85 healthy individuals exposed to the Trier Social Stress Test (B = − 173.40, t = − 2.324, p-value = 0.023). Next, we observed that longitudinal decreases in SKA2 methylation after deployment were associated with the emergence of post-deployment PTSD symptoms in a Dutch military cohort (N = 93; B = − 0.054, t = − 3.706, p-value = 3.66 × 10 − 4 ). In contrast, exposure to traumatic stress during deployment by itself resulted in longitudinal increases in SKA2 methylation (B = 0.037, t = 4.173, p-value = 6.98 × 10 − 5 ). Using predeployment SKA2 methylation levels and childhood trauma exposure, we found that the previously published suicide prediction rule significantly predicted post-deployment PTSD symptoms (AUC = 0.66, 95% CI: 0.53-0.79) with an optimal sensitivity of 0.81 and specificity of 0.91. Permutation analysis using random methylation loci supported these findings. Together, these data establish the importance of SKA2 for cortisol stress responsivity and the development of PTSD and provide further evidence that SKA2 is a promising biomarker for stress-related disorders including PTSD.

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Section: Discussionsupporting

confidence: 84%

SKA2 Methylation is Involved in Cortisol Stress Reactivity and Predicts the Development of Post-Traumatic Stress Disorder (PTSD) After Military Deployment

Boks

Rutten

Geuze

et al. 2015

Neuropsychopharmacol

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“…Elzinga et al [14] found that adverse childhood events in healthy young males are associated with changes in HPA axis function. This is similar to Carpenter et al [5], who found a diminished HPA axis in 23 healthy adults with maltreated childhood.…”

Section: Introductionsupporting

confidence: 87%

Suicide attempters: biological stressmarkers and adverse life events

Sunnqvist

Westrin

Träskman‐Bendz

2008

Eur Arch Psychiatry Clin Neurosc

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j Abstract Risk factors for suicidal behaviour include adverse life events as well as biochemical parameters acting, e.g. within the hypothalamic-pituitary-adrenal axis and/or monoaminergic systems. The aim of the present investigation was to study stressful life events and biological stress markers among former psychiatric inpatients, who were followed up 12 years after an index suicide attempt. At the time of the index suicide attempt, and before treatment, cerebrospinal fluid (CSF) samples were taken, and 24 h (h) urine (U) was collected. 3-Methoxy-4-hydroxyphenylglycole (MHPG) in CSF and 24 h urinary samples of cortisol and noradrenaline/adrenaline (NA/A) were analysed. Data concerning stressful life events were collected retrospectively from all participants in the study through semi-structured interviews at follow-up. We found that patients who reported sexual abuse during childhood and adolescence had significantly higher levels of CSF-MHPG and U-NA/A, than those who had not. Low 24 h U-cortisol was associated with feelings of neglect during childhood and adolescence. In conclusion, this study has shown significant and discrepant biological stress-system findings in relation to some adverse life events. j Key words suicide attempt AE catecholaminergic markers AE U-cortisol AE adverse life events

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“…One underlying biological mechanism, a dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, a major stress response in the human body, is discussed. Long-term alterations in the regulation of the HPA axis and its final product, cortisol, are a known consequence of the enormous stress caused by maltreatment during childhood (Carpenter et al, 2007), and are linked to health outcomes such as cancer and cardiovascular and metabolic diseases (Kumari, Shipley, Stafford, & Kivimaki, 2011; Volden & Conzen, 2013). Furthermore, chronic inflammatory processes, encompassing increased levels of pro-inflammatory cytokines and oxidative stress, are a demonstrated long-term consequence of child maltreatment (Boeck et al, 2016) and are known to play a role in the pathomechanisms of cancer (Taniguchi & Karin, 2018), cardiovascular diseases (Harrington, 2017), diabetes and other metabolic diseases (Herder et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Clemens

Huber‐Lang

Plener

et al. 2018

European Journal of Psychotraumatology

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Background: Child maltreatment is a major public problem, associated with enormous consequences on the individual and socioeconomic level. Studies show a clear impact of child maltreatment on long-term physical health. However, there is a lack of analyses comprising a wide variety of subtypes of maltreatment and addressing cumulative effects of different maltreatment subtypes experienced during childhood on physical health. Objective: The objective of this analysis was to assess the association of different subtypes and the intensity of child maltreatment with long-term physical health outcomes. Methods: In a cross-sectional observational approach, a representative sample of the German population (N=2510) was assessed regarding socioeconomic information, their current health status, and their experiences of child maltreatment using the Childhood Trauma Questionnaire (CTQ). Chi2-Tests were performed to compare differences of physical health conditions in adulthood in association with child maltreatment and binary regression analyses to assess the relationship of physical health and number of different subtypes of maltreatment experienced during childhood. Results: Odds increased significantly for obesity (1.8), diabetes (1.26), cancer (1.28), hypertension (1.16), chronic obstructive pulmonary disease (1.51), history of myocardial infarction (1.29) and stroke (1.31) with increasingenhancing number of experienced subtypes of child maltreatment. Growing intensity of each subtype of maltreatment was associated with higher rates of all assessed physical health conditions, which could point towards a dose-dependency of the relationship between maltreatment and long-term physical health. Conclusions: Child maltreatment is associated with increased odds for the leading morbidity and mortality causes in Germany. Interventions encompassing secondary and primary preventive strategies are critical to target this major public health problem and its devastating consequences.

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Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment

Abstract: In adults without diagnosable psychopathology, childhood maltreatment is associated with diminished HPA axis response to a psychosocial stressor. Possible explanations for the finding are discussed.

Cited by 479 publications

References 75 publications

SKA2 Methylation is Involved in Cortisol Stress Reactivity and Predicts the Development of Post-Traumatic Stress Disorder (PTSD) After Military Deployment

SKA2 Methylation is Involved in Cortisol Stress Reactivity and Predicts the Development of Post-Traumatic Stress Disorder (PTSD) After Military Deployment

Suicide attempters: biological stressmarkers and adverse life events

Association of child maltreatment subtypes and long-term physical health in a German representative sample

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