Depression and resting state heart rate variability in children and adolescents — A systematic review and meta-analysis

Koenig, Julian; Kemp, Andrew H.; Beauchaine, Theodore P.; Thayer, Julian F.; Kaess, Michael

doi:10.1016/j.cpr.2016.04.013

Cited by 207 publications

(183 citation statements)

References 123 publications

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“…In line with results from the previous meta-analysis, we found no statistical significant correlation between self-reported depression severity and RVA in the entire sample including non-depressed controls. Again, the direction and magnitude of the effect (see Supplementary Material and Figure 1) was similar to the one reported in the meta-analysis (Koenig et al , 2016). …”

Section: Discussionsupporting

confidence: 82%

“…However, the effect was in the same direction and the magnitude was within the 95% CI of the exiting results from meta-analyses (Kemp et al 2010; Koenig et al , 2016). The present study included a diverse (heterogeneity in sex, medication status and comorbidity) sample of adolescents with MDD, which might partially explain why group-level comparisons did not reach the set level of significance.…”

Section: Discussionsupporting

confidence: 51%

“…MDD is characterized by differences in brain structure, including some evidence of abnormal cortical thickness (Kempton et al , 2011; Sacher et al , 2012). Independent of age, MDD is associated with autonomic nervous system (ANS) dysfunction, indexed by decreased resting state vagal activity (RVA) (Kemp et al , 2010; Koenig et al , 2016). In healthy adults, greater RVA is associated with greater cortical thickness of the prefrontal cortex (PFC) and anterior cingulate cortex (ACC) (Winkelmann et al , 2016; Yoo et al , 2018).…”

Section: Introductionmentioning

confidence: 99%

“…MDD-related changes in cortical thickness, particularly in regions of the fronto-limbic network, may explain differences in the top-down control of cardiac function resulting in decreased resting state RVA and increased autonomic arousal observed in depressed children, adolescents (Koenig et al , 2016) and adults (Kemp et al , 2010). The ANS is separated into two branches: the parasympathetic nervous system (PNS) and the sympathetic nervous system (SNS).…”

Section: Introductionmentioning

confidence: 99%

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Brain structural thickness and resting state autonomic function in adolescents with major depression

Koenig

Schreiner

Klimes‐Dougan

et al. 2018

Social Cognitive and Affective Neuroscience

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Major depressive disorder (MDD) has been associated with abnormalities in cortical thickness and autonomic function. Adolescence is a time notable for brain development and MDD onset. In healthy adolescents, greater resting state vagal activity (RVA) is associated with lower cortical thickness. The relationship between brain structural thickness and RVA in adolescents with MDD has not previously been studied. This secondary analysis drew on a sample of 37 non-depressed controls and 53 adolescents with MDD. Resting state heart rate and two indices of RVA (HF-HRV and RMSSD) were recorded during a neuroimaging session. Cortical thickness within fronto-limbic regions of interest was measured using Freesurfer analysis of T1-weighted high-resolution structural images. Self-reports of depression severity showed a significant interaction with cortical thickness of the right insula in predicting RMSSD [t = 2.22, P=0.030, β = 5.44; model fit of the interaction term as indicated by the ‘Bayes Factor’ (BF): 7.58] and HF-HRV (t = 2.09, P=0.041, β = 4.72; BF: 7.94). Clinician ratings of depression severity showed further interactions. Findings underscore the important relationships between RVA and cortical development, suggesting two possible explanations: (i) in adolescent MDD, greater fronto-limbic thickness is compensatory for deficits in autonomic regulation or (ii) increased autonomic arousal results in delayed fronto-limbic maturation. Longitudinal research is necessary to further clarify the nature of the relationship between autonomic functioning and cortical development.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Brain structural thickness and resting state autonomic function in adolescents with major depression

Koenig

Schreiner

Klimes‐Dougan

et al. 2018

Social Cognitive and Affective Neuroscience

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“…Chronic reductions in vagal activity indexed by HRV are associated with poor physiological, emotional, cognitive, behavioral regulation and self-rated heath (Alvares et al 2013; Beauchaine and Thayer 2015; Jarczok et al 2015; Thayer and Lane 2000; Thayer et al 2012; Thayer et al 2009a; Thayer and Lane 2009), as well as psychopathology (Kemp et al 2010; Koenig et al 2015, 2016; Clamor et al 2016). Functional neuroimaging studies and human lesion studies have shown several brain regions and networks involved in the neural control of HRV (Thayer et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples

et al. 2017

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Previous research has shown associations between brain structure and resting state high-frequency heart rate variability (HF-HRV). Age affects both brain structure and HF-HRV. Therefore we sought to examine the relationship between brain structure and HF-HRV as a function of age. Data from two independent studies were used for the present analysis. Study 1 included 19 older adults (10 males, age range 62–78 years) and 19 younger adults (12 males, age range 19–37). Study 2 included 23 older adults (12 males; age range 55–75) and 27 younger adults (17 males; age range 18–34). The root-mean-square of successive R-R-interval differences (RMSSD) from ECG recordings was used as time-domain measure of HF-HRV. MRI scans were performed on a 3.0-T Siemens Magnetom Trio scanner. Cortical reconstruction and volumetric segmentation were performed with the Freesurfer image analysis suite, including 12 regions as regions-of-interests (ROI). Zero-order and partial correlations were used to assess the correlation of RMSSD with cortical thickness in selected ROIs. Lateral orbitofrontal cortex (OFC) cortical thickness was significantly associated with RMSSD. Further, both studies, in line with previous research, showed correlations between RMSSD and anterior cingulate cortex (ACC) cortical thickness. Meta-analysis on adjusted correlation coefficients from individual studies confirmed an association of RMSSD with the left rostral ACC and the left lateral OFC. Future longitudinal studies are necessary to trace individual trajectories in the association of HRV and brain structure across aging.

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Physiological linkage and affective dynamics in dyadic interactions between adolescents and their mothers

McKillop

Connell

2018

Developmental Psychobiology

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This study examined physiological linkage (specifically, linkage in respiratory sinus arrhythmia; RSA) between parents and youth (aged 11-17) across conflict and fun activity discussion tasks. We also examined whether observed, momentary negative affect or parental depressive symptoms, would moderate patterns of RSA linkage across the interaction tasks. RSA linkage was assessed using a multilevel actor-partner interdependence model (APIM). Participants were 59 mother-adolescent dyads, including mothers with or without clinically significant depressive symptoms. Both mothers and teens evidenced stable RSA over time (actor effect), although the stability of maternal RSA was moderated by maternal depression, with maternal depressive symptoms related to slower RSA return to baseline. There was a significant partner influence on youth RSA, with maternal RSA positively related to subsequent youth RSA. However, this effect was moderated by maternal depression and maternal negative affect (NA), with low maternal depression/low maternal NA related to dyadic synchrony, whereas high depression or high NA led to attenuation of this relationship. Results demonstrate the importance of understanding the dynamic and complex nature of family interactions in the context of depression.

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Depression and resting state heart rate variability in children and adolescents — A systematic review and meta-analysis

Cited by 207 publications

References 123 publications

Brain structural thickness and resting state autonomic function in adolescents with major depression

Brain structural thickness and resting state autonomic function in adolescents with major depression

Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples

Physiological linkage and affective dynamics in dyadic interactions between adolescents and their mothers

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