Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV‐B irradiation

Bae, Ji‐Young; Choi, Jung‐Suk; Kang, Sang‐Wook; Lee, Yongjin; Park, Jinseu; Kang, Young‐Hee

doi:10.1111/j.1600-0625.2009.01044.x

Cited by 153 publications

(84 citation statements)

References 32 publications

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“…Rather, it is possibly due to sunlight damage. 6,16 This study has shown that damaged limbal stem cells are not a factor in pterygium occurrence, which is also reported by Tsai et al 11 However the study by Pelit et al showed the contrary. 10 We think this may be because damaged limbal stem cells are not being eliminated by natural killer cells.…”

contrasting

confidence: 29%

“…Collagen degeneration served as an objective measure of excessive sunlight exposure. 16 And neoplastic cells, which may also express p53 12 as well as MMPs 5 may be confused with benign damaged cells. 7 Chronic inflammatory cells were investigated by immunohistochemistry using an antibody against leukocyte common antigen (LCA) and damaged limbal basal epithelial cells, using antibodies against p53 and MMP1, 2 and 3.…”

Section: Methodsmentioning

confidence: 99%

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Chronic inflammatory cells and damaged limbal cells in pterygium

Anguria

Carmichael²,

Ntuli³

et al. 2013

Afr H. Sci.

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Background: Chronic inflammation in pterygium occurrence has not been explained. Whether damaged limbal basal epithelial cells are associated with pterygium occurrence in black Africans is not clear. Objective: To explain chronic inflammation in pterygium, and to clarify whether damaged limbal basal epithelial cells were associated with pterygium occurrence in black Africans. Methods: Chronic inflammatory changes and damaged limbal basal epithelial cells were assessed in 59 samples. Results: Chronic inflammatory cells were present in 59 pterygia. Inflammatory cell count in 5 (27.8%) of 18 small pterygia was >200 (high) while in 22 (53.7%) of 41 large growths was <200 (low); p = 0.25. The proportion of pterygia with high counts tended to increase with pterygium extent. Twenty (33.9%) of 59 pterygia recurred after surgery. Ten (50%) of 20 samples had high cell counts and 10 (50%), low counts; p = 0.40. P53 expression was detected in 11 (18.6%) of 59 pterygium samples and 5 (71.4%) of 7 controls; p = 0.007. MMP 1 staining was present in 14 (23.7%) of 59 sections and 5 (71.4%) of 7 controls; p = 0.02. MMP2 in 16 (27.1%) cases and 5 (71.4%) controls; p = 0.03. MMP3 was overexpressed in 16 (27.1%) of 59 cases and 5 (71.4%) controls; p = 0.03. Conclusions: Mild chronic inflammation has a tendency to be more frequent than severe inflammation in pterygia. It is clear that damaged limbal basal epithelial cells are unlikely to be related to pterygium occurrence.

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contrasting

confidence: 29%

Section: Methodsmentioning

confidence: 99%

Chronic inflammatory cells and damaged limbal cells in pterygium

Anguria

Carmichael²,

Ntuli³

et al. 2013

Afr H. Sci.

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“…Study on rats showed a potentially good tolerability (Tasaki et al ., 2008). Ellagic acid prevents collagen destruction and inflammatory responses caused by UV‐B‐induced photoaging in HaCaT keratinocytes and human dermal fibroblasts (Bae et al ., 2010). …”

Section: Identification Of Candidatesmentioning

confidence: 99%

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

et al. 2016

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SummaryIn the coming decades, a massive shift in the aging segment of the population will have major social and economic consequences around the world. One way to offset this increase is to expedite the development of geroprotectors, substances that slow aging, repair age‐associated damage and extend healthy lifespan, or healthspan. While over 200 geroprotectors are now reported in model organisms and some are in human use for specific disease indications, the path toward determining whether they affect aging in humans remains obscure. Translation to the clinic is hampered by multiple issues including absence of a common set of criteria to define, select, and classify these substances, given the complexity of the aging process and their enormous diversity in mechanism of action. Translational research efforts would benefit from the formation of a scientific consensus on the following: the definition of ‘geroprotector’, the selection criteria for geroprotectors, a comprehensive classification system, and an analytical model. Here, we review current approaches to selection and put forth our own suggested selection criteria. Standardizing selection of geroprotectors will streamline discovery and analysis of new candidates, saving time and cost involved in translation to clinic.

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“…EA possesses a wide spectrum of pharmacological activities such as anticancer [20], antiallergic [21], antimalarial [22], antiwrinkle [23], antiglycative, anti-inflammatory [24], and antioxidant [25]. In fact, EA has been found to exhibit a potential scavenging action on superoxide anion and hydroxyl anion in vitro [26].…”

Section: Introductionmentioning

confidence: 99%

Quercetin and Ellagic Acid in Gastric Ulcer Prevention: An Integrated Scheme of the Potential Mechanisms of Action From in Vivo Study

Kotob

Sayed

Mohamed

et al. 2018

Asian J Pharm Clin Res

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Objective: The present study was initiated to describe the gastroprotective role of quercetin (Qu) and ellagic acid (EA) on aspirin-induced gastric ulcer (GU) in rats.Methods: Forty adult female albino rats of Wistar strain were distributed into: Control group, GU group, Omeprazole group, Qu group, and EA group. Gross examination, biochemical analyses including serum adrenocorticotropic hormone (ACTH), serotonin (ST), ferritin, heme oxygenase-1 (HO-1), interleukin-2 (IL-2), advanced glycosylation end products (AGEs), and fibronectin (FN) levels were estimated. Moreover, histopathological and histochemical examinations of stomach tissue samples were carried out.Results: Gross examination of gastric mucosa of rats in GU group revealed hyperemia of the stomach mucosa. Furthermore, rats in GU group experienced a significant rise in serum ACTH, ferritin, HO-1, IL-2 and AGEs levels accompanied with significant drop in serum ST and FN levels versus control counterparts. Pre-treatment of GU group with Omeprazole, Qu or EA caused marked improvement in the measured biochemical parameters. Histopathological and histochemical examinations of stomach tissue samples documented the protective action of Omeprazole, Qu and EA with different degrees against GU caused by aspirin. Conclusion:As a conclusion to this study, we can state that both Qu and EA have gastroprotective effect against aspirin-induced GU in rat model. Of note, Qu showed superior impact than EA as an antiulcer agent in this study. The corresponding mechanisms are speculated to be associated with inhibiting stress-induced gastric lesion, attenuating the oxidative stress, iron chelation and blunting ferritin level, modulating inflammatory cascade, and promoting the healing process.

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Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV‐B irradiation

Cited by 153 publications

References 32 publications

Chronic inflammatory cells and damaged limbal cells in pterygium

Chronic inflammatory cells and damaged limbal cells in pterygium

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

Quercetin and Ellagic Acid in Gastric Ulcer Prevention: An Integrated Scheme of the Potential Mechanisms of Action From in Vivo Study

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