Abstract:Dihydroceramide and NeurodegenerationTzou et al. Highlights Deficiency in dihydroceramide (dhCer) desaturase induces cytoplasmic ROS elevation dhCer alters the binding of active Rac1 to reconstituted organelle membranes Active Rac1 is enriched in endolysosomes in ifc-KO neurons for ROS genesis Rac1-NADPH oxidase elicits ROS, degenerating leukodystrophy-related neuronal cells Dihydroceramide and Neurodegeneration Tzou et al. Summary Disruption of sphingolipid homeostasis has been shown to cause neurolog… Show more
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