Dysbiosis of gut microbiota after cholecystectomy is associated with non‐alcoholic fatty liver disease in mice

Wang, Qihan; Lu, Qishao; Shao, Wentao; Jiang, Zhaoyan; Hu, Hai

doi:10.1002/2211-5463.13243

Cited by 7 publications

(4 citation statements)

References 42 publications

(49 reference statements)

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“…It has been widely reported that in the NAFLD, the OTUs of Lactobacillus were depleted in the NAFLD murine model, 46 and the Lactobacillus strains also exhibit beneficial influence on liver cholesterol metabolism and positive protective effects against NAFLD by producing short‐chain fatty acids, amino acid catabolites, and so on 47,48 . In agreement with other previous literature, the abundance of Parabacteroides and Bacteroides in the gut microbiota of NAFLD patients are higher than normal controls, which has been demonstrated to be related to fat accumulation 49‐51 . It also should be noted that several contradictory results in other studies showed Lachnospiraceae family is enriched in NAFLD patients 52 .…”

Section: Resultssupporting

confidence: 89%

“…47,48 In agreement with other previous literature, the abundance of Parabacteroides and Bacteroides in the gut microbiota of NAFLD patients are higher than normal controls, which has been demonstrated to be related to fat accumulation. [49][50][51] It also should be noted that several contradictory results in other studies showed Lachnospiraceae family is enriched in NAFLD patients. 52 The diverging results may be induced by multiple reasons, such as differences in disease severity, models or environments factors.…”

Section: Zw3 Alleviate Gut Microbiota Dysbiosis In Nafld Rat Induced ...mentioning

confidence: 97%

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Identification of a novel probiotic and its protective effects on NAFLD via modulating gut microbial community

Geng

Yang

et al. 2022

J Sci Food Agric

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BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is becoming the most common progressive liver diseases. Therapeutic strategy based on gut-liver axis and probiotics is a promising approach for the treatment of NAFLD. However, rare probiotics have been applied in NAFLD treatment, and the involved molecular mechanism is not entirely clear.RESULTS: We initially identified a novel functional probiotic, Lactobacillus kefiranofaciens ZW3, on the lipid deposition by a simple and rapid zebrafish model. Supplementation with ZW3 to the methionine and choline deficient (MCD) diet induced NAFLD rats could improve the liver impairments and reduce inflammation through TLR4-MyD88 and JNK signaling pathways. Moreover, ZW3 modulated gut microbiota by promoting relative abundance of Firmicutes and Lactobacillus, decreasing the abundance of Escherichia-Shigella and Bacteroides. Functional prediction of microbiome showed ZW3 presented potential enhancement on carbohydrate and lipid metabolism, cell process control and signal transduction processes, and reduced several human diseases.CONCLUSION: This present study identified a novel probiotic and its protective effects on NAFLD, and interpreted the interactions of ZW3 with the immune system and gut microbiota involved in gut-liver axis.

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Section: Resultssupporting

confidence: 89%

Section: Zw3 Alleviate Gut Microbiota Dysbiosis In Nafld Rat Induced ...mentioning

confidence: 97%

Identification of a novel probiotic and its protective effects on NAFLD via modulating gut microbial community

Geng

Yang

et al. 2022

J Sci Food Agric

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“…Corynebacterium is often considered an important opportunistic pathogen. Recent findings by Wang et al 22 suggest a strong relationship between Corynebacterium and the regulation of intestinal defense mechanisms in patients with ulcerative colitis. Similarly, Staphylococcus, an important pathogen associated with antibiotic resistance, has been reported in numerous cases of intestinal disease.…”

Section: Discussionmentioning

confidence: 99%

Successful allogeneic fecal microbiota transplantation for severe diversion colitis: a case report

Cheng,

Wang,

Fan

et al. 2024

J Int Med Res

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Ileostomy diverts the flow of feces, which can result in malnutrition in the distal part of the intestine. The diversity of the gut microbiota consequently decreases, ultimately leading to intestinal dysbiosis and dysfunction. This condition can readily result in diversion colitis (DC). Potential treatment strategies include interventions targeting the gut microbiota. In this case study, we effectively treated a patient with severe DC by ileostomy and allogeneic fecal microbiota transplantation (FMT). A 69-year-old man presented with a perforated malignant tumor in the descending colon and an iliac abscess. He underwent laparoscopic radical sigmoid colon tumor resection and prophylactic ileostomy. Follow-up colonoscopy 3 months postoperatively revealed diffuse intestinal mucosal congestion and edema along with granular inflammatory follicular hyperplasia, leading to a diagnosis of severe DC. After two rounds of allogeneic FMT, both the intestinal mucosal bleeding and edema significantly improved, as did the diversity of the gut microbiota. The positive outcome of allogeneic FMT in this case highlights the potential advantages that this procedure can offer patients with DC. However, few studies have focused on allogeneic FMT, and more in-depth research is needed to gain a better understanding.

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“…A recent study showed that NAFLD could be induced by altering the intestinal microbiome profile after cholecystectomy in the standard diet-fed and HF diet-fed groups ( 24 ). However, one study involving 32,428 human subjects reported that cholecystectomy may not be a risk factor for fatty liver disease ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between cholecystectomy and development of non-alcoholic liver disease in the mouse model

Kim¹,

Lee²,

Saeed³

et al. 2022

Ann Transl Med

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Background: Several clinical studies have suggested a strong correlation between cholecystectomy and the incidence of non-alcoholic fatty liver disease (NAFLD) although the exact correlation and causal relationship are unclear. This study aimed to investigate whether cholecystectomy increases the incidence of NAFLD or aggravates pre-existing NAFLD.Methods: Standard diet-fed and high-fat (HF) diet-fed mice were subjected to sham operation and cholecystectomy. In study 1, 20 standard diet-fed C57BL/6N mice were sacrificed at months 1, 2, and 4 post-surgery. Meanwhile, in study 2, 25 HF diet-induced NAFLD C57BL/6N mice were biopsied at months 2 and 3 post-surgery and sacrificed at month 6 post-surgery. The hepatic fatty acid and bile acid metabolic pathways and the hepatic bile composition were evaluated. Results:The bodyweight and biochemical parameters (hepatic enzyme, triglyceride, and cholesterol levels) were not significantly different between the standard diet-fed sham and cholecystectomy groups.The NAFLD activity score and the levels of hepatocyte apoptosis markers (Krt18 expression and DNA fragmentation) and de novo lipid synthesis genes were not significantly different between the standard dietfed sham and cholecystectomy groups. Cholecystectomy did not exacerbate hepatic steatosis, inflammation, and ballooning in the HF diet-fed mice. Hepatic bile acid composition was not markedly different in the sham and cholecystectomy groups fed on standard or HF diet. Cholecystectomy significantly downregulated Cyp7a1 and Cyp27a1 mRNA levels at months 1 and 4 post-surgery but did not affect the degree of steatosis and triglyceride levels. Analysis of bile acid metabolism revealed that taurine-conjugated bile acids were significantly downregulated in the standard diet-fed and high-fat diet-fed mice, but the histological and biochemical parameters were not markedly different.Conclusions: Cholecystectomy did not increase the incidence of NAFLD in standard diet-fed mice.Additionally, NAFLD incidence was not significantly different between the HF diet-fed sham and cholecystectomy groups. Furthermore, the histological parameters were not markedly different between the

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Dysbiosis of gut microbiota after cholecystectomy is associated with non‐alcoholic fatty liver disease in mice

Cited by 7 publications

References 42 publications

Identification of a novel probiotic and its protective effects on NAFLD via modulating gut microbial community

Identification of a novel probiotic and its protective effects on NAFLD via modulating gut microbial community

Successful allogeneic fecal microbiota transplantation for severe diversion colitis: a case report

Correlation between cholecystectomy and development of non-alcoholic liver disease in the mouse model

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