E-cadherin expression in basal cell carcinoma

Pizarro, Ángel; Benito, N; Navarro, Pilar; Palacios, José; Cano, Amparo; Quintanilla, Miguel; Contreras, Freddy; Gamallo, Carlos

doi:10.1038/bjc.1994.26

Cited by 62 publications

(49 citation statements)

References 37 publications

(40 reference statements)

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“…We have previously reported preserved E-CD expression in almost all tumour cells in cases of superficial and nodular BCC of skin (Pizarro et al, 1994). In the present series, we have observed that many cases of nodular BCC and some cases of superficial BCC had partially reduced E-CD expression, being composed of two populations of cells with different E-CD immunostaining.…”

Section: Mr-p P-and E-cadherin In Bccsupporting

confidence: 64%

“…Many factors seem to be implicated in the local aggressiveness and growth pattern of BCC, such as the integrity and composition of the basement membrane zone, the release of proteases implicated in the extracellular matrix degradation and the expression of cell-tosubstrate and cell-to-cell adhesion molecules, such as integrins and cadherins (Miller, 1991a;Stamp and Pignatelli, 1991;Pizarro et al, 1994).…”

Section: Mr-p P-and E-cadherin In Bccmentioning

confidence: 99%

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Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours

Pizarro

Gamallo²,

Benito³

et al. 1995

Br J Cancer

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Summary P-cadherin (P-CD) and E-cadherin (E-CD) are expressed by keratinocytes and play an important role in skin morphogenesis. P-CD expression is restricted to the basal layer of normal epidermis, whereas E-CD is expressed in all the living layers. We have previously reported a reduced expression of E-CD in most cases of infiltrative basal cell carcinoma (BCC). In the present work we have investigated by immunohistochemistry the expression of both P-CD and E-CD in a new series of 32 patients with BCC. Most cases of superficial multicentric BCC and some nodular tumours had preserved expression of both cadherins in all tumour cells. The majority of nodular BCCs had partially reduced expression of one or both cadherins with an ordered distribution of cells showing different cadherin staining throughout the tumour mass. A severe reduction of E-CD expression with a disordered distribution of cells with different immunostaining intensity was observed in most specimens of infiltrative BCC. In contrast, P-CD expression was preserved in all cases of infiltrative BCC. These results suggest that P-CD and E-CD play different roles in the growth pattern of BCC. In addition, both anomalous P-CD expression and reduced E-CD expression were frequently observed in the spinous layer of epidermis overlying tumours. This phenomenon was significantly associated with the presence of keratinocytic atypia, which suggests that disturbed cadherin expression could be a marker of premalignant changes and/or hyperproliferative activity in human epidermis.

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Section: Mr-p P-and E-cadherin In Bccsupporting

confidence: 64%

Section: Mr-p P-and E-cadherin In Bccmentioning

confidence: 99%

Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours

Pizarro

Gamallo²,

Benito³

et al. 1995

Br J Cancer

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“…This finding is surprising, as loss of E-cadherin is believed to be related to locally invasive and metastatic phenotypes and to poor prognosis in basal cell carcinoma; Pizarro et al 12 have suggested that E-cadherin may be regarded as an invasion-suppression molecule.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 In contrast, E-cadherin may serve to counteract the invasiveness of basal cell carcinoma. 12 The role of myosin, if any, has not been evaluated in basal cell carcinoma.…”

mentioning

confidence: 99%

Metastatic basal cell carcinoma exhibits reduced actin expression

et al. 2008

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Basal cell carcinoma is the most common malignancy in Caucasian individuals. Metastatic basal cell carcinoma is extremely rare (with a rate estimated as 0.03%). Actin has been detected in aggressive forms of basal cell carcinoma, but their expression in metastatic lesions is not known. We compared the expression of actin and actin-related cytoskeletal proteins in relatively less aggressive basal cell carcinoma (nodular), aggressive basal cell carcinoma (infiltrative/morpheaform), and metastatic basal cell carcinoma. We studied 12 cases of nodular basal cell carcinoma, 10 cases of infiltrative basal cell carcinoma, and 10 cases of metastatic basal cell carcinoma with immunohistochemistry for alpha-smooth muscle actin, calponin, myosin, and E-cadherin. Expression was interpreted as positive when at least 5% of the tumor exhibited at least weak expression. Five of the ten patients with metastatic basal cell carcinoma had an antecedent history of radiotherapy. Actin was present in 3 of 12 (25%) of the nodular, all 10 of the infiltrative, and 3 of 10 of the metastatic basal cell carcinomas (Po0.05 for metastatic vs infiltrative and nodular vs infiltrative). Calponin was present in 50% of the nodular, 60% of the infiltrative, and 30% of the metastatic basal cell carcinomas (not statistically significant). Myosin expression was not detected in any of the cases. E-cadherin was present in 75% of the nodular, 70% of the infiltrative, and all of the metastatic basal cell carcinomas (Po0.05 for metastatic vs nodular). Our results suggest that increased actin may contribute to local invasiveness, but it is lost in the metastatic phenotype. History of previous radiotherapy may contribute to development of the metastatic phenotype. Despite this high incidence, metastatic basal cell carcinoma is extremely rare, with most recent studies suggesting that the rate is approximately 0.03%.2 Many of the reported cases have involved recurrent tumors or aggressive histological subtypes. Nearly 85% of all metastasizing basal cell carcinomas involve the head and neck region.3 Metastatic spread is most often to the regional lymph nodes followed in descending order by the lungs, bones, and skin. 4 A review of 170 published cases of metastatic basal cell carcinoma showed a twofold male predilection, an average age of primary onset at 45 years, and a 9-year median interval to metastasis.5 Risk factors for metastatic basal cell carcinoma include persistent tumor for many years, previous radiation and large tumor size with a rate of 1.9% in tumors over 3 cm in diameter, nearly 50% for tumors over 10 cm in diameter, and 100% in tumors 4400 cm 2

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“…Disease states characterized by cellular dedifferentiation and/or hyperplastic cell growth, such as tumor or cyst formation, are frequently associated with altered levels of cadherin expression. For example, reduced levels of E-cadherin have been observed in carcinomas of the lung (Böhm et al, 1994), thyroid (Brabant et al, 1993), prostate (Umbas et al, 1992), skin (Pizarro et al, 1994), breast (Moll et al, 1993), colon (Dorudi et al, 1993), head and neck (Schipper et al, 1991), and bladder (Otto et al, 1994).…”

Section: Introductionmentioning

confidence: 95%