Effect of Underlying Comorbidities on the Infection and Severity of COVID-19 in Korea: a Nationwide Case-Control Study

Ji, Wonjun; Huh, Kyungmin; Kang, Minsun; Hong, Jinwook; Bae, Gi Hwan; Lee, Ye Rin; Na, Yewon; Choi, Hojong; Gong, Seon Yeong; Choi, Yoon-Hyeong; Ko, Kwang Pil; Im, Jeong Soo; Jung, Jaehun

doi:10.3346/jkms.2020.35.e237

Cited by 137 publications

(146 citation statements)

References 16 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…In this work, only 6.8% of RA patients reported the need for hospitalization mainly due to a flare of the disease or COVID-19 infection and most of those cases found difficulty to be admitted. RA patients with severe COVID-19 and who warranted hospitalization were significantly more likely to be older and have comorbid hypertension, chronic obstructive pulmonary disease, diabetes, renal failure and end-stage renal disease [ 30 , 31 ]. Data from the COVID-19 Global Rheumatology Alliance physician-reported registry including 600 rheumatic diseases cases from 40 countries revealed that 9% died and that 46% were hospitalized.…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 pandemic on rheumatoid arthritis from a Multi-Centre patient-reported questionnaire survey: influence of gender, rural–urban gap and north–south gradient

et al. 2020

View full text Add to dashboard Cite

During the coronavirus disease-2019 (COVID-19) pandemic there were several barriers to treatment access and medication adherence in rheumatoid arthritis (RA) patients. There is no information regarding the RA patient health status in Egypt during the COVID-19. Thus,the aim of this work was to study the impact of the pandemic on RA patients through a patient-reported questionnaire and to determine the influence of gender, geographic regions. This multi-centre study initiated by the Egyptian College of Rheumatology (ECR) was conducted on 1037 RA patients attending rheumatology clinics from 10 governorates. The questionnaire provided covered socio-demographic data, health/disease status, information/knowledge about COVID-19 and medical/family history of the infection. Patients mean age was 44.2 ± 12.3 years;855 females and 182 males; 539(52%) from rural and 497(48%) from urban areas. 41.8% reported a striking difficulty to obtain hydroxychloroquine during the pandemic. The majority (70%) considered maintaining a regular visit to the rheumatologist in addition to remote contact mainly by phone (44.4%) or via WhatsApp (33.1%), in particular among male and urban patients. Urban patients were more likely to be infected by COVID-19 (12.9% vs 6.2%; p < 0.0001) than rural. Northern cities had more patients with suspected COVID-19 (13.9% vs 6.1%; p < 0.0001); was significantly associated with more disease flares (30.8% vs 5.8%) with subsequent change in the RA treatment (20.9% vs 6.4%; p < 0.0001). Patients with RA faced remarkable difficulty to obtain their medications with subsequent change in their disease status. The challenges of the pandemic have hastened changes in the way we deliver health care. Electronic supplementary material The online version of this article (10.1007/s00296-020-04736-9) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 pandemic on rheumatoid arthritis from a Multi-Centre patient-reported questionnaire survey: influence of gender, rural–urban gap and north–south gradient

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Comorbid conditions such as diabetes mellitus, respiratory, cardiovascular and renal illnesses, and obesity, and an older age group are known to be positively associated with poor outcomes among COVID-19 patients [10][11][12][13]. Furthermore, research studies have demonstrated that COVID-19 patients with diabetes have poorer clinical prognoses, are at higher risks of complications, such as respiratory failure and acute cardiac injury, and have shorter overall survival times than their non-diabetic counterparts [14].…”

Section: Introductionmentioning

confidence: 99%

“…Several systematic reviews and meta-analyses [15,16], cohort [14,17], case-control [12], and cross-sectional studies [16,18] have demonstrated that diabetic patients with COVID-19 are at considerably greater risk of mortality and of developing more severe disease than COVID-19 patients without diabetes. However, it was reported in a recent study that diabetes had no effect on the prognosis of COVID-19 patients but was negatively associated with clinical outcomes [19], which indicated studies are needed to narrow gaps in our understanding of the disease, and thus, aid decision-making by health care providers and administrators.…”

Section: Introductionmentioning

confidence: 99%

Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes

Acharya

Lee

et al. 2020

Healthcare

View full text Add to dashboard Cite

Studies have confirmed COVID-19 patients with diabetes are at higher risk of mortality than their non-diabetic counterparts. However, data-driven evidence of factors associated with increased mortality risk among hospitalized COVID-19 patients with diabetes is scarce in South Korea. This study was conducted to determine the mortality rate and identify risk factors of mortality among hospitalized COVID-19 patients with type 2 diabetes in Gyeongsangbuk-do province, South Korea. In this hospital-based, cross-sectional study, we enrolled a total of 324 patients with confirmed COVID-19, hospitalized at two of the tertiary level healthcare facilitates of Gyeongsangbuk-do, South Korea from 18 February to 30 June 2020. Demographic and clinical data and laboratory profiles were analyzed and multivariate logistic regression analysis was used to identify risk factors of mortality among diabetic patients with COVID-19. Of the 324 patients, 55 (16.97%) had diabetes mellitus. The mean age of all study subjects was 55 years, and the mean age of those with diabetes was greater than that of those without (69.8 years vs. 51.9 years). Remarkably, the mortality rate was much higher among those with diabetes (20.0% vs. 4.8%). Multivariate logistic regression analysis revealed that an older age (≥70 years) and a high serum lactate dehydrogenase (LDH) levels significantly predicted mortality among hospitalized COVID-19 patients with diabetes. Our study cautions more attention to be paid to patients with diabetes mellitus hospitalized for COVID-19, especially those aged ≥ 70 years and those with a high serum LDH level, to reduce the risk of mortality.

show abstract

“…Dementia patients are especially vulnerable to COVID-19 infection due to their disease state, age, 37 and comorbid diseases. 38 Furthermore, COVID-19 positive dementia patients may manifest their neurological complications as behavioral and neuropsychological problems.…”

Section: Impact Of Covid-19 On Patients With Cognitive Impairmentmentioning

confidence: 99%

Coping with Dementia in the Middle of the COVID-19 Pandemic

et al. 2020

View full text Add to dashboard Cite

Multiple neurological complications have been associated with the coronavirus disease-19 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. This is a narrative review to gather information on all aspects of COVID-19 in elderly patients with cognitive impairment. First, the following three mechanisms have been proposed to underlie the neurological complications associated with COVID-19: 1) direct invasion, 2) immune and inflammatory reaction, and 3) hypoxic brain damage by COVID-19. Next, because the elderly dementia patient population is particularly vulnerable to COVID-19, we discussed risk factors and difficulties associated with cognitive disorders in this vulnerable population. We also reviewed the effects of the patient living environment in COVID-19 cases that required intensive care unit (ICU) care. Furthermore, we analyzed the impact of stringent social restrictions and COVID-19 pandemic-mediated policies on dementia patients and care providers. Finally, we provided the following strategies for working with elderly dementia patients: general preventive methods; dementia care at home and nursing facilities according to the activities of daily living and dementia characteristics; ICU care after COVID-19 infection; and public health care system and government response. We propose that longitudinal follow-up studies are needed to fully examine COVID-19 associated neurological complications, such as dementia, and the efficacy of telemedicine/telehealth care programs.

show abstract

Effect of Underlying Comorbidities on the Infection and Severity of COVID-19 in Korea: a Nationwide Case-Control Study

Cited by 137 publications

References 16 publications

Impact of COVID-19 pandemic on rheumatoid arthritis from a Multi-Centre patient-reported questionnaire survey: influence of gender, rural–urban gap and north–south gradient

Impact of COVID-19 pandemic on rheumatoid arthritis from a Multi-Centre patient-reported questionnaire survey: influence of gender, rural–urban gap and north–south gradient

Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes

Coping with Dementia in the Middle of the COVID-19 Pandemic

Contact Info

Product

Resources

About