Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Combs, Terry P.; Berg, Anders H.; Obici, Silvana; Scherer, Philipp E.; Rossetti, Luciano

doi:10.1172/jci14120

Cited by 807 publications

(564 citation statements)

References 47 publications

(20 reference statements)

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“…In the present study, adiponectin increased glucose uptake, but reduced the basal and insulin-stimulated rates of glycogen synthesis in muscle cells. Given that a previous study reported that full-length adiponectin had no effect on whole-body glucose uptake or glycogen synthesis [29], this indicates that gAd specifically mediates these processes via AdipoR1 in skeletal muscle. The observed reduction in glycogen synthesis was accompanied by a proportional increase in lactate production.…”

Section: Discussionmentioning

confidence: 80%

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

et al. 2004

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Section: Discussionmentioning

confidence: 80%

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

et al. 2004

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“…27 It also reduces hepatic glucose production. 28 AMPK has been confirmed to be a major downstream component of adiponectin signaling. 10 These published data are consistent with our earlier observations that BJ stimulated AMPK in muscle cells and adipocytes.…”

Section: Discussionmentioning

confidence: 99%

Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy mice

et al. 2009

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Aim: Biotransformation of blueberry juice by the Serratia vaccinii bacterium gave rise to adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and glucose uptake in muscle cells and adipocytes, but inhibited adipogenesis. This study investigated the antiobesity and antidiabetic potential of biotransformed blueberry juice (BJ) in KKA y mice, rodent model of leptin resistance. Methods: BJ was incorporated in drinking water of KKA y mice. Parameters of body weight, food intake, plasma glucose, insulin, leptin, and adiponectin were measured. Before and after therapy, animals were subjected to an oral glucose tolerance test. At the end of treatment, liver, muscle, kidney, epididymal fat pad, abdominal fat pad, and dorsal fat pad were collected and weighed. Results: Incorporating BJ in drinking water protected young KKA y mice from hyperphagia and significantly reduced their weight gain. Moreover, BJ protected young KKA y mice against the development of glucose intolerance and diabetes mellitus. Chronic BJ administration in obese and diabetic KKA y mice reduced food intake and body weight. This effect could not fully explain the associated antidiabetic effect because BJ-treated mice still showed lower blood glucose level when compared with pair-fed controls. The adipokines pathway also seems to be involved because BJ significantly increased adiponectin levels in obese mice. Conclusions: This study shows that BJ decreases hyperglycemia in diabetic mice, at least in part by reversing adiponectin levels. BJ also protects young pre-diabetic mice from developing obesity and diabetes. Thus, BJ may represent a novel complementary therapy and a source of novel therapeutic agents against diabetes mellitus.

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“…Differences statistically significant compared to non-pregnant with p<0.001 ISI Insulin sensitivity index, HGP hepatic glucose production a Pregnant vs pregravid tion of plasma adiponectin. Total adiponectin, as well as HMW multimers, decrease in response to insulin infusion [6,35,36], but this may be regulated at the level of secretion rather than transcription [37]. Adiponectin is secreted as HMW and LMW multimeric complexes, and the amount of circulating complexes is likely to be regulated at the tissue level because LMW and HMW complexes do not interchange in the serum [38].…”

Section: Regulation Of Adiponectin Expressionmentioning

confidence: 99%

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism

et al. 2006

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Aims/hypothesis: Adiponectin is upregulated during adipogenesis and downregulated in insulin-resistant states. The mechanism(s) governing the re-arrangements from adipogenesis to facilitated lipolysis during pregnancy are unknown. Our purpose was to analyse the role of adiponectin relative to the metabolic changes in human pregnancy. Subjects, materials and methods: Lean women (BMI <25 kg/m²) were evaluated longitudinally before conception, and in early (12-14 weeks) and late (34-36 weeks) pregnancy. Insulin sensitivity was measured using the glucose clamp technique. Venous blood and subcutaneous adipose tissue biopsies were obtained at each time point. Results: Adiponectin concentrations were lower in the third trimester than in the pregravid condition (9.9±1.4 vs 13.5±1.8 μg/ml). The hypoadiponectinaemia was reflected by a 2.5-fold decrease in white adipose tissue adiponectin mRNA. These changes were associated with a 25% increase in fat mass (23.7±2.9 vs 18.9±2.9 kg). Insulin infusion decreased high molecular weight adiponectin complexes in pregravid women (9.9±0.6 vs 6.2±0.06) and the suppressive effect of insulin was lost during pregnancy. The pregnancy-mediated changes in adiponectin were strongly correlated with basal insulin levels and insulin sensitivity (p<0.0001). The relationship between adiponectin and insulin sensitivity was related to the decreased insulin regulation of glucose utilisation (r=0.55, p<0.001) but not of endogenous hepatic glucose production. Conclusions/interpretation: These data demonstrate that pregnancy is associated with adiponectin changes in lean women. Hypoadiponectinaemia is reflected by a lower amount of high molecular weight adiponectin and by the ratio of high to low molecular weight multimers. The adiponectin changes relate to decreased insulin sensitivity of glucose disposal rather than alterations of lipid metabolism.

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Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Cited by 807 publications

References 47 publications

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy mice

Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism

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