Establishment of the milk-borne transmission as a key factor for the peculiar endemicity of human T-lymphotropic virus type 1 (HTLV-1): the ATL Prevention Program Nagasaki

Hino, Shinjiro

doi:10.2183/pjab.87.152

Cited by 130 publications

(162 citation statements)

References 24 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…We observed a smaller proportion of transmission among the children whose mothers were advised not to breastfeed and to give the infant formula instead, as previously reported in literature, especially in Japan [9]. Although our numbers were not large, there was a predominance of females, which coincides with prior reports [16].…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

Ms¹,

Cf²,

G³

et al. 2014

Trop Med Surg

View full text Add to dashboard Cite

Objective: Although HTLV-1 is associated with severe diseases, there is ongoing vertical transmission since prenatal HTLV screening is not implemented in countries where the virus is present. We performed a cross-sectional analysis to verify the impact of counseling pregnant HTLV-1 seropositive women, who participate in the GIPH cohort study in Brazil, on this vertical transmission.Methods: GIPH study started in 1997 as an open prevalent cohort of HTLV-positive individuals. Children born from HTLV-1 seropositive women were divided into: (1) born before and (2) after the participation of mothers in the GIPH cohort ("GIPH babies"). The pregnant women participating in the study were counseled in order to prevent viral transmission, with recommendations of avoiding breastfeeding, giving infant formula, and preferably having the delivery by cesarean section. Results:We identified 54 children born of HTLV seropositive mothers. 3/21 (14.3%) of the children born from mothers who received no counseling were found positive for HTLV-1, in contrast to 1/18 (5.6%) of the "GIPH babies", whose mothers received counseling. 15 children were not tested, either due to the family's refusal or impossibility to locate them. Discussion:We found that it was worthwhile to counsel the mothers, since, as previously reported in the literature, we could observe a decline in the vertical transmission, which demonstrates the importance of prenatal screening of the virus. These actions should be widespread in countries where HTLV is present, in order to avoid the silent transmission of HTLV and future diseases in children born from positive mothers.

show abstract

Section: Discussionsupporting

confidence: 89%

“…The postnatal mother to child infection occurs through breastfeeding [9]. Breastfeeding is generally regarded as a risk factor for HTLV infection in exposure periods longer than 6 months, which increases with high maternal proviral loads [10,11].…”

Section: Introductionmentioning

confidence: 99%

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

Ms¹,

Cf²,

G³

et al. 2014

Trop Med Surg

View full text Add to dashboard Cite

show abstract

“…The limited passage of infected lymphocytes through the placenta most likely contributes to the relative rarity of transplacental HTLV-1 infection 29,30 ; however, this type of HTLV-1 infection requires further study to evaluate its effects on the fetus, which could have implications for counseling serologically discordant couples who wish to have children. HTLV-1 transmission occurs through the transfusion of cellular blood components, which results in seroconversion in more than 40% of recipients; the transfusion of plasma or plasma derivatives does not result in seroconversion 31 .…”

Section: Modes Of Htlv Transmissionmentioning

confidence: 99%

“…Several years after the commencement of the ATL Prevention Program Nagasaki in 1987, a sharp decline in the prevalence of HTLV carriers (from 20%-25% to 4%) was observed in the Nagasaki population 30 .…”

Section: A Decrease In Htlv-1 Viral Shedding and A Reduction In Spreamentioning

confidence: 99%

Sexual transmission of human T-cell lymphotropic virus type 1

Paiva

Casseb

2014

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in many parts of the world and is primarily transmitted through sexual intercourse or from mother to child. Sexual transmission occurs more effi ciently from men to women than women to men and might be enhanced by sexually transmitted diseases that cause ulcers and result in mucosal ruptures, such as syphilis, herpes simplex type 2 (HSV-2), and chancroid. Other sexually transmitted diseases might result in the recruitment of infl ammatory cells and could increase the risk of HTLV-1 acquisition and transmission. Additionally, factors that are associated with higher transmission risks include the presence of antibodies against the viral oncoprotein Tax (anti-Tax), a higher proviral load in peripheral blood lymphocytes, and increased cervicovaginal or seminal secretions. Seminal fl uid has been reported to increase HTLV replication and transmission, whereas male circumcision and neutralizing antibodies might have a protective effect. Recently, free virions were discovered in plasma, which reveals a possible new mode of HTLV replication. It is unclear how this discovery might affect the routes of HTLV transmission, particularly sexual transmission, because HTLV transmission rates are signifi cantly higher from men to women than women to men.

show abstract

“…At one time, Japan had high rates of MTCT, ranging from 15 to 25% [11]. However, through the systematic serological screening of pregnant women and by avoiding breastfeeding, the MTCT rate recently decreased to approximately 3% [11][12][13]. Thus, one action which prevents transmission is not breastfeeding.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Decisions among People Living with Human T-cell Lymphotropic Virus Type 1 (HTLV-1)

Alvarenga¹

2013

J Infect Dis Ther

View full text Add to dashboard Cite

Background: Human T-cell Lymphotropic Virus type 1 (HTLV-1) infection is a neglected public health problem. The majority of carriers is asymptomatic and may have a low risk of developing related diseases. The aims of this study were to discuss reproductive decisions of women and men living with HTLV-1 infection to assess their perception of infection and associated diseases, expectations regarding Mother-to-Child Transmission (MTCT), and whether health care conditions may affect their reproductive decisions.

show abstract

Establishment of the milk-borne transmission as a key factor for the peculiar endemicity of human T-lymphotropic virus type 1 (HTLV-1): the ATL Prevention Program Nagasaki

Cited by 130 publications

References 24 publications

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

Sexual transmission of human T-cell lymphotropic virus type 1

Reproductive Decisions among People Living with Human T-cell Lymphotropic Virus Type 1 (HTLV-1)

Contact Info

Product

Resources

About