Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/MS method

Mata-Granados, J.M.; Vargas-Vasserot, J.; Ferreiro‐Vera, Carlos; Castro, M.D. Luque de; Pavón, R. Guerrero; Gómez, José Manuel

doi:10.1016/j.jsbmb.2010.03.078

Cited by 91 publications

(68 citation statements)

References 23 publications

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“…The Spanish MataGranados Group demonstrated that 60.000 IU cholecalciferol administered orally at day 0 and day 4 evoked a significant rise in 25(OH)D3 and 1.25. di-(OH)D3 levels whereas the application of 2ug calcitriol intravenously on alternate days had no impact on these levels in septic patients [28].…”

Section: Vitamin D Supplementationmentioning

confidence: 89%

“…There were large individual differences in 25(OH)D3 levels probably due to large variations in gastrointestinal absorption [51]. Intravenous formulations could overcome this problem but i.v administration of calcitriol had no impact on 25(OH)D3 and 1.25 di-(OH)D3 levels in septic patients as shown in the Mata-Granados study [28].…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

“…Calcitriol levels correlated positively with 25(OH) D3 in this setting. This suggests substrate deficiency may be more profound in critically ill patients [20,[25][26][27][28]. Therefore vitamin D deficiency in the ICU is a mismatch between substrate supply and tissue requirements.…”

Section: Vitamin D and Metabolitesmentioning

confidence: 99%

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Hypocalcemia in the Critically Ill: A Mini-Review

Naafs¹

2017

EMIJ

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In this mini-review of hypocalcemia in the critically ill patient historical and new insights in the function of the PTH-vitamin D axis are discussed Special attention is given to the role of locally tissue produced calcitriol in the immune system and in the inflammatory cytokine response of the vitamin D deficiënt critically ill patient.Future directions in this research area and in the forthcoming research on the use of the anabolic recombinant PTH analogues in critical care medicine are discussed.

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Section: Vitamin D Supplementationmentioning

confidence: 89%

Section: Vitamin D Supplementationmentioning

confidence: 99%

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Hypocalcemia in the Critically Ill: A Mini-Review

Naafs¹

2017

EMIJ

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“…In the study conducted by van der Berghe et al [36], intravenous supplementation of vitamin D in patients hospitalized in ICUs for a long time did not lead to increased serum concentrations of vitamin D or resulted in its increase, which did not affect the patient's condition. According to one study, the vitamin D supplementation had beneficial effects on critically ill patients [37].…”

Section: Significance Of Vitamin D In Icu Patientsmentioning

confidence: 99%

Vitamin D in critically ill patients

Matysiak-Luśnia

2016

Anaesthesiol Intensive Ther

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Vitamin D deficiency is a commonly observed global phenomenon, both in the general population and in hospitalized patients, including critically ill patients. Vitamin D deficiency is associated with multiple adverse health outcomes, including increased morbidity and mortality in the general population and in critically ill patients. Vitamin D is a fatsoluble vitamin that plays an important role in bone metabolism. However, Vitamin D is also a steroid hormone that exerts multiple pleiotropic effects. Vitamin D regulates immunity, inflammation, cell proliferation, differentiation, apoptosis, and angiogenesis. There is growing evidence of a close relationship between vitamin D insufficiency and various systemic disorders, i.e., type II diabetes, certain types of cancer, obesity, and cardiovascular morbidities. The purpose of this article is to present the current knowledge on the relationship between vitamin D status and critical illness. Key words: vitamin D, critical illness, intensive care, critically illAnaesthesiology Intensive Therapy 2016, vol. 48, no 3, 201-207 There is mounting evidence of the role of vitamin D in blood serum as a factor determining the course and prognosis of numerous diseases. Knowledge of the molecular basis of vitamin D action, its extraosseous effects and its significant role in the prevention and treatment of chronic diseases, especially inflammatory diseases, is growing. This paper presents the current state of knowledge regarding vitamin D, particularly its role in critically ill patients treated in intensive care units (ICUs). PRODUCTION AND METABOLISM OF VITAMIN DVitamin D belongs to the group of steroid chemical compounds with the general formula C 28 H 43 OH. The group contains vitamin D1 (a mixture of cholecalciferol and lumisterol occurring in cod liver oil, a compound with a similar structure as vitamin D but without the same activity), vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D2 occurs in plants, whereas vitamin D3 is produced in human and animal skin, mainly in the keratocytes of the proliferative epithelium, mediated by ultraviolet radiation (specifically UVB radiation). The compounds are activated in the liver by hydroxylation to 25-hydroxyderivatives and subsequently in other organs to 1,25-dihydroxyderivatives. The latter conversion occurs primarily in the kidneys and is mediated by parathormone (PTH). Calcitriol (1,25-dihydroxycholecalciferol) is an active form of vitamin D3, a substance of hormonal action regulating many organs and tissues. Although the metabolic effects of vitamin D2 and vitamin D3 are similar, they bind with different types of plasma proteins. As a result, the action of vitamin D3 is longer and 2-10-fold more effective than vitamin D2.Vitamin D3 is one of a few vitamins that the body is able to produce endogenously; therefore, it does not fulfil the definition of a vitamin. Ultraviolet radiation is required for the production of Vitamin D3 in the body, more specifically UVB (wavelength of 280−315 nm), which e...

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“…115 Studies of vitamin D replacement studies in the critically ill have mainly considered short-term outcomes and have generally led to increases in vitamin D levels. 116,117 Whether the latter translates into meaningful clinical outcomes remain to be seen. supplementation as a pharmaconutrient in critically ill patients has been described, 118 but clinical intervention trials studying vitamin B 12 as a pharmaconutrient strategy in the critical care setting are awaited.…”

Section: Cccpg Aspen/sccm Espenmentioning

confidence: 99%