Factors associated with parietal cell autoantibodies in the general population

León, Antonio Cabrera de; González, Delia Almeida; Almeida, Ana Arencibia; Hernández, Ana González; Pérez, Mercedes Carretero; Pérez, María del Cristo Rodríguez; Guillén, Vicente Gil; Díaz, Buenaventura Brito

doi:10.1016/j.imlet.2012.06.004

Cited by 31 publications

(22 citation statements)

References 33 publications

(34 reference statements)

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“…It is worth noting that APCA+IPF patients were mainly men smokers, as was the control APCA-population. In one study conducted in the general population, smoking acted as protective factor against the appearance of APCA, whereas female sex was associated with an increased risk [37]. This observation is in contradiction with what we observed in our IPF population.…”

Section: Discussioncontrasting

confidence: 99%

Anti-parietal cell autoimmunity is associated with an accelerated decline of lung function in IPF patients

Beltramo

Thabut

Péron

et al. 2018

Respiratory Medicine

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Section: Discussioncontrasting

confidence: 99%

Anti-parietal cell autoimmunity is associated with an accelerated decline of lung function in IPF patients

Beltramo

Thabut

Péron

et al. 2018

Respiratory Medicine

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“…Gender differences are probably caused by the prevalence of different types of autoimmune gastritis (AIG), and the prevalence of AIG in women was higher compared to men [38]. Parietal cell antibodies, which are thought to be pathogenetic antibodies of AIG, were found more frequently in women than in men (OR 2.4; 95% CI 1.1–5.3) [39]. Some women patients with AIG were possibly enrolled in our study.…”

Section: Discussionmentioning

confidence: 99%

Hypergastrinemia in Long-Term Use of Proton Pump Inhibitors

Shiotani¹,

Katsumata²,

Gouda³

et al. 2018

Digestion

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Background/Aim: The use of proton pump inhibitors (PPIs) is known to lead to hypergastrinemia; however, the data in patients with atrophic gastritis is still lacking. The aim of this study was to investigate the effects of long-term PPIs use on the gastrin levels in patients with atrophic gastritis and to determine factors affecting hypergastrinemia in long-term users of PPIs. Methods: Serum Helicobacter pylori IgG, gastrin and pepsinogen levels were measured. Atrophic gastritis was assessed by upper gastrointestinal endoscopies based on the Kimura-Takemoto classification and pepsinogen levels. CYP2C19 polymorphisms were assessed using DNA extracted from peripheral blood. Results: A total number of 382 patients (275 men and 107 women) were enrolled. Median serum gastrin levels were higher in PPI users than in non- users (234 vs. 113 pg/mL, p < 0.001) and in women than in men (252 vs. 155 pg/mL, p = 0.006). Gastrin levels were significantly associated with corpus atrophy only in the subgroup of non-users of PPIs. Multivariate analysis revealed that hypergastrinemia (over 150 pg/mL) was significantly associated with PPI use (OR 5.30; 95% CI 3.32–8.47), women (OR 2.22; 95% CI 1.33–3.72) and corpus atrophy (OR 1.82; 95% CI 1.14–2.90). Conclusion: PPI use, women and corpus atrophy were risk factors for hypergastrinemia. Gender, but not corpus atrophy, affected the gastrin levels in long-term users of PPIs.

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“…PCA is a biomarker of autoimmune gastritis 26 and requires a serum titer greater than the upper limit of the normal reference range for diagnosis. T1DM primarily occurs as a result of autoimmune-mediated pancreatic β-cell destruction.…”

Section: Discussionmentioning

confidence: 99%

Type 1 Diabetic Populations Have an Increased Prevalence of Parietal Cell Antibody

Pan

Shan

2015

Medicine

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The presence of parietal cell antibody (PCA) in serum is a biomarker of autoimmune gastritis. PCA directly recognizes the H+/K+ ATPase expressed in parietal cells, which is responsible for the active transport of hydrogen ions in exchange for potassium ions to increase the acidity of gastric secretions. Type 1 diabetes mellitus (T1DM) mainly results from pancreatic β-cell destruction due to cell-type specific autoimmunity. Considering autoimmune factors may be the common characteristics of both PCA positivity and T1DM, it is likely that both disorders may coexist within the same patient. The main objective of this meta-analysis is to provide a reliable evaluation to clarify the association between PCA positivity and T1DM by combining the raw data from all of the relevant studies.Literature databases, including the Medline, Embase, and Web of Science, were systematically queried for studies investigating the association between PCA positivity and T1DM and were published from January 1980 to December 2014. A total of 3,584 T1DM cases and 2,650 non-T1DM controls were included in this meta-analysis, which showed that PCA positivity was more prevalent in patients with T1DM than healthy controls. Publication bias testing found no significant biases and sensitivity analysis demonstrated that our statistics were relatively stable and credible.Our findings suggested that T1DM was associated with an increased risk of PCA positivity compared to control populations.

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Factors associated with parietal cell autoantibodies in the general population

Cited by 31 publications

References 33 publications

Anti-parietal cell autoimmunity is associated with an accelerated decline of lung function in IPF patients

Anti-parietal cell autoimmunity is associated with an accelerated decline of lung function in IPF patients

Hypergastrinemia in Long-Term Use of Proton Pump Inhibitors

Type 1 Diabetic Populations Have an Increased Prevalence of Parietal Cell Antibody

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