Fat grafting in aesthetics

Dayal, Arjun; Bhatia, Ashish C.; Hsu, Jeffrey T.S.

doi:10.1016/j.clindermatol.2021.08.010

Cited by 5 publications

(2 citation statements)

References 75 publications

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“…However, these same cells harbor a theoretical risk in their potential to impact the recurrence of a breast cancer, given they are multipotent stem cells. Consequently, there has been significant controversy over the long-term safety profile of AFG in women undergoing reconstruction for breast cancer 29,30 . Although there has been some prior work done evaluating the use of AFG after mastectomy, to date, there remains a lack of consensus regarding this topic in the setting of breast-conserving therapies, such as lumpectomies.…”

Section: Discussionmentioning

confidence: 99%

Oncologic Safety in Autologous Fat Grafting After Breast Conservation Therapy

et al. 2023

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Background Autologous fat grafting (AFG) is often used to reconstruct defects after breast conservation therapy (BCT). However, concerns exist about the possibility of AFG-related recurrence or metastasis. This study aims to evaluate the literature to evaluate oncologic outcomes in patients undergoing AFG at the time of BCT. Methods A systematic review of articles related to AFG based reconstruction at the time of BCT from 1970 to 2021 was performed via PubMed. Patients were grouped based on the presence or lack of AFG usage at the time of BCT, and oncologic outcomes and complications were compared. Results Of the 146 articles identified, 15 were included. Nine hundred patients underwent BCT alone and 1063 patients underwent BCT with AFG patients. Similar average follow-up time was observed between the groups, 58.7 months (BCT only) and 55.2 months (BCT with AFG). On pooled analysis, no difference was identified in local recurrence 4.8% (43 patients) of the BCT group and 3% (32 patients) in the AFG group (P = 0.8), metastasis 4.8% (43 patients) of the BCT group and 6.9% (73 patients) in the AFG group (P = 0.3), or fat necrosis (P = 0.44). Meta-analysis additionally did not identify any statistically significant odds ratios between the BCT only group and BCT with AFG group when evaluated for total recurrence, local recurrence, metastasis or fat necrosis. Conclusions The results show no significant difference in cancer recurrence or metastasis in the BCT only group versus BCT and AFG, showing that fat grafting has safe outcomes.

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Section: Discussionmentioning

confidence: 99%

Oncologic Safety in Autologous Fat Grafting After Breast Conservation Therapy

et al. 2023

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“…In our clinical practice, fat grafting is frequently used in patients with staged breast reconstruction, especially in the correction of contour deformities, scars, and asymmetries after reconstruction. Studies have shown that the average graft volume reduction ranges from 25% to 70% of the total implanted volume, and additional interventions are needed 2 . Therefore, in our clinical practice, we apply 2 or 3 sessions of fat grafting in patients undergoing breast reconstruction.…”

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confidence: 99%