Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome

Cooke, Aoife A.; Connaughton, Ruth M.; Lyons, Claire L.; McMorrow, Aoibheann M; Roche, Helen M.

doi:10.1016/j.ejphar.2016.04.021

Cited by 104 publications

(79 citation statements)

References 92 publications

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“…Author details 1 Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia.…”

Section: Consent For Publicationmentioning

confidence: 99%

“…The role of inflammation in the aetiology and pathogenesis of arterial hypertension is not so obvious upon first blush, but the significance of low-grade chronic inflammation in the development of metabolic syndrome, atherosclerosis, and obesity has been established in many studies [1][2][3][4][5][6]. It is known that the processes of coagulation and anticoagulation, the fibrinolytic system, and thrombocytes are integral to asthma pathophysiology [7].…”

Section: Introductionmentioning

confidence: 99%

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Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

et al. 2018

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Background: Hypertension and bronchial asthma are a major issue for people's health. As of 2014, approximately one billion adults, or~22% of the world population, have had hypertension. As of 2011, 235-330 million people globally have been affected by asthma and approximately 250,000-345,000 people have died each year from the disease. The development of the effective treatment therapies against these diseases is complicated by their comorbidity features. This is often a major problem in diagnosis and their treatment. Hence, in this study the bioinformatical methodology for the analysis of the comorbidity of these two diseases have been developed. As such, the search for candidate genes related to the comorbid conditions of asthma and hypertension can help in elucidating the molecular mechanisms underlying the comorbid condition of these two diseases, and can also be useful for genotyping and identifying new drug targets. Results: Using ANDSystem, the reconstruction and analysis of gene networks associated with asthma and hypertension was carried out. The gene network of asthma included 755 genes/proteins and 62,603 interactions, while the gene network of hypertension -713 genes/proteins and 45,479 interactions. Two hundred and five genes/proteins and 9638 interactions were shared between asthma and hypertension. An approach for ranking genes implicated in the comorbid condition of two diseases was proposed. The approach is based on nine criteria for ranking genes by their importance, including standard methods of gene prioritization (Endeavor, ToppGene) as well as original criteria that take into account the characteristics of an associative gene network and the presence of known polymorphisms in the analysed genes. According to the proposed approach, the genes IL10, TLR4, and CAT had the highest priority in the development of comorbidity of these two diseases. Additionally, it was revealed that the list of top genes is enriched with apoptotic genes and genes involved in biological processes related to the functioning of central nervous system.

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“…Author details 1 Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia.…”

Section: Consent For Publicationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

et al. 2018

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“…29,30 However an imbalance in lipid and fatty acid intake has been linked to adverse health effects such as increased risk of diseases for example CVD, diabetes and MetS. 31,32 For such reasons there is a need to identify robust validated biomarkers of total dietary fat intake, which at present is lacking. 33 In our study we focused on a panel of 22 lipid metabolites that had strong positive correlations with both total dietary fat intake and SFA intake.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach

et al. 2017

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The UCD community has made this article openly available. Please share how this access benefits you. Your story matters! (@ucd_oa) Some rights reserved. For more information, please see the item record link above. AbstractEpidemiology and clinical studies provide clear evidence of the complex links between diet and health. To understand these links, reliable dietary assessment methods are pivotal. Biomarkers have emerged as more objective measures of intake compared to traditional dietary assessment methods. However, there are only a limited number of putative biomarkers of intake successfully identified and validated. The use of biomarkers that reflect food intake to examine diet related diseases represents the next step in biomarker research. Therefore, the aim of this study was to (1) identify and confirm biomarkers associated with dietary fat intake and (2) examine the relationship between those biomarkers with health parameters. Heatmap analysis identified a panel of 22 lipid biomarkers associated with total dietary fat intake in the Metabolic Challenge (MECHE) Study.

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“…The impairment of lipid metabolism leads to excessive lipid accumulation and triggers inflammatory responses. Some studies have shown that inflammation is involved in many metabolic diseases, including diabetes, hypertension, and NAFLD [10,11] . Inflammation disturbs cellular metabolism and function via the endoplasmic reticulum (ER) stress or oxidative stress, which induces metabolic diseases by interfering with normal glucose and lipid metabolism [12,13] .…”

Section: The Role Of Lipid Metabolism With Inflammation In Non-alcohomentioning

confidence: 99%

The Regulation of Lipid Metabolism by Targeting Opioid Receptors in Nonalcoholic Fatty Liver Disease

Chung

2017

Journal of Gastroenterology and Hepatology Research

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Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome

Cited by 104 publications

References 92 publications

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks

Exploring the Links between Diet and Health in an Irish Cohort: A Lipidomic Approach

The Regulation of Lipid Metabolism by Targeting Opioid Receptors in Nonalcoholic Fatty Liver Disease

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