Functional co-activation within the prefrontal cortex supports the maintenance of behavioural performance in fear-relevant situations before an iTBS modulated virtual reality challenge in participants with spider phobia

Deppermann, Saskia; Notzon, Swantje; Kroczek, Agnes; Rosenbaum, David; Haeußinger, Florian B.; Diemer, Julia; Domschke, Katharina; Fallgatter, Andreas J.; Ehlis, Ann‐Christine; Zwanzger, Peter

doi:10.1016/j.bbr.2016.03.028

Cited by 36 publications

(36 citation statements)

References 55 publications

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“…The article mainly studies: Stroke rehabilitation (i) [ 25 ] [ 30 ] The effects of NIBS, VR and its combination on therapy for upper limb training in patients with subacute stroke. The effects of combining NIBS with VR-based motor skill training in patients with subacute stroke (ii) [ 31 ] The effect of adding NIBS to VR therapy, for upper limb training in unilateral stroke [ 29 ] Whether combining NIBS with VR training could improve upper limb function in subacute stroke patients [ 28 ] The effects of adding NIBS to a VR-BCI therapy for motor recovery after stroke [ 32 ] The effects of adding NIBS in VR therapy to improve upper limb motor function after stroke (iii) [ 33 ] The effects of NIBS-VR paradigm for upper limb rehabilitation in a stroke survivor with severe hemiparesis Phobia and PTSD (ii) [ 34 ] [ 35 ] The effects on acute anxiety of adding NIBS to a VR experience for patients with spider phobia The impact on emotion regulation of adding NIBS to a VR experience for patients with spider phobia [ 36 ] The use of NIBS during VR experience to reduce psychophysiological arousal and symptoms in veterans with PTSD Cerebral palsy (ii) [ 37 ] The effects of a single session of NIBS combined with VR training on functional mobility in children with cerebral palsy [ 26 ] The effects of a single session of NIBS combined with VR training on the balance of children with cerebral palsy [ 38 ] ...…”

Section: Resultsmentioning

confidence: 99%

Virtual reality and non-invasive brain stimulation for rehabilitation applications: a systematic review

Cassani

Novak

Falk

et al. 2020

J NeuroEngineering Rehabil

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The present article reports the results of a systematic review on the potential benefits of the combined use of virtual reality (VR) and non-invasive brain stimulation (NIBS) as a novel approach for rehabilitation. VR and NIBS are two rehabilitation techniques that have been consistently explored by health professionals, and in recent years there is strong evidence of the therapeutic benefits of their combined use. In this work, we reviewed research articles that report the combined use of VR and two common NIBS techniques, namely transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS). Relevant queries to six major bibliographic databases were performed to retrieve original research articles that reported the use of the combination VR-NIBS for rehabilitation applications. A total of 16 articles were identified and reviewed. The reviewed studies have significant differences in the goals, materials, methods, and outcomes. These differences are likely caused by the lack of guidelines and best practices on how to combine VR and NIBS techniques. Five therapeutic applications were identified: stroke, neuropathic pain, cerebral palsy, phobia and post-traumatic stress disorder, and multiple sclerosis rehabilitation. The majority of the reviewed studies reported positive effects of the use of VR-NIBS. However, further research is still needed to validate existing results on larger sample sizes and across different clinical conditions. For these reasons, in this review recommendations for future studies exploring the combined use of VR and NIBS are presented to facilitate the comparison among works.

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Section: Resultsmentioning

confidence: 99%

Virtual reality and non-invasive brain stimulation for rehabilitation applications: a systematic review

Cassani

Novak

Falk

et al. 2020

J NeuroEngineering Rehabil

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“…The contained exposure that VR provides has led to controlled studies where the effects of cycloserine and alprazolam have been tested for the treatment of PTSD [ 32 , 33 , 40 ]. Similarly, VR environments have been used for Theta burst stimulation [ 41 ] for those with spider phobia. The literature review revealed that VR exposure showed positive results on levels of anxiety and, generally, was at least as effective as in vivo exposure, although in some cases, the latter was slightly more effective [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Head-Mounted Virtual Reality and Mental Health: Critical Review of Current Research

Jerdan¹,

Grindle²,

Woerden³

et al. 2018

JMIR Serious Games

143

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BackgroundeHealth interventions are becoming increasingly used in public health, with virtual reality (VR) being one of the most exciting recent developments. VR consists of a three-dimensional, computer-generated environment viewed through a head-mounted display. This medium has provided new possibilities to adapt problematic behaviors that affect mental health. VR is no longer unaffordable for individuals, and with mobile phone technology being able to track movements and project images through mobile head-mounted devices, VR is now a mobile tool that can be used at work, home, or on the move.ObjectiveIn line with recent advances in technology, in this review, we aimed to critically assess the current state of research surrounding mental health.MethodsWe compiled a table of 82 studies that made use of head-mounted devices in their interventions.ResultsOur review demonstrated that VR is effective in provoking realistic reactions to feared stimuli, particularly for anxiety; moreover, it proved that the immersive nature of VR is an ideal fit for the management of pain. However, the lack of studies surrounding depression and stress highlight the literature gaps that still exist.ConclusionsVirtual environments that promote positive stimuli combined with health knowledge could prove to be a valuable tool for public health and mental health. The current state of research highlights the importance of the nature and content of VR interventions for improved mental health. While future research should look to incorporate more mobile forms of VR, a more rigorous reporting of VR and computer hardware and software may help us understand the relationship (if any) between increased specifications and the efficacy of treatment.

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“…fNIRS has been implemented in the form of a wearable device capable of intuitively monitoring brain activity in real-life conditions28, it has shown promise over the past few decades to support rsFC studies in both healthy individuals27 and psychiatric patients1516 with depression29, attention deficit/hyperactive disorder30, and autism31, suggesting that alterations in rsFC strength has potential as a biomarker to examine different psychiatric disorder trajectories. Recently, the use of fNIRS to assess functional connectivity has been extended to psychiatric patients with arachnophobia32 and children with psychopathology risk33.…”

mentioning

confidence: 99%

Abnormal resting-state functional connectivity in the orbitofrontal cortex of heroin users and its relationship with anxiety: a pilot fNIRS study

Ieong¹,

Yuan²

2017

Sci Rep

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Drug addiction is widely linked to the orbitofrontal cortex (OFC), which is essential for regulating reward-related behaviors, emotional responses, and anxiety. Over the past two decades, neuroimaging has provided significant contributions revealing functional and structural alternations in the brains of drug addicts. However, the underlying neural mechanism in the OFC and its correlates with drug addiction and anxiety still require further elucidation. We first presented a pilot investigation to examine local networks in OFC regions through resting-state functional connectivity (rsFC) using functional near-infrared spectroscopy (fNIRS) from eight abstinent addicts in a heroin-dependent group (HD) and seven subjects in a control group (CG). We discovered that the HDs manifested enhanced interhemispheric correlation and rsFC. Moreover, small-worldness was explored in the brain networks. In addition to the altered rsFC in the OFC networks, our examinations demonstrated associations in the functional connectivity between the left inferior frontal gyrus and other OFC regions related to anxiety in the HDs. The study provides important preliminary evidence of the complex OFC networks in heroin addiction and suggests neural correlates of anxiety. It opens a window in application of fNIRS to predict psychiatric trajectories and may create new insights into neural adaptations resulting from chronic opiate intake.

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Functional co-activation within the prefrontal cortex supports the maintenance of behavioural performance in fear-relevant situations before an iTBS modulated virtual reality challenge in participants with spider phobia

Cited by 36 publications

References 55 publications

Virtual reality and non-invasive brain stimulation for rehabilitation applications: a systematic review

Virtual reality and non-invasive brain stimulation for rehabilitation applications: a systematic review

Head-Mounted Virtual Reality and Mental Health: Critical Review of Current Research

Abnormal resting-state functional connectivity in the orbitofrontal cortex of heroin users and its relationship with anxiety: a pilot fNIRS study

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