Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats

Ahmed, Abdelkareem A.; Fedail, Jaafar S.; Musa, Hassan Hussein; Kamboh, Asghar Ali; Sifaldin, Amal Z.; Musa, Taha Hussein

doi:10.1016/j.pathophys.2015.08.002

Cited by 54 publications

(33 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, in our experiment, catalase gene expression was not affected by diabetes or by crocin administration. Our result agrees with Ahmed et al [48], who showed that the diabetic state does not influence catalase gene expression. In another case, the expression of this gene was downregulated by the diabetic state [49], an effect not compensated for by the administration of antioxidants (e.g.…”

Section: Discussionsupporting

confidence: 94%

Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats

Margaritis

Angelopoulou

Lavrentiadou

et al. 2020

J of Biol Res-Thessaloniki

View full text Add to dashboard Cite

Background: Diabetes is regarded as an epidemiological threat for the twenty-first century. Phytochemicals with known pharmaceutical properties have gained interest in the field of alleviating secondary complications of diseases. Such a substance is crocin, a basic constituent of saffron (Crocus sativus). The present study aimed at examining the beneficial effects of per os crocin administration on the antioxidant status, blood biochemical profile, hepatic gene expression and plasminogen activator inhibitor-1 activity (PAI-1) in the liver, kidney and plasma (an important marker of pre-diabetic status and major factor of thrombosis in diabetes) of healthy rats, as well as of rats with nicotinamidestreptozotocin-induced diabetes. Results: Diabetes disrupted the oxidation-antioxidation balance, while crocin improved the antioxidant state in the liver by significantly affecting SOD1 gene expression and/or by restoring SOD and total antioxidant capacity (TAC) levels. In the kidney, crocin improved hydrogen peroxide decomposing activity and TAC. In blood, hepatic transaminases ALT and AST decreased significantly, while there was a trend of decrease regarding blood urea nitrogen (BUN) levels. The expression of PAI-1 gene was affected in the liver by the dose of 50 mg kg −1. Conclusions: Crocin treatment contributed in restoring some parameters after diabetes induction, primarily by affecting significantly hepatic transaminases ALT and AST, SOD1 and PAI-1 gene expression and nephric H 2 O 2 decomposing activity. In conclusion, crocin did contribute to the alleviation of some complications of diabetes.

show abstract

Section: Discussionsupporting

confidence: 94%

Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats

Margaritis

Angelopoulou

Lavrentiadou

et al. 2020

J of Biol Res-Thessaloniki

View full text Add to dashboard Cite

show abstract

“…Since the first report about the usefulness of GA in patients with CKD [22], several experimental and clinical publications have confirmed the salutary actions of GA in CKD [23-26]. GA has also been reported to be useful in mice with diabetic nephropathy [26] and in alloxan – induced diabetes in rats [27]. …”

Section: Introductionmentioning

confidence: 99%

Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats with Adenine-Induced Chronic Kidney Disease

Za’abi

Al-Salam

Suleimani

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: The effect of treatment with gum acacia (GA), a prebiotic shown previously to ameliorate chronic kidney disease (CKD), in diabetic and non – diabetic rats with adenine – induced CKD has been investigated using several conventional and novel physiological, biochemical, and histopathological parameters. Methods: Diabetes mellitus was induced in rats by a single injection of streptozotocin (STZ). Diabetic and non – diabetic rats were randomly divided into several groups, and given either normal food or food mixed with adenine (0.25% w/w, for five weeks) to induce CKD. Some of these groups were also concomitantly treated orally with GA in the drinking water (15% w/w). Results: Rats fed adenine alone exhibited physiological (decreased body weight, increased food and water intake and urine output), biochemical (increase in urinary albumin/creatinine ratio, plasma urea and, creatinine, indoxyl sulfate and phosphorus), inflammatory biomarkers (increased in neutrophil gelatinase-associated lipocalin, transforming growth factor beta -1, tumor necrosis factor alpha, adiponectin, cystatin C and interleukin-1β), oxidative biomarkers (8-isoprostane, 8 -hydroxy -2-deoxy guanosine), nitrosative stress biomarkers (nitrite and nitrate) and histopathological (increase in tubular necrosis and fibrosis) signs of CKD. STZ - induced diabetes alone worsened most of the renal function tests measured. Administration of adenine in STZ – diabetic rats further worsened the renal damage induced by adenine alone. GA significantly ameliorated the renal actions of adenine and STZ, given either singly or in combination, especially with regards to the histopathological damage. Conclusion: GA is a useful dietary agent in attenuating the progression of CKD in rats with streptozotocin-induced diabetes.

show abstract

“…Also, it might be attributed to the antioxidant properties of AG in many tissues like renal tissue [16], RBCs in sickle cell anemia (SCA) disease [19] and hepatic tissue as mentioned by Ahmed et al, [45] who stated that AG significantly decreased the level of hepatic enzymes, lipid peroxidation, antioxidant enzymes as well as the expression of oxidative stress genes. Activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), which may contribute to the alleviation of Schistosoma mansoni infection consequences similar to what has been reported in many other antioxidants like gold nanoparticles Ceratonia siliqua pod extract [46], limonin [47].…”

Section: Discussionmentioning

confidence: 99%

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

Selem

Rashed

Younis

et al. 2018

Preprint

View full text Add to dashboard Cite

Abstract. CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018; 26Schistosomiasis is one of the most socioeconomically exhausting parasitic 27 infection in tropical and subtropical areas. Praziquantel (PZQ), the only common 28 schistosocidal drug in use, is not efficient enough for treatment of immature infection. 29Arabic gum (AG) is a complex polysaccharide acts as anti-oxidant which modulates the Author summary 46Schistosomiasis is a major public health threat in many parts of the world, it 47 affects more than 240 million people in more than 70 countries and almost 800 million 48 people are at risk of acquiring this disease. Serious consequences and disabilities might . CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018;

show abstract

Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats

Cited by 54 publications

References 46 publications

Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats

Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats

Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats with Adenine-Induced Chronic Kidney Disease

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

Contact Info

Product

Resources

About