Gut Microbiota as a Therapeutic Target for Metabolic Disorders

Abstract

A growing body of evidence highlights the role of gut microbiota in the development of dysbiosis, which in turn influences host metabolism and disease phenotypes. Further studies are required to elucidate the precise mechanisms by which gut microbiota-derived mediators induce metabolic disorders and modulating interventions exert their beneficial effects in humans. The gut microbiota represents a novel potential therapeutic target for a range of metabolic disorders.

Alteration of gut microbiota by a Westernized lifestyle and its correlation with insulin resistance in non‐diabetic Japanese men

“…Recently, gut microbiota has been regarded as an essential organ, playing critical roles in controlling host metabolic homeostasis and organ physiology. In addition, gut microbiota alterations have been suggested to contribute to the pathogenesis of insulin resistance 7,8 . Gut microbiota vary with race, diet and lifestyle [9][10][11] .…”

The role of the gut microbiota in the regulation of incretin effects

“…На даний час мікробіоту визнано справжнім функціональним «органом» через її величезний вплив на здоров'я людини. Переважна більшість мікроорганізмів перебуває в кишковому тракті, де вони беруть активну участь у травленні, харчуванні, імунній регуляції та обміні речовин [12][13][14]. Склад та активність мікробіоти кишечнику можуть змінюватися з часом і залежать від різних чинників, включаючи спадковість, стать, вік, особливості харчування, стан здоров'я та застосування лікарських засобів і зокрема антибіотиків [15].…”

Predicting and preventing intestinal dysbiosis on the basis of pharmacological gut microbiota metabolism

“…The possible relationship(s) between intestinal dysbiosis and various degenerative intestinal‐based diseases, e.g. diabetes and obesity, is an ongoing focus of intense investigation . As a consequence of the results of such research, the focus is now on therapeutic strategies for such diseases based on modification of the gut microbiota .…”

“…Kang and co‐workers also reported different strategies involving fecal gut microbiota transplantation to treat obesity. Other studies correlated other degenerative diseases to gut microbiota activities and suggested therapeutic strategies to alleviate those disease states …”