Impact of Polyphenols and Polyphenol-Rich Dietary Sources on Gut Microbiota Composition

Etxeberría, Usune; Fernández‐Quintela, Alfredo; Milagro, Fermı́n I.; Aguirre, Leixuri; Martínez, Julian; Portillo, Marı́a P.

doi:10.1021/jf402506c

Cited by 308 publications

(232 citation statements)

References 72 publications

Supporting

Mentioning

225

Contrasting

Order By: Relevance

“…[93] In addition to traditional foods, pure polyphenols and polyphenol-rich foods (such as cocoa, tea, wine, soy products, and fruits) may significantly affect the composition of the gut microbiota. [94] Based on these results, the enhancement of the number of bifidobacteria and lactobacilli is currently regarded as a marker of intestinal health and as a possible screening marker for the identification of prebiotics.…”

Section: Prebioticsmentioning

confidence: 99%

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Lin

Chang²,

et al. 2014

Biomed J

100

View full text Add to dashboard Cite

Section: Prebioticsmentioning

confidence: 99%

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Lin

Chang²,

et al. 2014

Biomed J

100

View full text Add to dashboard Cite

“…Although the metabolism of these bioactive compounds has been well reported [34][35][36], few studies have described its bioconversion by gut bacteria [37]. Nevertheless, in view of the direct contact and the dual interaction existing between these natural bioactive compounds and the colonic gut microbial ecosystem [38], possible composition modifications in intestinal bacteria might be expected as a result of the consumption of these compounds, which might ultimately contribute to functional modifications in the host.…”

Section: Introductionmentioning

confidence: 99%

Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

Etxeberría

Arias

Boqué

et al. 2015

The Journal of Nutritional Biochemistry

377

251

View full text Add to dashboard Cite

Diet-induced obesity is associated to an imbalance in the normal gut microbiota composition.Resveratrol and quercetin, widely known for their health beneficial properties, have low bioavailability and, when reach the colon, they are targets of the gut microbial ecosystem. Hence, the use of these molecules in obesity might be considered as a potential strategy to modulate intestinal bacterial composition. The purpose of this study was to determine whether trans-resveratrol and quercetin administration could counteract gut microbiota dysbiosis produced by high-fat sucrose diet (HFS) and in turn, improve gut health. Wistar rats were randomized into four groups fed a HFS diet supplemented or not with trans-resveratrol (15 mg/kg BW/day), quercetin (30 mg/kg BW/day) or a combination of both polyphenols at those doses. Administration of both polyphenols together prevented body-weight gain and reduced serum insulin levels. Moreover, individual supplementation of trans-resveratrol and quercetin effectively reduced serum insulin levels and insulin resistance.Quercetin supplementation generated a great impact on gut microbiota composition at different taxonomic levels, attenuating Firmicutes/Bacteroidetes ratio and inhibiting the growth of bacterial species previously associated to diet-induced obesity (Erysipelotrichaceae, Bacillus, Eubacterium 1 cylindroides). Overall, the administration of quercetin was found to be effective in lessening HFS dietinduced gut microbiota dysbiosis. In contrast, trans-resveratrol supplementation alone or in combination with quercetin, scarcely modified the profile of gut bacteria, but acted at intestinal level altering the mRNA expression of tight-junction proteins (TJPs) and inflammation associated genes.

show abstract

“…There is a consensus of opinion from review articles that certain doses of selected polyphenols influence microbial populations in the gut; certain bacterial groups can be expanded, and others can be inhibited (8)(9)(10). Furthermore, the intake of polyphenols and their derived products have significant effects on gut microbiota composition and probably their functional effects in mammalian tissues.…”

mentioning

confidence: 99%

Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Unno

Sakuma

Mitsuhashi

2014

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Summary Alterations in gut microbiota composition offer insights that may be relevant for several chronic conditions, including obesity. This study aimed to evaluate the effect of (2)-epigallocatechin gallate (EGCG) on the modulation of gut microbiota and biomarkers of colonic fermentation end-products in rats. Rats were fed an assigned diet of either a control diet, a 0.3% (w/w) EGCG diet, or a 0.6% (w/w) EGCG diet for 4 wk. Compared to the control group, the addition of 0.6% EGCG to the diet brought about a significant increase in the starch and protein contents in the feces collected in the fourth week of feeding, but the relative weights of abdominal adipose tissues of rats were inversely suppressed. Hostspecific bacterial community composition, as determined by terminal restriction fragment length polymorphism (T-RFLP) patterns for fecal 16S ribosomal RNA, showed a significant response in the reduced occupation of Clostridium spp. and an increased trend of Bacteroides by dietary supplementation with EGCG. The 0.6% EGCG diet also influenced the status of Bifidobacterium and Prevotella to a lesser extent. Interestingly, the cecum of rats fed the 0.6% EGCG diet contained lower levels of acetic and butyric acids, whereas EGCG had little influence on the cecal level of propionic acid. EGCG also reduced the cecal p-cresol concentration in a dose-dependent fashion. In conclusion, dietary EGCG affects the growth of certain species of gut microbiota in rats and is associated with the cecal pattern of short chain fatty acids which could be responsible for regulating energy metabolism in the body.

show abstract

Impact of Polyphenols and Polyphenol-Rich Dietary Sources on Gut Microbiota Composition

Cited by 308 publications

References 72 publications

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Impact of the gut microbiota, prebiotics, and probiotics on human health and disease

Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats

Effect of Dietary Supplementation of (^|^minus;)-Epigallocatechin Gallate on Gut Microbiota and Biomarkers of Colonic Fermentation in Rats

Contact Info

Product

Resources

About